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Julibroside J(8)-induced HeLa cell apoptosis through caspase pathway
Zheng, L.; Zheng, J.; Wu, L. -J.; Zhao, Y. -Y.
关键词Julibroside J(8) HeLa cell apoptosis caspase bax
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2006-07-01
DOI10.1080/10286020500173309
8期:5页:457-465
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]ALBIZIA-JULIBRISSIN ; ACTIVATION ; SAPONINS ; DEATH
英文摘要

The julibroside J(8) was isolated from the Albizia julibrissin and evaluated for antiproliferatived on six cancer cell lines (BGC-823, Bel-7402, HeLa, PC-3MIE8, MDA-MB-435 and LH-60) in vitro. Julibroside J(8) at 100 mu g mL(-1) (46.08 mu mol(.)L(-1)) significantly inhibited growth in the first three cell lines. In addition, in HeLa cells typical apoptotic changes in morphology were observed, and further, nuclear damage was observed by Giemsa staining and DNA fragmentation was exhibited. Effects of julibroside J(8) on induction of DNA fragmentation, caspase-3 activation and downregulation of ICAD expression were effectively inhibited by a caspase-3 inhibitor, z-DEVD-fmk. In addition, apoptosis induced with julibroside J(8) was associated with an increase in expression of the apoptosis inducer Bax, and a significant reduction in expression of the apoptosis suppressor Bcl-2 in mitochondria. These results suggest that julibroside J(8) induces HeLa death through caspase pathway.

语种英语
WOS记录号WOS:000239153600012
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62254
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
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GB/T 7714
Zheng, L.,Zheng, J.,Wu, L. -J.,et al. Julibroside J(8)-induced HeLa cell apoptosis through caspase pathway[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2006,8(5):457-465.
APA Zheng, L.,Zheng, J.,Wu, L. -J.,&Zhao, Y. -Y..(2006).Julibroside J(8)-induced HeLa cell apoptosis through caspase pathway.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,8(5),457-465.
MLA Zheng, L.,et al."Julibroside J(8)-induced HeLa cell apoptosis through caspase pathway".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 8.5(2006):457-465.
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