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学科主题: 临床医学
题名:
Multicenter clinical trial using an accelerated streptokinase regimen in patients with acute myocardial infarction
作者: Xu, CB; Zhang, T
关键词: myocardial infarction ; accelerated streptokinase ; thrombolytic therapy
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2000-08-01
卷: 113, 期:8, 页:733-736
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: LEFT-VENTRICULAR FUNCTION ; INTRAVENOUS STREPTOKINASE ; PLASMINOGEN-ACTIVATOR
英文摘要:

Objective To observe the clinical efficacy and safety of intravenous thrombolytic therapy using an accelerated streptokinase (SK) regimen in myocardial infarction (AMI).

Methods Data were collected from 40 hospitals during April 1996 to July 1997. Clinical therapeutic efficacy, five-week mortality, and adverse events were analyzed in 527 patients with AMI treated with an accelerated SK regimen (1.5 million IU within 30 min).

Results The reperfusion rate of infarct-related arteries (IRAs) was 79.7% (421/528) assessed by clinical signs. The total mortality in the first 5 weeks was 6.6% (35/527). The incidence of allergic reactions and hypotension was 3.8% (20/528) and 4.2% (22/528), respectively. The incidence of bleeding was 2.7% (14/528), including cerebral bleeding 0.8% (4/528) and other major bleeding 0.8% (4/528).

Conclusion Intravenous accelerated SK therapy can markedly improve reperfusion rate without increasing adverse events such as bleeding, allergic reactions and hypotension.

语种: 英语
WOS记录号: WOS:000088781300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62217
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Beijing Med Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Xu, CB,Zhang, T. Multicenter clinical trial using an accelerated streptokinase regimen in patients with acute myocardial infarction[J]. CHINESE MEDICAL JOURNAL,2000,113(8):733-736.
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