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学科主题: 基础医学
题名:
Distribution of enterovirus 71 RNA in inflammatory cells infiltrating different tissues in fatal cases of hand, foot, and mouth disease
作者: Yu, Pin1,2; Gao, Zifen; Zong, Yuanyuan4; Bao, Linlin1,2; Xu, Lili1,2; Deng, Wei1,2; Xu, Yanfeng1,2; Gao, Zhancheng3,5; Yao, Yanfeng1,2; Li, Fengdi1,2; Lv, Qi1,2; Qin, Chuan1,2
刊名: ARCHIVES OF VIROLOGY
发表日期: 2015
DOI: 10.1007/s00705-014-2233-x
卷: 160, 期:1, 页:81-90
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: INFECTION ; CHILDREN ; OUTBREAK ; MALAYSIA ; CHINA ; ENCEPHALOMYELITIS ; SINGAPORE ; TAIWAN
英文摘要:

In previous studies of hand, foot, and mouth disease patients fatally infected with enterovirus 71 (EV71), the distribution of viral protein, but not the genome, was determined. To understand the pathogenesis of EV71, however, it is important to investigate the spread of the viral genome. There have been no pathological studies of in situ EV71 viral RNA in inflammatory cells infiltrating various tissues of fatal cases. We therefore first investigated the distribution and classification of inflammatory cells in various tissues and then performed in situ EV71 RNA hybridization in these tissues to better understand the pathogenesis of EV71 infection. EV71 RNA was found mainly in inflammatory cells infiltrating the central nervous system (CNS), intestines, lungs, and tonsils. Most EV71 RNA-positive inflammatory cells in the CNS were macrophages/microglia and neutrophils infiltrating the perivascular cuffing, microglial nodule, neuronophagia, and meninges. CD68+ macrophages and CD15+ neutrophils were diffusely distributed in tissues with severe pathological changes. This study demonstrates the presence of EV71 RNA in inflammatory cells infiltrating tissues in fatally infected patients. Our findings suggest that fatal EV71 infection with extensive infiltration of macrophages/microglia and neutrophils into the CNS results in severe neurological lesions.

语种: 英语
所属项目编号: 81171631 ; 2011CB504903 ; 2012ZX10004501 ; 2012ZX10004301-008
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China [973 Program] ; National Science and Technology Major Projects ; National Science and Technology Major Projects of Therapy
WOS记录号: WOS:000347403200010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62223
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China
2.Minist Hlth, Key Lab Human Dis Comparat Med, PUMC, Comparat Med Ctr, Beijing 100021, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
4.Shandong Univ, Shandong Prov Hosp, Dept Pathol, Jinan 250021, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China

Recommended Citation:
Yu, Pin,Gao, Zifen,Zong, Yuanyuan,et al. Distribution of enterovirus 71 RNA in inflammatory cells infiltrating different tissues in fatal cases of hand, foot, and mouth disease[J]. ARCHIVES OF VIROLOGY,2015,160(1):81-90.
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