IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area
Fu, Hongwei1; Li, Lingjun1; Zhu, Yonghong1; Wang, Ling1; Geng, Jiabao1; Chang, Yibin1; Xue, Cheng2; Du, Gang3; Li, Yaning3; Zhuang, Hui1
刊名AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
2010-05-01
DOI10.4269/ajtmh.2010.09.0689
82期:5页:961-966
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health ; Tropical Medicine
研究领域[WOS]Public, Environmental & Occupational Health ; Tropical Medicine
关键词[WOS]GENOME NUCLEOTIDE-SEQUENCE ; EASTERN CHINA ; GENETIC DIVERSITY ; DOMESTIC-ANIMALS ; WILD RATS ; HEV ; IDENTIFICATION ; PREVALENCE ; ANTIBODIES ; GENOTYPE
英文摘要

Hepatitis E is a worldwide public health problem, especially in areas with poor Sanitation. This study examines the potential hepatitis E virus (HEV) animal reservoirs and the current status of HEV infection among animals and humans in an endemic area of Xinjiang, China. One thousand five hundred twenty-one serum samples from 12 different animal species and 296 sera from humans were detected for anti-HEV with an in-house enzyme immunoassay, and partial HEV RNA was amplified with a reverse transcription nested polymerase chain reaction (RT-nPCR). All these distinct animal species, except jerboa and hoptoad, were positive for anti-HEV. However, HEN RNA was only amplified from pigs and a sporadic hepatitis E case in humans. The human HEV strain (CHN-XJ-HE29) shared 100% nucleotide identity with the swine HEV strain (CHN-XJ-SW50). both of which were collected from the same district: this indicates the possibility of HEV transmission from swine to humans in an endemic area.

语种英语
WOS记录号WOS:000277406500034
项目编号30570063 ; 2006A A02Z453
资助机构National Natural Science Foundation of China ; 863 National High Technology Research and Development Program of China
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62192
专题北京大学基础医学院_病原生物学系
作者单位1.Peoples Hosp Qiemo Cty, Clin Lab, Qiemo, Xinjiang Uighur, Peoples R China
2.Cent Hosp Kelamayi, Clin Lab, Kelamayi, Xinjiang Uigher, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
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GB/T 7714
Fu, Hongwei,Li, Lingjun,Zhu, Yonghong,et al. Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,2010,82(5):961-966.
APA Fu, Hongwei.,Li, Lingjun.,Zhu, Yonghong.,Wang, Ling.,Geng, Jiabao.,...&Zhuang, Hui.(2010).Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area.AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,82(5),961-966.
MLA Fu, Hongwei,et al."Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area".AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 82.5(2010):961-966.
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