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Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction
Xu, Yongde1; Lei, Hongen1; Guan, Ruili1; Gao, Zhezhu1; Li, Huixi1; Wang, Lin1; Hui, Yu2; Zhou, Feng2; Xin, Zhongcheng1
关键词streptozotocin spermatogenic dysfunction IcarisideII oxidative stress diabetes mellitus
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2014-09-01
DOI10.3390/ijms150916100
15期:9页:16100-16113
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]IMPROVING ERECTILE FUNCTION ; OXIDATIVE STRESS ; DIABETES-MELLITUS ; SERTOLI-CELL ; RATS ; IMPAIRMENTS ; ANTIOXIDANT ; APOPTOSIS ; VIMENTIN ; ICARIIN
英文摘要

The aim of this study was to investigate the effects of IcarisideII(ICAII) on the prevention of streptozotocin (STZ) induced spermatogenic dysfunction. Forty male Sprague-Dawley rats received intraperitoneal injection of STZ (55 mg/kg) and were equally randomized to gavage feeding of vehicle (the vehicle group) or ICAII (0.5, 1.5 or 4.5 mg/kg/day, respectively). Ten normal rats received vehicle and served as control. Four weeks later, sperm parameters, histopathological changes, testicular lipid peroxidation, antioxidant enzyme activities, and apoptosis index (AI) were evaluated. Results showed that ICAII treatment resulted in a significant recovery of sperm parameters and histopathological changes relative to the vehicle group (p < 0.05). In the vehicle group, antioxidant enzyme activities and the expression of Sertoli cell Vimentin filaments obviously decreased, while lipid peroxidation and AI significantly increased as compared with the control group (p < 0.05). Following ICAII treatment, corrective effects on these items towards normal levels were observed. The results suggested that ICAII has beneficial effect on the preservation of spermatogenic function in the STZ-induced diabetic rats. The mechanisms might be related to its improvement of antioxidant enzyme activities, preservation of the protein expression and apical extensions of Vimentin filaments, and anti-apoptosis capability.

语种英语
WOS记录号WOS:000343109700073
项目编号81272531 ; 81300478 ; BK20130269
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62266
专题北京大学第一临床医学院_男科中心
作者单位1.Peking Univ, Hosp 1, Androl Ctr, Mol Biol Lab, Beijing 100034, Peoples R China
2.Soochow Univ, Dept Urol, Affiliated Hosp 1, Suzhou 215006, Peoples R China
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GB/T 7714
Xu, Yongde,Lei, Hongen,Guan, Ruili,et al. Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(9):16100-16113.
APA Xu, Yongde.,Lei, Hongen.,Guan, Ruili.,Gao, Zhezhu.,Li, Huixi.,...&Xin, Zhongcheng.(2014).Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,15(9),16100-16113.
MLA Xu, Yongde,et al."Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15.9(2014):16100-16113.
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