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学科主题: 临床医学
题名:
Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator
作者: Fang, Liping1,3; Zhao, Jing2; Chen, Yu2; Ma, Tiemin2; Xu, Guoheng2; Tang, Chaoshu1,2; Liu, Xinmin3; Geng, Bin1,2
关键词: adipocyte-derived relaxing factor ; cystathionine gamma-lyase ; hydrogen sulfide ; hypertension ; periadventitial adipose tissue
刊名: JOURNAL OF HYPERTENSION
发表日期: 2009-11-01
DOI: 10.1097/HJH.0b013e328330a900
卷: 27, 期:11, 页:2174-U3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: SPONTANEOUSLY HYPERTENSIVE-RATS ; VASCULAR FUNCTION ; MESENTERIC-ARTERIES ; NITRIC-OXIDE ; HOMOCYSTEINE ; PATHOGENESIS ; CONTRACTION ; MODULATION ; MECHANISMS ; PEROXIDE
英文摘要:

Background Recently, periadventitial adipose tissue (PAT) was found to secrete bioactive factors playing an important role in the regulation of vascular tension. Hydrogen sulfide (H(2)S), a novel cardiovascular gasotransmitter, relaxes vessels through the K(ATP) channel in a calcium-dependent and endothelial-independent manner.

Methods We first identified the endogenous H(2)S-generated key enzyme cystathionase (CSE) expressed in adipocytes of PAT and H(2)S released from PAT in rats.

Results The CSE inhibitors DL-propargylglycine and/or beta-cyano-L-alanine largely blocked the vasorelaxing effects on aorta rings (removed adventitia), induced by PAT, the culture medium of PAT or isolated adipocytes from PAT. Phenylephrine, serotonin and angiotensin II inhibited endogenous H(2)S production from the aortic medium but increased its release from PAT. Endogenous H(2)S generated in the aorta and PAT was decreased but the level of CSE protein was increased with the aging of rats. In rats with hypertension induced by abdominal aortic banding, H(2)S generation and CSE protein expression were significantly increased in PAT but not aortic tissues. Transplanting PAT into periadventitia of stenotic aortas ameliorated the elevated arterial blood pressure and decreased angiotensin II level in aorta.

Conclusion These results suggested PAT could endogenously generate H(2)S, which might act as an adipocyte-derived relaxing factor and contribute to the pathogenesis of hypertension. J Hypertens 27: 2174-2185 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 2006CB503807 ; 2009CB941603 ; 30400151 ; 30572072
项目资助者: Major State Basic Research Development Program of the People&prime ; s Republic of China ; National Basic Research Program of China ; National Natural Science Foundation of the People&prime ; s Republic China
WOS记录号: WOS:000271614800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62249
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Geriatr Med, Beijing 100034, Peoples R China

Recommended Citation:
Fang, Liping,Zhao, Jing,Chen, Yu,et al. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator[J]. JOURNAL OF HYPERTENSION,2009,27(11):2174-U3.
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