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学科主题临床医学
Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis
Ma, Hui1; Wei, Lai1; Guo, Fang1; Zhu, Sainan2; Sun, Yan1; Wang, Hao1
关键词Chinese patients HBeAg negative liver cirrhosis survival
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2008-08-01
DOI10.1111/j.1440-1746.2008.05499.x
23期:8页:1250-1258
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]NATURAL-HISTORY ; HEPATOCELLULAR-CARCINOMA ; ANTIVIRAL THERAPY ; LIVER-CIRRHOSIS ; INFECTION ; SEROCONVERSION ; HBE ; PROGNOSIS
英文摘要

Aim: To compare the clinical features of hepatitis B e antigen (HBeAg)-negative and HBeAg-positive cirrhosis, and to define the survival and prognostic indicators of Chinese HBeAg-negative hepatitis B virus (HBV)-related cirrhosis.

Methods: Two hundred and seventeen patients with chronic hepatitis B cirrhosis were studied. Survival was calculated using the Kaplan-Meier method. Proportional hazards Cox regression procedure was used to identify independent predictors of survival. The relationship between HBV-DNA viral load and prognosis was also investigated.

Results: The mean follow-up time was 35 months (3-47 months). HBeAg-negative liver cirrhosis patients comprised the greatest number of cirrhosis patients. Median alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, median total leukocytes (WBC), hemoglobin (Hb), platelet (Plt) and HBV-DNA levels and the proportion of HBV-DNA > 10(5) copies/mL were lower in HBeAg-negative patients. There were fewer complications in patients treated with lamivudine than in other patients. Survival rates were significantly reduced in patients with HBeAg-negative cirrhosis (P = 0.0024). The baseline Child-Pugh scores and more than one decompensation during follow up were independent variables correlated with survival of HBeAg-negative liver cirrhosis patients (P = 0.006 and P = 0.001, respectively). The HBV-DNA viral load did not correlate with any complications or mortality rates of HBeAg-negative patients.

Conclusions: The clinical features of HBeAg-negative and -positive liver cirrhosis differ. Survival was significantly reduced for Chinese patients with HBeAg-negative than -positive cirrhosis. Factors contributing to the prognosis were baseline Child-Pugh scores and the presence of more than one decompensation during follow up.

语种英语
WOS记录号WOS:000258098700017
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62206
专题北京大学第二临床医学院_肝病科
北京大学第一临床医学院_医学统计室
北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Dept Stat, Hosp 1, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Ma, Hui,Wei, Lai,Guo, Fang,et al. Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2008,23(8):1250-1258.
APA Ma, Hui,Wei, Lai,Guo, Fang,Zhu, Sainan,Sun, Yan,&Wang, Hao.(2008).Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,23(8),1250-1258.
MLA Ma, Hui,et al."Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 23.8(2008):1250-1258.
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