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Cerebral phaeohyphomycosis-a cure at what lengths?
Li, Dong Ming1; de Hoog, G. Sybren2
刊名LANCET INFECTIOUS DISEASES
2009-06-01
9期:6页:376-383
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; LIVER-TRANSPLANT RECIPIENT ; BANTIANA BRAIN-ABSCESS ; CLADOPHIALOPHORA-BANTIANA ; RAMICHLORIDIUM-MACKENZIEI ; XYLOHYPHA-BANTIANA ; WANGIELLA-DERMATITIDIS ; CLADOSPORIUM-TRICHOIDES ; EXOPHIALA-DERMATITIDIS ; FUNGAL-INFECTIONS
英文摘要

Cerebral phaeohyphomycosis is a fungal infection of the brain typically caused by Cladophialophora bantiana, Exophiala dermatitidis, and Rhinocladiella mackenziei, all of which belong to the order Chaetothyriales. The disease results in black, necrotic brain tissue, black pus, and black cerebrospinal fluid. Pathogens usually reach the brain through the bloodstream or lymphatic fluid and occasionally through direct spreading or accidental inoculation. Patients can present with hemiparesis, tonic spasm, headache, fever, sensory variation, cerebral irritation, and even psychotic behavioural changes. Radiological images are characterised by ring-enhanced signs and hyperdense and hypodense lesions. Pathological features frequently include black-to-brown necrotic tissue or dark-coloured pus, granulomatous inflammation, giant cell vasculitis, and pigmented fungal elements, which are easily seen on a direct potassium hydroxide smear, a rapid method for diagnosis. Black fungi can be cultured from a biopsy specimen. Combined antifungal chemotherapy, surgical debridement, and careful immunological interventions are strongly recommended to eradicate these intractable infections.

语种英语
WOS记录号WOS:000266542300015
项目编号C30570003
资助机构National Natural Science Foundation of China
引用统计
被引频次:77[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62212
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Cent Bur Schimmelcultures, Utrecht, Netherlands
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GB/T 7714
Li, Dong Ming,de Hoog, G. Sybren. Cerebral phaeohyphomycosis-a cure at what lengths?[J]. LANCET INFECTIOUS DISEASES,2009,9(6):376-383.
APA Li, Dong Ming,&de Hoog, G. Sybren.(2009).Cerebral phaeohyphomycosis-a cure at what lengths?.LANCET INFECTIOUS DISEASES,9(6),376-383.
MLA Li, Dong Ming,et al."Cerebral phaeohyphomycosis-a cure at what lengths?".LANCET INFECTIOUS DISEASES 9.6(2009):376-383.
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