IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia
Qi, YF; Shi, YR; Bu, DF; Pang, YZ; Tang, CS
关键词adrenomedullin myocardiopathy aorta receptor activity modifying protein 2 (RAMP2)
刊名PEPTIDES
2003-03-01
DOI10.1016/S0196-9781(03)00063-9
24期:3页:463-468
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]COMPETITIVE PCR ; GENE-EXPRESSION ; PEPTIDE ; PROADRENOMEDULLIN
英文摘要

Adrenomedullin is a potent vasodilator peptide originally isolated from a pheochromocytoma. Recently, a novel adrenomedullin receptor has been identified as a complex of calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). To explore the pathophysiological roles of adrenomedullin and its receptor component RAMP2 in ischemic cardiovascular diseases, we studied the changes of adrenomedullin and RAMP2 mRNA in myocardium and aorta in rats with isoproterenol (ISO)-induced myocardial impairment. In ISO-treated rats, heart became enlarged markedly, the ratio of heart to body weight was increased by 54% (P < 0.01), and myocardial malondialdehyde content and plasma lactate dehydrogenase activity was elevated by 43% (P < 0.01) and 138% (P < 0.01), respectively. Inummoreactive adrenomedullin (ADM) in plasma, myocardium and aorta was augmented by 116.7% (P < 0.01), 50.8% (P < 0.01) and 12.5% (P > 0.05), respectively. ADM mRNA in myocardium and aorta was increased by 96.8% (P < 0.01) and 38.5% (P < 0.01), respectively. RAMP2 mRNA in myocardium and aorta was increased by 19.6% (P < 0.05) and 15.8% (P < 0.01), respectively. These results suggest that the increase of ADM level and the up-regulation of ADM and RAMP2 gene in myocardium and aorta may be significant in the pathogenesis of ischemic myocardiopathy. (C) 2003 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000183006100018
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62200
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Peking Univ, Cardiovasc Res Inst, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Qi, YF,Shi, YR,Bu, DF,et al. Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia[J]. PEPTIDES,2003,24(3):463-468.
APA Qi, YF,Shi, YR,Bu, DF,Pang, YZ,&Tang, CS.(2003).Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia.PEPTIDES,24(3),463-468.
MLA Qi, YF,et al."Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia".PEPTIDES 24.3(2003):463-468.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qi, YF]的文章
[Shi, YR]的文章
[Bu, DF]的文章
百度学术
百度学术中相似的文章
[Qi, YF]的文章
[Shi, YR]的文章
[Bu, DF]的文章
必应学术
必应学术中相似的文章
[Qi, YF]的文章
[Shi, YR]的文章
[Bu, DF]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。