|Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes|
|Dai, Wenbing1,2; Jin, Wu1; Zhang, Junlin1; Wang, Xueqing1; Wang, Jiancheng1; Zhang, Xuan1; Wan, You2; Zhang, Qiang1|
|关键词||combretastatin A-4 doxorubicin octreotide programmed release spatiotemporally controlled co-delivery targeted delivery|
|WOS标题词||Science & Technology|
|类目[WOS]||Chemistry, Multidisciplinary ; Pharmacology & Pharmacy|
|研究领域[WOS]||Chemistry ; Pharmacology & Pharmacy|
|关键词[WOS]||CELL LUNG-CANCER ; COMBRETASTATIN A4 PHOSPHATE ; THYROID-CARCINOMA ; TARGETED DELIVERY ; HIGH-AFFINITY ; TUMOR-GROWTH ; SOMATOSTATIN ; DOXORUBICIN ; CHEMOTHERAPY ; THERAPY|
Both combretastatin A-4 (CA-4) and doxorubicin (DOX) was loaded in different form in a targeted nanomedicine in order to achieve the active delivery of these two drugs followed by sequentially suppressing tumor vasculature and tumor cells.
Octreotide-modified stealth liposomes loaded with CA-4 and DOX (Oct-L[CD]) were prepared and characterized. Then in vitro release, cellular uptake, in vitro antitumor effect, pharmacokinetics, in vivo sequential killing effect, in vivo antitumor efficacy against somatostatin receptor (SSTR) positive cells, as well as the action mechanism of such system, were studied.
A rapid release of CA-4 followed by a slow release of DOX was observed in vitro. The active targeted liposomes Oct-L[CD] showed a specific cellular uptake through ligand-receptor interaction and a higher antitumor effect in vitro against SSTR-positive cell line. The in vivo sequential killing effect of such system was found as evidenced by the fast inhibition of blood vessels and slow apoptosis-inducing of tumor cells. Oct-L[CD] also exhibited the strongest antitumor effect in MCF-7 subcutaneous xenograft models.
Oct-modified co-delivery system may have great potential as an effective carrier for cancer therapy.
|项目编号||81130059 ; 2009CB930300|
|资助机构||National Nature Science Foundation ; National Basic Research Program of China|
|作者单位||1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China|
2.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Dept Neurobiol, Beijing 100191, Peoples R China
|Dai, Wenbing,Jin, Wu,Zhang, Junlin,et al. Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes[J]. PHARMACEUTICAL RESEARCH,2012,29(10):2902-2911.|
|APA||Dai, Wenbing.,Jin, Wu.,Zhang, Junlin.,Wang, Xueqing.,Wang, Jiancheng.,...&Zhang, Qiang.(2012).Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes.PHARMACEUTICAL RESEARCH,29(10),2902-2911.|
|MLA||Dai, Wenbing,et al."Spatiotemporally Controlled Co-delivery of Anti-vasculature Agent and Cytotoxic Drug by Octreotide-Modified Stealth Liposomes".PHARMACEUTICAL RESEARCH 29.10(2012):2902-2911.|