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Long-term efficacy and safety of pamidronate disodium in treatment of bone metastases in breast cancer
Di, Li-jun; Ren, Jun; Yan, Ying; Wan, Feng-ling; Song, Guo-gong; Yu, Jing
关键词Pamidronate disodium Skeletal related event Bone metastases Breast cancer
刊名CHINESE JOURNAL OF CANCER RESEARCH
2009-06-01
DOI10.1007/s11670-009-0109-5
21期:2页:109-114
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SKELETAL COMPLICATIONS ; AMERICAN SOCIETY ; ZOLEDRONIC ACID ; BISPHOSPHONATES ; MANAGEMENT ; WOMEN ; MALIGNANCY ; TRIALS
英文摘要

To evaluate the long-term efficacy and safety of pamidronate disodium in patients with bone lesions secondary to advanced breast carcinoma.

A retrospective chart review was conducted of 62 patients receiving intravenous pamidronate disodium for metastatic breast cancer. The proportion of patients experiencing at least one skeletal related event (SRE) after 12 months of therapy was determined.

The proportion of patients who had an SRE was 29.00% (18 individuals) and the median time to first event was greater than 350 days. Radiotherapy(11 individuals)and pathologic fracture(6 individuals)were the most frequent type of SRE, while cord compression(1 individuals) and hypercalcaemia(0 individuals) were rare. A total of 37 individuals had transient hypocalcaemia without any clinical symptom. No significant creatinine abnormalities were encountered. There were no clinically relevant changes of calcium, phosphate and creatinine before and after therapy.

Long-term treatment with pamidronate disodium significantly reduces and delays skeletal morbidity from osteolytic metastases. Prolonged therapy was well tolerated. This study suggests that the rate of clinically relevant SREs is substantially lower than the event rate observed in phase III clinical trials.

语种英语
WOS记录号WOS:000266946900005
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62198
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_乳腺肿瘤内科
北京大学临床肿瘤学院_移植与免疫治疗病区
作者单位Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst,Minist Educ, Beijing 100142, Peoples R China
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GB/T 7714
Di, Li-jun,Ren, Jun,Yan, Ying,et al. Long-term efficacy and safety of pamidronate disodium in treatment of bone metastases in breast cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(2):109-114.
APA Di, Li-jun,Ren, Jun,Yan, Ying,Wan, Feng-ling,Song, Guo-gong,&Yu, Jing.(2009).Long-term efficacy and safety of pamidronate disodium in treatment of bone metastases in breast cancer.CHINESE JOURNAL OF CANCER RESEARCH,21(2),109-114.
MLA Di, Li-jun,et al."Long-term efficacy and safety of pamidronate disodium in treatment of bone metastases in breast cancer".CHINESE JOURNAL OF CANCER RESEARCH 21.2(2009):109-114.
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