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学科主题: 临床医学
题名:
Natural History of Small Renal Masses
作者: Zhang, Lei; Li, Xue-Song; Zhou, Li-Qun
关键词: Active Surveillance ; Growth Kinetics ; Natural History ; Small Renal Masses
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-05-05
DOI: 10.4103/0366-6999.156139
卷: 128, 期:9, 页:1232-1237
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; TERM-FOLLOW-UP ; ACTIVE SURVEILLANCE ; CELL CARCINOMA ; GROWTH-RATE ; PARTIAL NEPHRECTOMY ; RADICAL NEPHRECTOMY ; CORE BIOPSY ; TUMOR SIZE ; CONSERVATIVE MANAGEMENT
英文摘要:

Objective: To review the natural history and growth kinetics of small renal masses (SRMs).

Data Sources: The literature concerning natural history and growth kinetics of SRMs was collected from PubMed published from 1990 to 2014.

Study Selection: We included all the relevant articles on the active surveillance (AS) or delayed treatment for SRMs in English, with no limitation of study design.

Results: SRMs under AS have a slow growth potential in general. The mean linear growth rate is 0.33 cm/year, the mean volumetric growth rate is 9.48 cm (3) /year. The rate of metastasis during AS is below 2%. Some factors are associated with the growth rate of SRMs, including tumor grade, histological subtype, initial tumor size, age, radiographic characteristics, and molecular markers. No definite predictor of growth rate of SRMs is defined at present. SRMs with high tumor grade and the subtype of clear cell renal cell carcinoma may have aggressive growth potential.

Conclusions: AS is a reasonable choice for elderly patients with SRMs, who are at high risk from surgery. Progression during observation is the biggest concern while performing AS. There is no definite predictor of progression for SRMs under AS. Percutaneous renal biopsy providing immunohistological and genic biomarkers may improve the understanding of natural history of SRMs.

语种: 英语
WOS记录号: WOS:000354186800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62203
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Lei,Li, Xue-Song,Zhou, Li-Qun. Natural History of Small Renal Masses[J]. CHINESE MEDICAL JOURNAL,2015,128(9):1232-1237.
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