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学科主题: 临床医学
题名:
Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions
作者: Wong, Benjamin C. Y.2; Zhang, Lian1; Ma, Jun-ling1; Pan, Kai-feng1; Li, Ji-you3; Shen, Lin4; Liu, Wei-dong; Feng, Guo-shuang1; Zhang, Xiao-dong4; Li, Jie4; Lu, Ai-ping3; Xia, Harry H. X.2; Lam, Shiukum2; You, Wei-cheng1
刊名: GUT
发表日期: 2012-06-01
DOI: 10.1136/gutjnl-2011-300154
卷: 61, 期:6, 页:812-818
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; DOUBLE-BLIND ; CYCLOOXYGENASE-2 INHIBITOR ; CHINESE POPULATION ; CLINICAL-PRACTICE ; RANDOMIZED-TRIAL ; HIGH-RISK ; CANCER ; CELECOXIB ; CHEMOPREVENTION
英文摘要:

Objective Helicobacter pylori infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer and its precursors. To evaluate the effect of a selective COX-2 inhibitor alone and combined with H pylori eradication on the evolution of precancerous gastric lesions, a randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China.

Methods A total of 1024 participants aged 35-64 years with H pylori infection and advanced gastric lesions were randomly assigned in a factorial design to two interventions or placebo: anti-H pylori treatment for 7 days, and a COX-2 inhibitor (celecoxib) for 24 months. The effects of the interventions were evaluated by the regression or progression of advanced gastric lesions.

Results Of the 1024 participants who received anti-H pylori treatment or placebo, 919 completed a subsequent 24-month treatment with celecoxib or placebo. The H pylori eradication rate by per-protocol analysis was 78.2%. Compared with placebo, the proportions of regression of gastric lesions significantly increased in the celecoxib treatment (52.8% vs 41.2%) and anti-H pylori treatment (59.3% vs 41.2%) group, and OR by per-protocol analysis was 1.72 (95% CI 1.07 to 2.76) for celecoxib and 2.19 (95% CI 1.32 to 3.64) for H pylori eradication. No statistically significant effect was found for H pylori eradication followed by celecoxib on the regression of advanced gastric lesions (OR 1.48, 95% CI 0.91 to 2.40).

Conclusion This population-based intervention trial revealed that celecoxib treatment or H pylori eradication alone had beneficial effects on the regression of advanced gastric lesions. No favourable effects were seen for H pylori eradication followed by celecoxib treatment.

语种: 英语
所属项目编号: 2006AA02A402 ; 2010CB529303 ; 30471957 ; 30772515 ; HKU 7256/01M
项目资助者: National High Technology RD Program ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation ; Peking University ; Research Grant Council, Hong Kong
WOS记录号: WOS:000303997800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62238
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res,Dep Canc Ep, Beijing 100142, Peoples R China
2.Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Dept Med Oncol, Beijing 100142, Peoples R China

Recommended Citation:
Wong, Benjamin C. Y.,Zhang, Lian,Ma, Jun-ling,et al. Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions[J]. GUT,2012,61(6):812-818.
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