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学科主题: 基础医学
题名:
Urea transporter physiology studied in knockout mice
作者: Li, Xuechen1,2; Chen, Guangping3; Yang, Baoxue1,2
关键词: knock out mouse ; urea transport ; urea transporter inhibitor ; urinary concentrating mechanism
刊名: FRONTIERS IN PHYSIOLOGY
发表日期: 2012
DOI: 10.3389/fphys.2012.00217
卷: 3
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Physiology
研究领域[WOS]: Physiology
英文摘要:

In mammals, there are two types of urea transporters; urea transporter (UT)-A and UT-B. The UT-A transporters are mainly expressed in kidney epithelial cells while UT-B demonstrates a broader distribution in kidney, heart, brain, testis, urinary tract, and other tissues. Over the past few years, multiple urea transporter knockout mouse models have been generated enabling us to explore the physiological roles of the different urea transporters. In the kidney, deletion of UT-A1/UT-A3 results in polyuria and a severe urine concentrating defect, indicating that intrarenal recycling of urea plays a crucial role in the overall capacity to concentrate urine. Since UT-B has a wide tissue distribution, multiple phenotypic abnormalities have been found in UT-B null mice, such as defective urine concentration, exacerbated heart blockage with aging, depression-like behavior, and earlier male sexual maturation. This review summarizes the new insights of urea transporter functions in different organs, gleaned from studies of urea transporter knockout mice, and explores some of the potential pharmacological prospects of urea transporters.

语种: 英语
所属项目编号: 30870921 ; 81170632 ; 2009ZX09301-010-30 ; 20100001110047 ; R01-DK087838
项目资助者: Chinese National Natural Science Foundation ; Drug Discovery Program ; Doctoral Program of Higher Education ; NIH
WOS记录号: WOS:000209173000214
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62202
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Emory Univ, Sch Med, Div Renal, Atlanta, GA 30322 USA
3.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Li, Xuechen,Chen, Guangping,Yang, Baoxue. Urea transporter physiology studied in knockout mice[J]. FRONTIERS IN PHYSIOLOGY,2012,3.
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