|Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator|
|Fang, Liping1,3; Zhao, Jing2; Chen, Yu2; Ma, Tiemin2; Xu, Guoheng2; Tang, Chaoshu1,2; Liu, Xinmin3; Geng, Bin1,2|
|关键词||adipocyte-derived relaxing factor cystathionine gamma-lyase hydrogen sulfide hypertension periadventitial adipose tissue|
|刊名||JOURNAL OF HYPERTENSION|
|WOS标题词||Science & Technology|
|类目[WOS]||Peripheral Vascular Disease|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||SPONTANEOUSLY HYPERTENSIVE-RATS ; VASCULAR FUNCTION ; MESENTERIC-ARTERIES ; NITRIC-OXIDE ; HOMOCYSTEINE ; PATHOGENESIS ; CONTRACTION ; MODULATION ; MECHANISMS ; PEROXIDE|
Background Recently, periadventitial adipose tissue (PAT) was found to secrete bioactive factors playing an important role in the regulation of vascular tension. Hydrogen sulfide (H(2)S), a novel cardiovascular gasotransmitter, relaxes vessels through the K(ATP) channel in a calcium-dependent and endothelial-independent manner.
Methods We first identified the endogenous H(2)S-generated key enzyme cystathionase (CSE) expressed in adipocytes of PAT and H(2)S released from PAT in rats.
Results The CSE inhibitors DL-propargylglycine and/or beta-cyano-L-alanine largely blocked the vasorelaxing effects on aorta rings (removed adventitia), induced by PAT, the culture medium of PAT or isolated adipocytes from PAT. Phenylephrine, serotonin and angiotensin II inhibited endogenous H(2)S production from the aortic medium but increased its release from PAT. Endogenous H(2)S generated in the aorta and PAT was decreased but the level of CSE protein was increased with the aging of rats. In rats with hypertension induced by abdominal aortic banding, H(2)S generation and CSE protein expression were significantly increased in PAT but not aortic tissues. Transplanting PAT into periadventitia of stenotic aortas ameliorated the elevated arterial blood pressure and decreased angiotensin II level in aorta.
Conclusion These results suggested PAT could endogenously generate H(2)S, which might act as an adipocyte-derived relaxing factor and contribute to the pathogenesis of hypertension. J Hypertens 27: 2174-2185 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
|作者单位||1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Geriatr Med, Beijing 100034, Peoples R China
|Fang, Liping,Zhao, Jing,Chen, Yu,et al. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator[J]. JOURNAL OF HYPERTENSION,2009,27(11):2174-U3.|
|APA||Fang, Liping.,Zhao, Jing.,Chen, Yu.,Ma, Tiemin.,Xu, Guoheng.,...&Geng, Bin.(2009).Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator.JOURNAL OF HYPERTENSION,27(11),2174-U3.|
|MLA||Fang, Liping,et al."Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator".JOURNAL OF HYPERTENSION 27.11(2009):2174-U3.|