北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 消化科  > 期刊论文
学科主题: 临床医学
题名:
A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer A Randomized Double-Blind Multicenter Trial
作者: Wang, Ling1; Zhou, Liya2; Lin, Sanren2; Hu, Haitang3; Xia, Jielai1
关键词: ilaprazole ; PPI ; duodenal ulcer ; acid suppression ; randomized trial
刊名: JOURNAL OF CLINICAL GASTROENTEROLOGY
发表日期: 2011-04-01
DOI: 10.1097/MCG.0b013e3181e88515
卷: 45, 期:4, 页:322-329
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: GASTROESOPHAGEAL-REFLUX DISEASE ; HELICOBACTER-PYLORI INFECTION ; PANTOPRAZOLE
英文摘要:

Goals: To investigate the efficacy and safety of a new proton pump inhibitor (PPI), ilaprazole (IY-81149) in the treatment of duodenal ulcers and provide some characteristics of the dose-response relationship for later studies.

Background: PPIs have been used therapeutically for many years, and shown great efficacy in accelerating ulcer healing. Currently researches are focused on more potent PPIs. Some preclinical studies have shown that ilaprazole might be such a new substitute.

Study: 235 patients with at least 1 endoscopically diagnosed active duodenal ulcer were enrolled in a randomized trial. Patients were randomized into 4 groups (5, 10, and 20 mg/d ilaprazole, with 20 mg/d omeprazole as positive control) and treated for up to 4 weeks. Forty patients accepted continuous 24-hour pH measurements after the fifth dose. The primary endpoint was ulcer healing rate at week 4.

Results: The efficacy analyses were based on 235 patients. At week 4, 86.4%, 93.1%, 86.4%, and 89.8% patients treated with 5mg ilaprazole, 10mg ilaprazole, 20 mg ilaprazole, and 20mg omeprazole once daily, respectively had ulcers healed (P=0.59). The majority of patients (> 70%) became asymptomatic after 4 weeks treatment. Both drugs with stipulated dosages exhibited similar efficacy and safety profiles. Gastric acid suppression increased with increasing dose of ilaprazole in pH study.

Conclusions: Ilaprazole is as tolerable, safe, and efficacious as omeprazole in the treatment of duodenal ulcers, especially at a lower dose (10 mg/d ilaprazole vs. 20 mg/d omeprazole). (Clinical-Trials.gov ID: NCT00953381).

语种: 英语
项目资助者: Livzon Pharmaceutical Group Inc. (China)
WOS记录号: WOS:000288198100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62244
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Livzon Pharmaceut Inst, Zhuhai, Guangdong, Peoples R China
2.Fourth Mil Med Univ, Dept Hlth Stat, Xian 710032, Shaanxi, Peoples R China
3.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Ling,Zhou, Liya,Lin, Sanren,et al. A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer A Randomized Double-Blind Multicenter Trial[J]. JOURNAL OF CLINICAL GASTROENTEROLOGY,2011,45(4):322-329.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Ling]'s Articles
[Zhou, Liya]'s Articles
[Lin, Sanren]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Ling]‘s Articles
[Zhou, Liya]‘s Articles
[Lin, Sanren]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace