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学科主题: 药学
题名:
Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes
作者: Dai, Wenbing1,2; Jin, Wu1; Zhang, Junlin1; Wang, Xueqing1; Wang, Jiancheng1; Zhang, Xuan1; Wan, You2; Zhang, Qiang1
关键词: combretastatin A-4 ; doxorubicin ; octreotide ; programmed release ; spatiotemporally controlled co-delivery ; targeted delivery
刊名: PHARMACEUTICAL RESEARCH
发表日期: 2012-10-01
DOI: 10.1007/s11095-012-0797-2
卷: 29, 期:10, 页:2902-2911
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CELL LUNG-CANCER ; COMBRETASTATIN A4 PHOSPHATE ; THYROID-CARCINOMA ; TARGETED DELIVERY ; HIGH-AFFINITY ; TUMOR-GROWTH ; SOMATOSTATIN ; DOXORUBICIN ; CHEMOTHERAPY ; THERAPY
英文摘要:

Both combretastatin A-4 (CA-4) and doxorubicin (DOX) was loaded in different form in a targeted nanomedicine in order to achieve the active delivery of these two drugs followed by sequentially suppressing tumor vasculature and tumor cells.

Octreotide-modified stealth liposomes loaded with CA-4 and DOX (Oct-L[CD]) were prepared and characterized. Then in vitro release, cellular uptake, in vitro antitumor effect, pharmacokinetics, in vivo sequential killing effect, in vivo antitumor efficacy against somatostatin receptor (SSTR) positive cells, as well as the action mechanism of such system, were studied.

A rapid release of CA-4 followed by a slow release of DOX was observed in vitro. The active targeted liposomes Oct-L[CD] showed a specific cellular uptake through ligand-receptor interaction and a higher antitumor effect in vitro against SSTR-positive cell line. The in vivo sequential killing effect of such system was found as evidenced by the fast inhibition of blood vessels and slow apoptosis-inducing of tumor cells. Oct-L[CD] also exhibited the strongest antitumor effect in MCF-7 subcutaneous xenograft models.

Oct-modified co-delivery system may have great potential as an effective carrier for cancer therapy.

语种: 英语
所属项目编号: 81130059 ; 2009CB930300
项目资助者: National Nature Science Foundation ; National Basic Research Program of China
WOS记录号: WOS:000308701500020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62195
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Dept Neurobiol, Beijing 100191, Peoples R China

Recommended Citation:
Dai, Wenbing,Jin, Wu,Zhang, Junlin,et al. Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes[J]. PHARMACEUTICAL RESEARCH,2012,29(10):2902-2911.
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