|Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure|
|Qian, Qin1; Li, Ping1; Wang, Tiancheng2; Zhang, Ji3; Yu, Shanfa4; Chen, Tian1; Yan, Lei1; Song, Yanshuang1; Liu, Xiaohua1; Gu, Yongen1; Wang, Yun1; Jia, Guang1|
|刊名||OCCUPATIONAL AND ENVIRONMENTAL MEDICINE|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||HEXAVALENT CHROMIUM ; T-CELLS ; CANCER ; WORKERS ; EXPRESSION ; SNAPSHOT ; NICKEL ; SYSTEM ; IL-10 ; LEVEL|
The role of chromate exposure in the deregulation of total lymphocyte and other immune factors is largely unclear.
We aimed to examine alteration of the Th1/Th2/Th17 cytokine profile and humoral indicators caused by occupational chromate exposure.
A cross-sectional study was conducted in two similar workshops (groups 1 and 2) with 106 male occupational workers and 50 matched local controls. Environmental and biological exposures were assessed by measuring chromium concentrations in workplace air, and in whole blood and urine samples of the workers. Cytokines in serum (IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma, IL-17A) were determined by CBA assay, while immunoglobin (IgA, IgM, IgG, IgE) and complement (C3, C4) were evaluated by immunonephelometric and ELISA methods. Micronucleus analysis was also used to explore the relationship between genotoxicity and immunotoxicity.
Compared with the control group, environmental chromate exposure in groups 1 and 2 was much higher, and the mean values of IL-6, IL-10, IFN-gamma, IL-17A and IFN-gamma/IL-4 were significantly decreased in group 1. In group 2, IgA and IgG levels were reduced, while C3 and C4 were increased. Levels of IFN-gamma, IgG and IgA were all inversely associated with whole blood chromium, while C3 and C4 were positively associated with whole blood chromium (p < 0.05). Both IL-10 and IL-17A were inversely associated with urine chromium. Correlations were also found between IL-10, IL-17A and micronucleus (r=-0.329, r=-0.312, respectively).
Occupational exposure to chromate could downregulate the cellular and humoral factors of the immune system.
|项目编号||81072281 ; 81273043 ; 200902006|
|资助机构||National Nature Science Foundation ; Ministry of Science and Technology Supporting Programme of China|
|作者单位||1.Henan Inst Occupat Med, Zhengzhou, Henan Province, Peoples R China|
2.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100191, Peoples R China
4.Ctr Dis Control & Prevent, Dept Evaluat Occupit & Environmetal Hlth, Jinan, Shandong, Peoples R China
|Qian, Qin,Li, Ping,Wang, Tiancheng,et al. Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure[J]. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,2013,70(10):697-702.|
|APA||Qian, Qin.,Li, Ping.,Wang, Tiancheng.,Zhang, Ji.,Yu, Shanfa.,...&Jia, Guang.(2013).Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure.OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,70(10),697-702.|
|MLA||Qian, Qin,et al."Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure".OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 70.10(2013):697-702.|