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学科主题: 临床医学
题名:
Cerebral phaeohyphomycosis-a cure at what lengths?
作者: Li, Dong Ming1; de Hoog, G. Sybren2
刊名: LANCET INFECTIOUS DISEASES
发表日期: 2009-06-01
卷: 9, 期:6, 页:376-383
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; LIVER-TRANSPLANT RECIPIENT ; BANTIANA BRAIN-ABSCESS ; CLADOPHIALOPHORA-BANTIANA ; RAMICHLORIDIUM-MACKENZIEI ; XYLOHYPHA-BANTIANA ; WANGIELLA-DERMATITIDIS ; CLADOSPORIUM-TRICHOIDES ; EXOPHIALA-DERMATITIDIS ; FUNGAL-INFECTIONS
英文摘要:

Cerebral phaeohyphomycosis is a fungal infection of the brain typically caused by Cladophialophora bantiana, Exophiala dermatitidis, and Rhinocladiella mackenziei, all of which belong to the order Chaetothyriales. The disease results in black, necrotic brain tissue, black pus, and black cerebrospinal fluid. Pathogens usually reach the brain through the bloodstream or lymphatic fluid and occasionally through direct spreading or accidental inoculation. Patients can present with hemiparesis, tonic spasm, headache, fever, sensory variation, cerebral irritation, and even psychotic behavioural changes. Radiological images are characterised by ring-enhanced signs and hyperdense and hypodense lesions. Pathological features frequently include black-to-brown necrotic tissue or dark-coloured pus, granulomatous inflammation, giant cell vasculitis, and pigmented fungal elements, which are easily seen on a direct potassium hydroxide smear, a rapid method for diagnosis. Black fungi can be cultured from a biopsy specimen. Combined antifungal chemotherapy, surgical debridement, and careful immunological interventions are strongly recommended to eradicate these intractable infections.

语种: 英语
所属项目编号: C30570003
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000266542300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62212
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Cent Bur Schimmelcultures, Utrecht, Netherlands

Recommended Citation:
Li, Dong Ming,de Hoog, G. Sybren. Cerebral phaeohyphomycosis-a cure at what lengths?[J]. LANCET INFECTIOUS DISEASES,2009,9(6):376-383.
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