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学科主题基础医学
Distribution of beacon immunoreactivity in the rat brain
Wang, F; Tian, DR; Tian, N; Chen, H; Shi, YS; Chang, JK; Yang, J; Yuan, L; Han, JS
关键词beacon corticotrophin-releasing hormone rat brain feeding behavior
刊名PEPTIDES
2006
DOI10.1016/j.peptides.2005.07.011
27期:1页:165-171
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ORGAN/REISSNERS FIBER COMPLEX ; SUBCOMMISSURAL ORGAN ; POTENT ACTIVITY ; SCO-SPONDIN ; GENE ; HYPOTHALAMUS ; GLYCOPROTEIN ; VASOPRESSIN ; PITUITARY ; OXYTOCIN
英文摘要

Beacon is a novel peptide isolated from the hypothalamus of Israeli sand rat. In the present study, we determined the distribution of beacon in the rat brain using immunohistochemical approach with a polyclonal antiserum directed against the synthetic C-terminal peptide fragment (47-73). The hypothalamus represented the major site of beacon - immunoreactive (IR) cell bodies that were concentrated in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON). Additional immunostained cells were found in the septum, bed nucleus of the stria terminalis, subfornical organ and subcommissural organ. Beacon-IR fibers were seen with high density in the internal layer of the median eminence and low to moderate density in the external layer. Significant beacon-IR fibers were also seen in the nucleus of the solitary tract and lateral reticular formation. The beacon neurons found in the PVN were further characterized by double label immunohistochemistry. Several beacon-IR neurons that resided in the medial PVN were shown to coexpress corticotrophin-releasing hormone (CRH) and most labeled beacon fibers in the external layer of median eminence coexist with CRH. The topographical distribution of beacon-IR in the brain suggests multiple biological activities for beacon in addition to its proposed roles in modulating feeding behaviors and pituitary hormone release. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000234930300024
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62194
专题基础医学院_神经生物学系
作者单位1.Peking Univ, Minist Educ & Minist Hlth, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ & Minist Hlth, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China
3.Phoenix Pharmaceut Inc, Belmont, CA 94002 USA
4.Tianjin Med Univ, Dept Anat, Tianjin 300070, Peoples R China
5.Peking Univ, Med & Hlth Anal Ctr, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, F,Tian, DR,Tian, N,et al. Distribution of beacon immunoreactivity in the rat brain[J]. PEPTIDES,2006,27(1):165-171.
APA Wang, F.,Tian, DR.,Tian, N.,Chen, H.,Shi, YS.,...&Han, JS.(2006).Distribution of beacon immunoreactivity in the rat brain.PEPTIDES,27(1),165-171.
MLA Wang, F,et al."Distribution of beacon immunoreactivity in the rat brain".PEPTIDES 27.1(2006):165-171.
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