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Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure
Qian, Qin1; Li, Ping1; Wang, Tiancheng2; Zhang, Ji3; Yu, Shanfa4; Chen, Tian1; Yan, Lei1; Song, Yanshuang1; Liu, Xiaohua1; Gu, Yongen1; Wang, Yun1; Jia, Guang1
刊名OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
2013-10-01
DOI10.1136/oemed-2013-101421
70期:10页:697-702
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
资助者National Nature Science Foundation ; Ministry of Science and Technology Supporting Programme of China ; National Nature Science Foundation ; Ministry of Science and Technology Supporting Programme of China
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]HEXAVALENT CHROMIUM ; T-CELLS ; CANCER ; WORKERS ; EXPRESSION ; SNAPSHOT ; NICKEL ; SYSTEM ; IL-10 ; LEVEL
英文摘要

Background

The role of chromate exposure in the deregulation of total lymphocyte and other immune factors is largely unclear.

Objectives

We aimed to examine alteration of the Th1/Th2/Th17 cytokine profile and humoral indicators caused by occupational chromate exposure.

Methods

A cross-sectional study was conducted in two similar workshops (groups 1 and 2) with 106 male occupational workers and 50 matched local controls. Environmental and biological exposures were assessed by measuring chromium concentrations in workplace air, and in whole blood and urine samples of the workers. Cytokines in serum (IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma, IL-17A) were determined by CBA assay, while immunoglobin (IgA, IgM, IgG, IgE) and complement (C3, C4) were evaluated by immunonephelometric and ELISA methods. Micronucleus analysis was also used to explore the relationship between genotoxicity and immunotoxicity.

Results

Compared with the control group, environmental chromate exposure in groups 1 and 2 was much higher, and the mean values of IL-6, IL-10, IFN-gamma, IL-17A and IFN-gamma/IL-4 were significantly decreased in group 1. In group 2, IgA and IgG levels were reduced, while C3 and C4 were increased. Levels of IFN-gamma, IgG and IgA were all inversely associated with whole blood chromium, while C3 and C4 were positively associated with whole blood chromium (p < 0.05). Both IL-10 and IL-17A were inversely associated with urine chromium. Correlations were also found between IL-10, IL-17A and micronucleus (r=-0.329, r=-0.312, respectively).

Conclusions

Occupational exposure to chromate could downregulate the cellular and humoral factors of the immune system.

语种英语
所属项目编号81072281 ; 81273043 ; 200902006
资助者National Nature Science Foundation ; Ministry of Science and Technology Supporting Programme of China ; National Nature Science Foundation ; Ministry of Science and Technology Supporting Programme of China
WOS记录号WOS:000324421200005
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62243
Collection北京大学公共卫生学院
作者单位1.Henan Inst Occupat Med, Zhengzhou, Henan Province, Peoples R China
2.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100191, Peoples R China
4.Ctr Dis Control & Prevent, Dept Evaluat Occupit & Environmetal Hlth, Jinan, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Qian, Qin,Li, Ping,Wang, Tiancheng,et al. Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure[J]. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,2013,70(10):697-702.
APA Qian, Qin.,Li, Ping.,Wang, Tiancheng.,Zhang, Ji.,Yu, Shanfa.,...&Jia, Guang.(2013).Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure.OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,70(10),697-702.
MLA Qian, Qin,et al."Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure".OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 70.10(2013):697-702.
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