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学科主题: 临床医学
题名:
Long-term efficacy and safety of pamidronate disodium in treatment of bone metastases in breast cancer
作者: Di, Li-jun; Ren, Jun; Yan, Ying; Wan, Feng-ling; Song, Guo-gong; Yu, Jing
关键词: Pamidronate disodium ; Skeletal related event ; Bone metastases ; Breast cancer
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2009-06-01
DOI: 10.1007/s11670-009-0109-5
卷: 21, 期:2, 页:109-114
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SKELETAL COMPLICATIONS ; AMERICAN SOCIETY ; ZOLEDRONIC ACID ; BISPHOSPHONATES ; MANAGEMENT ; WOMEN ; MALIGNANCY ; TRIALS
英文摘要:

To evaluate the long-term efficacy and safety of pamidronate disodium in patients with bone lesions secondary to advanced breast carcinoma.

A retrospective chart review was conducted of 62 patients receiving intravenous pamidronate disodium for metastatic breast cancer. The proportion of patients experiencing at least one skeletal related event (SRE) after 12 months of therapy was determined.

The proportion of patients who had an SRE was 29.00% (18 individuals) and the median time to first event was greater than 350 days. Radiotherapy(11 individuals)and pathologic fracture(6 individuals)were the most frequent type of SRE, while cord compression(1 individuals) and hypercalcaemia(0 individuals) were rare. A total of 37 individuals had transient hypocalcaemia without any clinical symptom. No significant creatinine abnormalities were encountered. There were no clinically relevant changes of calcium, phosphate and creatinine before and after therapy.

Long-term treatment with pamidronate disodium significantly reduces and delays skeletal morbidity from osteolytic metastases. Prolonged therapy was well tolerated. This study suggests that the rate of clinically relevant SREs is substantially lower than the event rate observed in phase III clinical trials.

语种: 英语
WOS记录号: WOS:000266946900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62198
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Di, Li-jun,Ren, Jun,Yan, Ying,et al. Long-term efficacy and safety of pamidronate disodium in treatment of bone metastases in breast cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(2):109-114.
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