IR@PKUHSC  > 北京大学第二临床医学院  > 肝病科
学科主题临床医学
Abnormal CD4+T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection
Kong, Fanyun1,2,3; Zhang, Wei1; Feng, Bo1; Zhang, Henghui1; Rao, Huiying1; Wang, Jianghua1; Cong, Xu1; Wei, Lai1
关键词Hepatitis C Type III asymptomatic cryoglobulinemia CD4+T helper cells Activated memory B cells
刊名VIROLOGY JOURNAL
2015-07-01
DOI10.1186/s12985-015-0324-2
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]CHRONIC HEPATITIS-C ; PERIPHERAL-BLOOD LYMPHOCYTES ; VIRUS-INFECTION ; SERUM-LEVELS ; AUTOIMMUNE-THYROIDITIS ; CIRCULATING CXCL11 ; INTERFERON-GAMMA ; HIGH VALUES ; CYTOKINES ; LIVER
英文摘要

Background: Mixed cryoglobulinemia (MC) in hepatitis C virus (HCV) infection is associated with abnormal immune responses mediated by T cells and B cells, while the relationships of different subsets of CD4 + T helper (Th) cells, B cells and associated cytokines with type III asymptomatic MC in HCV infection are poorly understood.

Methods: Fifty-four chronic hepatitis C (CHC) patients and 23 healthy controls (HCs) were enrolled in the study. Serum cryoglobulins were detected by cryoprecipitation. The types of cryoglobulin were determined by western blot. The phenotypes and frequencies of Th cell and B cell subsets were detected by flow cytometric analysis. The cytokines IFN-gamma, IL-4, IL-17, IL-21, IL-22, and TGF-beta were measured by enzyme-linked immunosorbent assay.

Results: Twenty-six CHC patients were detected with type III asymptomatic MC. The frequencies of Th2, Th17, follicular helper T (Tfh cells), Th22, and tissue-like B cells were significantly higher in CHC patients compared to HCs, while these cell subsets were not significantly different between CHC patients and HCV-related MC patients. The frequencies of Th1 and activated memory B cells increased in HCV-related MC patients compared to HCs, although the difference between the two cell subsets in CHC patients and HCs was not significant. The frequency of regulatory T cells (Treg cells) was higher in CHC patients than in HCV-related MC patients and HCs. Higher expressions of serum IFN-gamma, IL-17, IL-21, and IL-22 were observed in CHC patients than in HCs, but the differences were not significantly different in CHC patients and HCV-related MC patients. The frequency of Th1 cells was associated with activated memory B cells in HCV-related MC patients, and the frequency of Th1 cells and activated memory B cells was closely related to HCV RNA in HCV-related MC patients.

Conclusions: The increased frequencies of Th17 cells, Tfh cells, Th22 cells, Treg cells, cytokines IL-17, IL-21, IL-22, and tissue-like B cells, were related to HCV infection but not type III asymptomatic MC. Higher frequencies of Th1 cells and activated memory B cells were associated with type III asymptomatic MC in HCV infection.

语种英语
WOS记录号WOS:000357775200001
项目编号2012ZX10002003
资助机构National Science and Technology Major Project for Infectious Diseases Control
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62197
专题北京大学第二临床医学院_肝病科
北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Peoples Hosp, Beijing Key Lab Hepatitis & Immunotherapy Liver C, Inst Hepatol, Beijing 100044, Peoples R China
2.Xuzhou Med Coll, Dept Pathogen Biol, Xuzhou 221002, Jiangsu, Peoples R China
3.Xuzhou Med Coll, Lab Infect & Immunol, Xuzhou 221002, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Kong, Fanyun,Zhang, Wei,Feng, Bo,et al. Abnormal CD4+T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection[J]. VIROLOGY JOURNAL,2015,12.
APA Kong, Fanyun.,Zhang, Wei.,Feng, Bo.,Zhang, Henghui.,Rao, Huiying.,...&Wei, Lai.(2015).Abnormal CD4+T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection.VIROLOGY JOURNAL,12.
MLA Kong, Fanyun,et al."Abnormal CD4+T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection".VIROLOGY JOURNAL 12(2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Kong, Fanyun]的文章
[Zhang, Wei]的文章
[Feng, Bo]的文章
百度学术
百度学术中相似的文章
[Kong, Fanyun]的文章
[Zhang, Wei]的文章
[Feng, Bo]的文章
必应学术
必应学术中相似的文章
[Kong, Fanyun]的文章
[Zhang, Wei]的文章
[Feng, Bo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。