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学科主题: 口腔医学
题名:
Family-based association analysis of S100A8 genetic polymorphisms with aggressive periodontitis
作者: Ren, X. Y.1; Xu, L.1; Meng, H. X.1; Zhao, H. S.2; Lu, R. F.1; Chen, Z. B.1; Feng, X. H.1; Shi, D.1; Zhang, L.1; Tian, Y.1
关键词: aggressive periodontitis ; genetics ; family ; S100A8 gene
刊名: JOURNAL OF PERIODONTAL RESEARCH
发表日期: 2009-04-01
DOI: 10.1111/j.1600-0765.2008.01103.x
卷: 44, 期:2, 页:184-192
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: EARLY-ONSET PERIODONTITIS ; CALCIUM-BINDING PROTEINS ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; GINGIVAL CREVICULAR FLUID ; LINKAGE DISEQUILIBRIUM ; JUVENILE PERIODONTITIS ; DOMINANT INHERITANCE ; COLORECTAL-CARCINOMA ; EPITHELIAL-CELLS ; UNIFIED APPROACH
英文摘要:

It is known that S100A8, a member of the S100 calcium-binding protein family, is associated with inflammatory diseases, including periodontitis. Our previous population-based study found an association between two polymorphisms, rs3795391 (A > G) and rs3806232 (A > G), in the upstream region of the S100A8 gene and aggressive periodontitis (AgP) in Chinese people. Based on those results, this investigation set out to analyze and corroborate whether the association also exists within families.

Two hundred and four subjects from 73 nuclear families were recruited. All probands and their relatives were diagnosed according to the 1999 classification of periodontal diseases. Anticoagulated peripheral blood samples were collected from all the subjects, and DNA was extracted. The two single nucleotide polymorphisms (SNPs; rs3795391 and rs3806232) were detected and analyzed by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Analysis of genotype/allele was performed by Family-Based Association Test (FBAT) software (http://www.biostat.harvard.edu/fbat/default.html).

There was a statistically significant association of the SNP rs3795391 with AgP in the additive genetic model (chi(2) = 3.9836, d.f. = 1, p = 0.0459). Allele A showed significantly preferential transmission to the AgP affected individuals (Z = 1.996, p = 0.0459). The other SNP, rs3806232, showed no significant results in all models.

This family-based association study supports the previous findings that SNP rs3795391 (A > G) of the S100A8 gene might contribute to AgP susceptibility. This is, to our knowledge, the first investigation about AgP using FBAT in genetic analysis.

语种: 英语
所属项目编号: 30471882 ; 30271411 ; 30772420 ; 2002AA217091 ; 2007BAI18B02
项目资助者: National Natural Science Foundations of China ; Special Fund for Promotion of Education ; Ministry of Education PRC ; National High Tech Program ; Clinical Research Fund ; Ministry of Health PRC National Scientific and Technical Supporting Program in the 11th Five-Year Period
WOS记录号: WOS:000263602000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62242
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Human Dis Genom Ctr, Hlth Sci Ctr, Sch Basic Med Sci,Lab Med Immunol, Beijing 100081, Peoples R China

Recommended Citation:
Ren, X. Y.,Xu, L.,Meng, H. X.,et al. Family-based association analysis of S100A8 genetic polymorphisms with aggressive periodontitis[J]. JOURNAL OF PERIODONTAL RESEARCH,2009,44(2):184-192.
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