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学科主题: 基础医学
题名:
Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area
作者: Fu, Hongwei1; Li, Lingjun1; Zhu, Yonghong1; Wang, Ling1; Geng, Jiabao1; Chang, Yibin1; Xue, Cheng2; Du, Gang3; Li, Yaning3; Zhuang, Hui1
刊名: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
发表日期: 2010-05-01
DOI: 10.4269/ajtmh.2010.09.0689
卷: 82, 期:5, 页:961-966
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health ; Tropical Medicine
研究领域[WOS]: Public, Environmental & Occupational Health ; Tropical Medicine
关键词[WOS]: GENOME NUCLEOTIDE-SEQUENCE ; EASTERN CHINA ; GENETIC DIVERSITY ; DOMESTIC-ANIMALS ; WILD RATS ; HEV ; IDENTIFICATION ; PREVALENCE ; ANTIBODIES ; GENOTYPE
英文摘要:

Hepatitis E is a worldwide public health problem, especially in areas with poor Sanitation. This study examines the potential hepatitis E virus (HEV) animal reservoirs and the current status of HEV infection among animals and humans in an endemic area of Xinjiang, China. One thousand five hundred twenty-one serum samples from 12 different animal species and 296 sera from humans were detected for anti-HEV with an in-house enzyme immunoassay, and partial HEV RNA was amplified with a reverse transcription nested polymerase chain reaction (RT-nPCR). All these distinct animal species, except jerboa and hoptoad, were positive for anti-HEV. However, HEN RNA was only amplified from pigs and a sporadic hepatitis E case in humans. The human HEV strain (CHN-XJ-HE29) shared 100% nucleotide identity with the swine HEV strain (CHN-XJ-SW50). both of which were collected from the same district: this indicates the possibility of HEV transmission from swine to humans in an endemic area.

语种: 英语
所属项目编号: 30570063 ; 2006A A02Z453
项目资助者: National Natural Science Foundation of China ; 863 National High Technology Research and Development Program of China
WOS记录号: WOS:000277406500034
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62192
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peoples Hosp Qiemo Cty, Clin Lab, Qiemo, Xinjiang Uighur, Peoples R China
2.Cent Hosp Kelamayi, Clin Lab, Kelamayi, Xinjiang Uigher, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China

Recommended Citation:
Fu, Hongwei,Li, Lingjun,Zhu, Yonghong,et al. Hepatitis E Virus Infection among Animals and Humans in Xinjiang, China: Possibility of Swine to Human Transmission of Sporadic Hepatitis E in an Endemic Area[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,2010,82(5):961-966.
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