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Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes
Luo, Xiucui1,6; Pan, Jing1,6; Wang, Leilei1; Wang, Peirong1,3,6; Zhang, Meijiao1; Liu, Meilin1; Dong, Ziqing1; Meng, Qian1; Tao, Xuguang1,3,6; Zhao, Xinliang1,3,6; Zhong, Julia1,5; Ju, Weina2; Gu, Yang1; Jenkins, Edmund C.2; Brown, W. Ted2; Shi, Qingxi1,6; Zhong, Nanbert1,2,3,4,6,7,8
关键词Preterm birth (PTB) Preterm premature rupture of membrane (PPROM) Long non-coding RNA (lncRNA) mRNA Pathogenic mechanism
刊名BMC PREGNANCY AND CHILDBIRTH
2015-02-15
DOI10.1186/s12884-015-0460-0
15期:0
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
资助者Jiangsu Provincial Natural Science Fund ; Lianyungang Maternal and Children&prime ; s Hospital ; New York State Institute for Basic Research in Developmental Disabilities ; March of Dimes Foundation Global Network for Maternal and Infant Health ; Jiangsu Provincial Natural Science Fund ; Lianyungang Maternal and Children&prime ; s Hospital ; New York State Institute for Basic Research in Developmental Disabilities ; March of Dimes Foundation Global Network for Maternal and Infant Health
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]RECEPTOR RNA-ACTIVATOR ; LONG NONCODING RNA ; NATURAL ANTISENSE TRANSCRIPT ; APOPTOTIC DNA-DEGRADATION ; GENE-EXPRESSION ; CELL-CYCLE ; LAEVERIN/AMINOPEPTIDASE-Q ; MUSCLE DIFFERENTIATION ; DOWN-REGULATION ; BREAST CANCERS
英文摘要

Background: Preterm premature rupture of membranes (PPROM) is responsible for one third of all preterm births (PTBs). We have recently demonstrated that long noncoding RNAs (lncRNAs) are differentially expressed in human placentas derived from PPROM, PTB, premature rupture of the membranes (PROM), and full-term birth (FTB), and determined the major biological pathways involved in PPROM.

Methods: Here, we further investigated the relationship of lncRNAs, which are differentially expressed in spontaneous PTB (sPTB) and PPROM placentas and are found to overlap a coding locus, with the differential expression of transcribed mRNAs at the same locus. Ten lncRNAs (five up-regulated and five down-regulated) and the lncRNA-associated 10 mRNAs (six up-and four down-regulated), which were identified by microarray in comparing PPROM vs. sPTB, were then validated by real-time quantitative PCR.

Results: A total of 62 (38 up-and 24 down-regulated) and 1,923 (790 up- and 1,133 down-regulated) lncRNAs were identified from placentas of premature labor (sPTB + PPROM), as compared to those from full-term labor (FTB + PROM) and from premature rupture of membranes (PPROM + PROM), as compared to those from non-rupture of membranes (sPTB + FTB), respectively. We found that a correlation existed between differentially expressed lncRNAs and their associated mRNAs, which could be grouped into four categories based on the gene strand (sense or antisense) of lncRNA and its paired transcript. These findings suggest that lncRNA regulates mRNA transcription through differential mechanisms. Differential expression of the transcripts PPP2R5C, STAM, TACC2, EML4, PAM, PDE4B, STAM, PPP2R5C, PDE4B, and EGFR indicated a co-expression among these mRNAs, which are involved in the ubiquitine-proteasome system (UPS), in addition to signaling transduction and beta adrenergic signaling, suggesting that imbalanced regulation of UPS may present an additional mechanism underlying the premature rupture of membrane in PPROM.

Conclusion: Differentially expressed lncRNAs that were identified from the human placentas of sPTB and PPROM may regulate their associated mRNAs through differential mechanisms and connect the ubiquitin-proteasome system with infection-inflammation pathways. Although the detailed mechanisms by which lncRNAs regulate their associated mRNAs in sPTB and PPROM are yet to be clarified, our findings open a new approach to explore the pathogenesis of sPTB and PPROM.

语种英语
所属项目编号BK20141244
资助者Jiangsu Provincial Natural Science Fund ; Lianyungang Maternal and Children&prime ; s Hospital ; New York State Institute for Basic Research in Developmental Disabilities ; March of Dimes Foundation Global Network for Maternal and Infant Health ; Jiangsu Provincial Natural Science Fund ; Lianyungang Maternal and Children&prime ; s Hospital ; New York State Institute for Basic Research in Developmental Disabilities ; March of Dimes Foundation Global Network for Maternal and Infant Health
WOS记录号WOS:000350377400001
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62232
专题基础医学院_北京大学医学遗传中心
作者单位1.Lianyungang Maternal & Childrens Hosp Lianyungang, Ctr Translat Med Maternal & Childrens Hlth, Lianyungang, Jiangsu, Peoples R China
2.New York State Inst Basic Res Dev Disabil, Staten Isl, NY USA
3.Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China
4.Shandong Jiaotong Univ, Shanghai Childrens Hosp, Shanghai, Peoples R China
5.CUNY Hunter Coll, High Sch, New York, NY 10021 USA
6.Chinese Alliance Translat Med Maternal & Children, Beijing, Peoples R China
7.March Dimes Fdn, March Dimes Global Network Maternal & Infant Hlth, White Plains, NY USA
8.New York State Inst Basic Res Dev Disabil, Dept Human Genet, Staten Isl, NY 10314 USA
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Luo, Xiucui,Pan, Jing,Wang, Leilei,et al. Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes[J]. BMC PREGNANCY AND CHILDBIRTH,2015,15(0).
APA Luo, Xiucui.,Pan, Jing.,Wang, Leilei.,Wang, Peirong.,Zhang, Meijiao.,...&Zhong, Nanbert.(2015).Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.BMC PREGNANCY AND CHILDBIRTH,15(0).
MLA Luo, Xiucui,et al."Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes".BMC PREGNANCY AND CHILDBIRTH 15.0(2015).
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