IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator
Fang, Liping1,3; Zhao, Jing2; Chen, Yu2; Ma, Tiemin2; Xu, Guoheng2; Tang, Chaoshu1,2; Liu, Xinmin3; Geng, Bin1,2
关键词adipocyte-derived relaxing factor cystathionine gamma-lyase hydrogen sulfide hypertension periadventitial adipose tissue
刊名JOURNAL OF HYPERTENSION
2009-11-01
DOI10.1097/HJH.0b013e328330a900
27期:11页:2174-U3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]SPONTANEOUSLY HYPERTENSIVE-RATS ; VASCULAR FUNCTION ; MESENTERIC-ARTERIES ; NITRIC-OXIDE ; HOMOCYSTEINE ; PATHOGENESIS ; CONTRACTION ; MODULATION ; MECHANISMS ; PEROXIDE
英文摘要

Background Recently, periadventitial adipose tissue (PAT) was found to secrete bioactive factors playing an important role in the regulation of vascular tension. Hydrogen sulfide (H(2)S), a novel cardiovascular gasotransmitter, relaxes vessels through the K(ATP) channel in a calcium-dependent and endothelial-independent manner.

Methods We first identified the endogenous H(2)S-generated key enzyme cystathionase (CSE) expressed in adipocytes of PAT and H(2)S released from PAT in rats.

Results The CSE inhibitors DL-propargylglycine and/or beta-cyano-L-alanine largely blocked the vasorelaxing effects on aorta rings (removed adventitia), induced by PAT, the culture medium of PAT or isolated adipocytes from PAT. Phenylephrine, serotonin and angiotensin II inhibited endogenous H(2)S production from the aortic medium but increased its release from PAT. Endogenous H(2)S generated in the aorta and PAT was decreased but the level of CSE protein was increased with the aging of rats. In rats with hypertension induced by abdominal aortic banding, H(2)S generation and CSE protein expression were significantly increased in PAT but not aortic tissues. Transplanting PAT into periadventitia of stenotic aortas ameliorated the elevated arterial blood pressure and decreased angiotensin II level in aorta.

Conclusion These results suggested PAT could endogenously generate H(2)S, which might act as an adipocyte-derived relaxing factor and contribute to the pathogenesis of hypertension. J Hypertens 27: 2174-2185 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000271614800004
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62249
专题北京大学第一临床医学院_心血管内科
北京大学基础医学院
北京大学第一临床医学院_老年病内科
北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Geriatr Med, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Fang, Liping,Zhao, Jing,Chen, Yu,et al. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator[J]. JOURNAL OF HYPERTENSION,2009,27(11):2174-U3.
APA Fang, Liping.,Zhao, Jing.,Chen, Yu.,Ma, Tiemin.,Xu, Guoheng.,...&Geng, Bin.(2009).Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator.JOURNAL OF HYPERTENSION,27(11),2174-U3.
MLA Fang, Liping,et al."Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator".JOURNAL OF HYPERTENSION 27.11(2009):2174-U3.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fang, Liping]的文章
[Zhao, Jing]的文章
[Chen, Yu]的文章
百度学术
百度学术中相似的文章
[Fang, Liping]的文章
[Zhao, Jing]的文章
[Chen, Yu]的文章
必应学术
必应学术中相似的文章
[Fang, Liping]的文章
[Zhao, Jing]的文章
[Chen, Yu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。