IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics
Zhang, Hui-Juan1,3; Xue, Wei-Chen4; Siu, Michelle Kwan-Yee1; Liao, Xiao-Yun1; Ngan, Hextan Yuen-Sheung2; Cheung, Annie Nga-Yin1
关键词Gestational trophoblastic disease Gestational trophoblastic neoplasia P63
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
2009-03-01
DOI10.1097/PGP.0b013e318189555b
28期:2页:172-178
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Pathology
研究领域[WOS]Obstetrics & Gynecology ; Pathology
关键词[WOS]CLINICOPATHOLOGICAL PARAMETERS ; DIFFERENTIAL-DIAGNOSIS ; TUMOR-SUPPRESSOR ; CELL CARCINOMAS ; PLACENTAL SITE ; UP-REGULATION ; P53 ; DELTA-NP63 ; P73 ; PROTEIN
英文摘要

p63 regulates cell growth and differentiation and contributes to tumorigenesis through its complex isoforms. Gestational trophoblastic disease encompasses a heterogeneous family of lesions with different malignant potential that arise from Various trophoblast subpopulations. This study investigated the expression of p63 isoforms in various trophoblastic diseases and correlated with clinical progress, proliferation. and apoptotic activities. 4A4 and anti-p40 antibodies were applied to assess expressions of total and Delta Np63 isoforms in 20 placentas, 62 hydatidiform moles. 9 choriocarcinomas, 5 placenta site trophoblastic tumors, and 2 epithelioid trophoblastic tumors immunohistochemically. The immunoreactivity of p63 was localized to the nuclei of cytotrophoblast, villous, and chorionic-type intermediate trophoblasts with significant correlation between 2 p63 indices (P<0.001). p63 indices were significantly lower in placentas of advanced gestational age (P<0.001). Hydatidiform moles demonstrated significantly higher p63 indices than normal placentas (P<0.001). Epithelioid trophoblastic tumors displayed the highest p63 indices (45%-80%) whereas immunoreactivity was only focal in choriocarcinoma (0%-5.62%) and was essentially absent in placenta site trophoblastic tumors. There was no significant correlation between p63 indices and subsequent development of trophoblastic neoplasia in hydatidiform moles (P>0.05). Both p63 indices positively correlated with the proliferative index (Ki67) (P<0.05), apoptotic index (M30) (P<0.005) p53 (P<0.005), and p21(WAF1/CIP1) expression (P<0.005). Our results indicate that Delta Np63, the dominant isoforms expressed in trophoblasts, display heterogeneous expression patterns in relation to trophoblast subtypes. We also demonstrate for the first time the possible role of p63 in the pathogenesis of gestational trophoblastic disease (GTD) through its interaction with p53-dependent proliferation and apoptotic activities.

语种英语
WOS记录号WOS:000263624200012
项目编号HKU 7503/06M
资助机构Hong Kong Research Grant Council ; University of Hong Kong Committee for Research and Conference
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62235
专题北京大学临床肿瘤学院
作者单位1.Univ Hong Kong, Dept Pathol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Dept Obstet & Gynecol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
3.Jiao Tong Univ, Dept Pathol, Int Peace Matern & Child Hlth Hosp, Shanghai 200030, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp, Beijing Inst Canc Res,Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
Zhang, Hui-Juan,Xue, Wei-Chen,Siu, Michelle Kwan-Yee,et al. P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,2009,28(2):172-178.
APA Zhang, Hui-Juan,Xue, Wei-Chen,Siu, Michelle Kwan-Yee,Liao, Xiao-Yun,Ngan, Hextan Yuen-Sheung,&Cheung, Annie Nga-Yin.(2009).P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics.INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,28(2),172-178.
MLA Zhang, Hui-Juan,et al."P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics".INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 28.2(2009):172-178.
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