|Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis|
|Ma, Hui1; Wei, Lai1; Guo, Fang1; Zhu, Sainan2; Sun, Yan1; Wang, Hao1|
|关键词||Chinese patients HBeAg negative liver cirrhosis survival|
|刊名||JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology|
|研究领域[WOS]||Gastroenterology & Hepatology|
|关键词[WOS]||NATURAL-HISTORY ; HEPATOCELLULAR-CARCINOMA ; ANTIVIRAL THERAPY ; LIVER-CIRRHOSIS ; INFECTION ; SEROCONVERSION ; HBE ; PROGNOSIS|
Aim: To compare the clinical features of hepatitis B e antigen (HBeAg)-negative and HBeAg-positive cirrhosis, and to define the survival and prognostic indicators of Chinese HBeAg-negative hepatitis B virus (HBV)-related cirrhosis.
Methods: Two hundred and seventeen patients with chronic hepatitis B cirrhosis were studied. Survival was calculated using the Kaplan-Meier method. Proportional hazards Cox regression procedure was used to identify independent predictors of survival. The relationship between HBV-DNA viral load and prognosis was also investigated.
Results: The mean follow-up time was 35 months (3-47 months). HBeAg-negative liver cirrhosis patients comprised the greatest number of cirrhosis patients. Median alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, median total leukocytes (WBC), hemoglobin (Hb), platelet (Plt) and HBV-DNA levels and the proportion of HBV-DNA > 10(5) copies/mL were lower in HBeAg-negative patients. There were fewer complications in patients treated with lamivudine than in other patients. Survival rates were significantly reduced in patients with HBeAg-negative cirrhosis (P = 0.0024). The baseline Child-Pugh scores and more than one decompensation during follow up were independent variables correlated with survival of HBeAg-negative liver cirrhosis patients (P = 0.006 and P = 0.001, respectively). The HBV-DNA viral load did not correlate with any complications or mortality rates of HBeAg-negative patients.
Conclusions: The clinical features of HBeAg-negative and -positive liver cirrhosis differ. Survival was significantly reduced for Chinese patients with HBeAg-negative than -positive cirrhosis. Factors contributing to the prognosis were baseline Child-Pugh scores and the presence of more than one decompensation during follow up.
|作者单位||1.Peking Univ, Dept Stat, Hosp 1, Beijing 100044, Peoples R China|
2.Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
|Ma, Hui,Wei, Lai,Guo, Fang,et al. Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2008,23(8):1250-1258.|
|APA||Ma, Hui,Wei, Lai,Guo, Fang,Zhu, Sainan,Sun, Yan,&Wang, Hao.(2008).Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,23(8),1250-1258.|
|MLA||Ma, Hui,et al."Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 23.8(2008):1250-1258.|