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学科主题: 基础医学
题名:
Distribution of beacon immunoreactivity in the rat brain
作者: Wang, F; Tian, DR; Tian, N; Chen, H; Shi, YS; Chang, JK; Yang, J; Yuan, L; Han, JS
关键词: beacon ; corticotrophin-releasing hormone ; rat brain ; feeding behavior
刊名: PEPTIDES
发表日期: 2006
DOI: 10.1016/j.peptides.2005.07.011
卷: 27, 期:1, 页:165-171
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: ORGAN/REISSNERS FIBER COMPLEX ; SUBCOMMISSURAL ORGAN ; POTENT ACTIVITY ; SCO-SPONDIN ; GENE ; HYPOTHALAMUS ; GLYCOPROTEIN ; VASOPRESSIN ; PITUITARY ; OXYTOCIN
英文摘要:

Beacon is a novel peptide isolated from the hypothalamus of Israeli sand rat. In the present study, we determined the distribution of beacon in the rat brain using immunohistochemical approach with a polyclonal antiserum directed against the synthetic C-terminal peptide fragment (47-73). The hypothalamus represented the major site of beacon - immunoreactive (IR) cell bodies that were concentrated in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON). Additional immunostained cells were found in the septum, bed nucleus of the stria terminalis, subfornical organ and subcommissural organ. Beacon-IR fibers were seen with high density in the internal layer of the median eminence and low to moderate density in the external layer. Significant beacon-IR fibers were also seen in the nucleus of the solitary tract and lateral reticular formation. The beacon neurons found in the PVN were further characterized by double label immunohistochemistry. Several beacon-IR neurons that resided in the medial PVN were shown to coexpress corticotrophin-releasing hormone (CRH) and most labeled beacon fibers in the external layer of median eminence coexist with CRH. The topographical distribution of beacon-IR in the brain suggests multiple biological activities for beacon in addition to its proposed roles in modulating feeding behaviors and pituitary hormone release. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000234930300024
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62194
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Minist Educ & Minist Hlth, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ & Minist Hlth, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China
3.Phoenix Pharmaceut Inc, Belmont, CA 94002 USA
4.Tianjin Med Univ, Dept Anat, Tianjin 300070, Peoples R China
5.Peking Univ, Med & Hlth Anal Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Wang, F,Tian, DR,Tian, N,et al. Distribution of beacon immunoreactivity in the rat brain[J]. PEPTIDES,2006,27(1):165-171.
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