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学科主题: 药学
题名:
Julibroside J(8)-induced HeLa cell apoptosis through caspase pathway
作者: Zheng, L.; Zheng, J.; Wu, L. -J.; Zhao, Y. -Y.
关键词: Julibroside J(8) ; HeLa cell ; apoptosis ; caspase ; bax
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2006-07-01
DOI: 10.1080/10286020500173309
卷: 8, 期:5, 页:457-465
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ALBIZIA-JULIBRISSIN ; ACTIVATION ; SAPONINS ; DEATH
英文摘要:

The julibroside J(8) was isolated from the Albizia julibrissin and evaluated for antiproliferatived on six cancer cell lines (BGC-823, Bel-7402, HeLa, PC-3MIE8, MDA-MB-435 and LH-60) in vitro. Julibroside J(8) at 100 mu g mL(-1) (46.08 mu mol(.)L(-1)) significantly inhibited growth in the first three cell lines. In addition, in HeLa cells typical apoptotic changes in morphology were observed, and further, nuclear damage was observed by Giemsa staining and DNA fragmentation was exhibited. Effects of julibroside J(8) on induction of DNA fragmentation, caspase-3 activation and downregulation of ICAD expression were effectively inhibited by a caspase-3 inhibitor, z-DEVD-fmk. In addition, apoptosis induced with julibroside J(8) was associated with an increase in expression of the apoptosis inducer Bax, and a significant reduction in expression of the apoptosis suppressor Bcl-2 in mitochondria. These results suggest that julibroside J(8) induces HeLa death through caspase pathway.

语种: 英语
WOS记录号: WOS:000239153600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62254
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

Recommended Citation:
Zheng, L.,Zheng, J.,Wu, L. -J.,et al. Julibroside J(8)-induced HeLa cell apoptosis through caspase pathway[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2006,8(5):457-465.
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