北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia
作者: Qi, YF; Shi, YR; Bu, DF; Pang, YZ; Tang, CS
关键词: adrenomedullin ; myocardiopathy ; aorta ; receptor activity modifying protein 2 (RAMP2)
刊名: PEPTIDES
发表日期: 2003-03-01
DOI: 10.1016/S0196-9781(03)00063-9
卷: 24, 期:3, 页:463-468
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: COMPETITIVE PCR ; GENE-EXPRESSION ; PEPTIDE ; PROADRENOMEDULLIN
英文摘要:

Adrenomedullin is a potent vasodilator peptide originally isolated from a pheochromocytoma. Recently, a novel adrenomedullin receptor has been identified as a complex of calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). To explore the pathophysiological roles of adrenomedullin and its receptor component RAMP2 in ischemic cardiovascular diseases, we studied the changes of adrenomedullin and RAMP2 mRNA in myocardium and aorta in rats with isoproterenol (ISO)-induced myocardial impairment. In ISO-treated rats, heart became enlarged markedly, the ratio of heart to body weight was increased by 54% (P < 0.01), and myocardial malondialdehyde content and plasma lactate dehydrogenase activity was elevated by 43% (P < 0.01) and 138% (P < 0.01), respectively. Inummoreactive adrenomedullin (ADM) in plasma, myocardium and aorta was augmented by 116.7% (P < 0.01), 50.8% (P < 0.01) and 12.5% (P > 0.05), respectively. ADM mRNA in myocardium and aorta was increased by 96.8% (P < 0.01) and 38.5% (P < 0.01), respectively. RAMP2 mRNA in myocardium and aorta was increased by 19.6% (P < 0.05) and 15.8% (P < 0.01), respectively. These results suggest that the increase of ADM level and the up-regulation of ADM and RAMP2 gene in myocardium and aorta may be significant in the pathogenesis of ischemic myocardiopathy. (C) 2003 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000183006100018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62200
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Peking Univ, Cardiovasc Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Qi, YF,Shi, YR,Bu, DF,et al. Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia[J]. PEPTIDES,2003,24(3):463-468.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qi, YF]'s Articles
[Shi, YR]'s Articles
[Bu, DF]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qi, YF]‘s Articles
[Shi, YR]‘s Articles
[Bu, DF]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace