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学科主题: 临床医学
题名:
Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction
作者: Xu, Yongde1; Lei, Hongen1; Guan, Ruili1; Gao, Zhezhu1; Li, Huixi1; Wang, Lin1; Hui, Yu2; Zhou, Feng2; Xin, Zhongcheng1
关键词: streptozotocin ; spermatogenic dysfunction ; IcarisideII ; oxidative stress ; diabetes mellitus
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2014-09-01
DOI: 10.3390/ijms150916100
卷: 15, 期:9, 页:16100-16113
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: IMPROVING ERECTILE FUNCTION ; OXIDATIVE STRESS ; DIABETES-MELLITUS ; SERTOLI-CELL ; RATS ; IMPAIRMENTS ; ANTIOXIDANT ; APOPTOSIS ; VIMENTIN ; ICARIIN
英文摘要:

The aim of this study was to investigate the effects of IcarisideII(ICAII) on the prevention of streptozotocin (STZ) induced spermatogenic dysfunction. Forty male Sprague-Dawley rats received intraperitoneal injection of STZ (55 mg/kg) and were equally randomized to gavage feeding of vehicle (the vehicle group) or ICAII (0.5, 1.5 or 4.5 mg/kg/day, respectively). Ten normal rats received vehicle and served as control. Four weeks later, sperm parameters, histopathological changes, testicular lipid peroxidation, antioxidant enzyme activities, and apoptosis index (AI) were evaluated. Results showed that ICAII treatment resulted in a significant recovery of sperm parameters and histopathological changes relative to the vehicle group (p < 0.05). In the vehicle group, antioxidant enzyme activities and the expression of Sertoli cell Vimentin filaments obviously decreased, while lipid peroxidation and AI significantly increased as compared with the control group (p < 0.05). Following ICAII treatment, corrective effects on these items towards normal levels were observed. The results suggested that ICAII has beneficial effect on the preservation of spermatogenic function in the STZ-induced diabetic rats. The mechanisms might be related to its improvement of antioxidant enzyme activities, preservation of the protein expression and apical extensions of Vimentin filaments, and anti-apoptosis capability.

语种: 英语
所属项目编号: 81272531 ; 81300478 ; BK20130269
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province
WOS记录号: WOS:000343109700073
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62266
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Androl Ctr, Mol Biol Lab, Beijing 100034, Peoples R China
2.Soochow Univ, Dept Urol, Affiliated Hosp 1, Suzhou 215006, Peoples R China

Recommended Citation:
Xu, Yongde,Lei, Hongen,Guan, Ruili,et al. Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(9):16100-16113.
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