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学科主题临床医学
A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer A Randomized Double-Blind Multicenter Trial
Wang, Ling1; Zhou, Liya2; Lin, Sanren2; Hu, Haitang3; Xia, Jielai1
关键词ilaprazole PPI duodenal ulcer acid suppression randomized trial
刊名JOURNAL OF CLINICAL GASTROENTEROLOGY
2011-04-01
DOI10.1097/MCG.0b013e3181e88515
45期:4页:322-329
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]GASTROESOPHAGEAL-REFLUX DISEASE ; HELICOBACTER-PYLORI INFECTION ; PANTOPRAZOLE
英文摘要

Goals: To investigate the efficacy and safety of a new proton pump inhibitor (PPI), ilaprazole (IY-81149) in the treatment of duodenal ulcers and provide some characteristics of the dose-response relationship for later studies.

Background: PPIs have been used therapeutically for many years, and shown great efficacy in accelerating ulcer healing. Currently researches are focused on more potent PPIs. Some preclinical studies have shown that ilaprazole might be such a new substitute.

Study: 235 patients with at least 1 endoscopically diagnosed active duodenal ulcer were enrolled in a randomized trial. Patients were randomized into 4 groups (5, 10, and 20 mg/d ilaprazole, with 20 mg/d omeprazole as positive control) and treated for up to 4 weeks. Forty patients accepted continuous 24-hour pH measurements after the fifth dose. The primary endpoint was ulcer healing rate at week 4.

Results: The efficacy analyses were based on 235 patients. At week 4, 86.4%, 93.1%, 86.4%, and 89.8% patients treated with 5mg ilaprazole, 10mg ilaprazole, 20 mg ilaprazole, and 20mg omeprazole once daily, respectively had ulcers healed (P=0.59). The majority of patients (> 70%) became asymptomatic after 4 weeks treatment. Both drugs with stipulated dosages exhibited similar efficacy and safety profiles. Gastric acid suppression increased with increasing dose of ilaprazole in pH study.

Conclusions: Ilaprazole is as tolerable, safe, and efficacious as omeprazole in the treatment of duodenal ulcers, especially at a lower dose (10 mg/d ilaprazole vs. 20 mg/d omeprazole). (Clinical-Trials.gov ID: NCT00953381).

语种英语
WOS记录号WOS:000288198100006
资助机构Livzon Pharmaceutical Group Inc. (China)
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62244
专题北京大学第三临床医学院_消化科
作者单位1.Livzon Pharmaceut Inst, Zhuhai, Guangdong, Peoples R China
2.Fourth Mil Med Univ, Dept Hlth Stat, Xian 710032, Shaanxi, Peoples R China
3.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Ling,Zhou, Liya,Lin, Sanren,et al. A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer A Randomized Double-Blind Multicenter Trial[J]. JOURNAL OF CLINICAL GASTROENTEROLOGY,2011,45(4):322-329.
APA Wang, Ling,Zhou, Liya,Lin, Sanren,Hu, Haitang,&Xia, Jielai.(2011).A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer A Randomized Double-Blind Multicenter Trial.JOURNAL OF CLINICAL GASTROENTEROLOGY,45(4),322-329.
MLA Wang, Ling,et al."A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer A Randomized Double-Blind Multicenter Trial".JOURNAL OF CLINICAL GASTROENTEROLOGY 45.4(2011):322-329.
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