IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤外科
学科主题临床医学
Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer
Fan, Biao1; Zhang, Lian-Hai1; Jia, Yong-ning1; Zhong, Xi-Yao1; Liu, Yi-Qiang2; Cheng, Xiao-Jing3; Wang, Xiao-Hong3; Xing, Xiao-Fang3; Hu, Ying4; Li, Ying-Ai4; Du, Hong4; Zhao, Wei5; Niu, Zhao-Jian; Lu, Ai-Ping2; Li, Ji-You2; Ji, Jia-Fu1
关键词Gastric cancer S100A9 Inflammatory cells Tumor staging Survival
刊名BMC CANCER
2012-07-28
DOI10.1186/1471-2407-12-316
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]INVASIVE DUCTAL CARCINOMA ; CALCIUM-BINDING PROTEINS ; S100 PROTEINS ; CALPROTECTIN S100A8/S100A9 ; COMPLEX-FORMATION ; BOWEL-DISEASE ; EXPRESSION ; MONOCYTES ; IMMUNITY ; MARKERS
英文摘要

Background: S100A9 was originally discovered as a factor secreted by inflammatory cells. Recently, S100A9 was found to be associated with several human malignancies. The purpose of this study is to investigate S100A9 expression in gastric cancer and explore its role in cancer progression.

Methods: S100A9 expression in gastric tissue samples from 177 gastric cancer patients was assessed by immunohistochemistry. The expression of its dimerization partner S100A8 and the S100A8/A9 heterodimer were also assessed by the same method. The effect of exogenous S100A9 on motility of gastric cancer cells AGS and BGC-823 was then investigated.

Results: S100A9 was specifically expressed by inflammatory cells such as macrophages and neutrophils in human gastric cancer and gastritis tissues. Statistical analysis showed that a high S100A9 cell count (>=200) per 200x magnification microscopic field in cancer tissues was predictive of early stage gastric cancer. High S100A9-positive cell count was negatively correlated with lymph node metastasis (P=0.009) and tumor invasion (P=0.011). S100A9 was identified as an independent prognostic predictor of overall survival of patients with gastric cancer (P=0.04). Patients with high S100A9 cell count were with favorable prognosis (P=0.021). Further investigation found that S100A8 distribution in human gastric cancer tissues was similar to S100A9. However, the number of S100A8-positive cells did not positively correlate with patient survival. The inflammatory cells infiltrating cancer were S100A8/A9 negative, while those in gastritis were positive. Furthermore, exogenous S100A9 protein inhibited migration and invasion of gastric cancer cells.

Conclusions: Our results suggested S100A9-positive inflammatory cells in gastric cancer tissues are associated with early stage of gastric cancer and good prognosis.

语种英语
WOS记录号WOS:000310062800001
项目编号30471677 ; 81141024 ; 2011ZX09307-001-05
资助机构National Natural Science Foundation of China ; National Key Technology RD Program
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62253
专题北京大学临床肿瘤学院_肿瘤外科
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_标本库
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Clin Gastr Canc Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Tissue Bank, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Clin Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Fan, Biao,Zhang, Lian-Hai,Jia, Yong-ning,et al. Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer[J]. BMC CANCER,2012,12.
APA Fan, Biao.,Zhang, Lian-Hai.,Jia, Yong-ning.,Zhong, Xi-Yao.,Liu, Yi-Qiang.,...&Ji, Jia-Fu.(2012).Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer.BMC CANCER,12.
MLA Fan, Biao,et al."Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer".BMC CANCER 12(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fan, Biao]的文章
[Zhang, Lian-Hai]的文章
[Jia, Yong-ning]的文章
百度学术
百度学术中相似的文章
[Fan, Biao]的文章
[Zhang, Lian-Hai]的文章
[Jia, Yong-ning]的文章
必应学术
必应学术中相似的文章
[Fan, Biao]的文章
[Zhang, Lian-Hai]的文章
[Jia, Yong-ning]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。