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IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤外科  > 期刊论文
学科主题: 临床医学
题名:
Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer
作者: Fan, Biao1; Zhang, Lian-Hai1; Jia, Yong-ning1; Zhong, Xi-Yao1; Liu, Yi-Qiang2; Cheng, Xiao-Jing3; Wang, Xiao-Hong3; Xing, Xiao-Fang3; Hu, Ying4; Li, Ying-Ai4; Du, Hong4; Zhao, Wei5; Niu, Zhao-Jian; Lu, Ai-Ping2; Li, Ji-You2; Ji, Jia-Fu1
关键词: Gastric cancer ; S100A9 ; Inflammatory cells ; Tumor staging ; Survival
刊名: BMC CANCER
发表日期: 2012-07-28
DOI: 10.1186/1471-2407-12-316
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: INVASIVE DUCTAL CARCINOMA ; CALCIUM-BINDING PROTEINS ; S100 PROTEINS ; CALPROTECTIN S100A8/S100A9 ; COMPLEX-FORMATION ; BOWEL-DISEASE ; EXPRESSION ; MONOCYTES ; IMMUNITY ; MARKERS
英文摘要:

Background: S100A9 was originally discovered as a factor secreted by inflammatory cells. Recently, S100A9 was found to be associated with several human malignancies. The purpose of this study is to investigate S100A9 expression in gastric cancer and explore its role in cancer progression.

Methods: S100A9 expression in gastric tissue samples from 177 gastric cancer patients was assessed by immunohistochemistry. The expression of its dimerization partner S100A8 and the S100A8/A9 heterodimer were also assessed by the same method. The effect of exogenous S100A9 on motility of gastric cancer cells AGS and BGC-823 was then investigated.

Results: S100A9 was specifically expressed by inflammatory cells such as macrophages and neutrophils in human gastric cancer and gastritis tissues. Statistical analysis showed that a high S100A9 cell count (>=200) per 200x magnification microscopic field in cancer tissues was predictive of early stage gastric cancer. High S100A9-positive cell count was negatively correlated with lymph node metastasis (P=0.009) and tumor invasion (P=0.011). S100A9 was identified as an independent prognostic predictor of overall survival of patients with gastric cancer (P=0.04). Patients with high S100A9 cell count were with favorable prognosis (P=0.021). Further investigation found that S100A8 distribution in human gastric cancer tissues was similar to S100A9. However, the number of S100A8-positive cells did not positively correlate with patient survival. The inflammatory cells infiltrating cancer were S100A8/A9 negative, while those in gastritis were positive. Furthermore, exogenous S100A9 protein inhibited migration and invasion of gastric cancer cells.

Conclusions: Our results suggested S100A9-positive inflammatory cells in gastric cancer tissues are associated with early stage of gastric cancer and good prognosis.

语种: 英语
所属项目编号: 30471677 ; 81141024 ; 2011ZX09307-001-05
项目资助者: National Natural Science Foundation of China ; National Key Technology RD Program
WOS记录号: WOS:000310062800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62253
Appears in Collections:北京大学临床肿瘤学院_肿瘤外科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Clin Gastr Canc Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Tissue Bank, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Clin Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Fan, Biao,Zhang, Lian-Hai,Jia, Yong-ning,et al. Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer[J]. BMC CANCER,2012,12.
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