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Cytotoxicity of Silver Nanoparticles in Human Embryonic Stem Cell-Derived Fibroblasts and an L-929 Cell Line
Peng, Hui1,2; Zhang, Xuehui1,2; Wei, Yan1,2; Liu, Wentao1,2; Li, Shenglin3,4,5,6; Yu, Guangyan7,8; Fu, Xin9; Cao, Tong9; Deng, Xuliang1,2
刊名JOURNAL OF NANOMATERIALS
2012
DOI10.1155/2012/160145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]DENDRITIC CELLS ; QUANTUM-DOT ; EMBRYOTOXICITY ; GENOTOXICITY ; MECHANISMS ; TOXICITY ; RATS ; SIZE
英文摘要

Consensus about the toxicity of silver nanoparticles (Ag-NPs) has not been reached, even though extensive attention has been paid to this issue. This confusion may be due to physicochemical factors of Ag-NPs and the cell model used for biological safety evaluation. In the present study, human embryonic stem cell-derived fibroblasts (EBFs), which have been considered a closer representative of the in vivo response, were used as a novel cell model to assess the cytotoxicity of Ag-NPs (similar to 20 nm and similar to 100 nm) in comparison with L-929 fibroblast cell line. Cell proliferation, cell cycle, apoptosis, p53 expression, and cellular uptake were examined. Results showed that Ag-NPs presented higher cytotoxicity to EBF than to L-929. EBF demonstrated a stronger capacity to ingest Ag-NPs, a higher G2/M arrest, and more upgraduated p53 expression after exposed to Ag-NPs for 48 h when compared with L-929. It could be concluded that EBF exhibited a more sensitive response to Ag-NPs compared with L-929 cells, indicating that EBF may be a valid candidate for cytotoxicity screening assays of nanoparticles.

语种英语
WOS记录号WOS:000307658700001
项目编号2012CB933904 ; 81171000 ; 2011DFA32190
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; International S&amp ; T Cooperation Program of China (ISTCP)
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62269
专题北京大学口腔医学院
北京大学第一临床医学院_超声诊断中心
北京大学口腔医学院_特诊科
北京大学口腔医学院_第三门诊部
北京大学口腔医学院_外科
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Peking Univ, Dept Geriatr Dent, Sch Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Geriatr Dent, Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Cent Lab, Sch Stomatol, Beijing 100081, Peoples R China
4.Peking Univ, Cent Lab, Hosp Stomatol, Beijing 100081, Peoples R China
5.Peking Univ, Lab Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
6.Peking Univ, Lab Oral & Maxillofacial Surg, Hosp Stomatol, Beijing 100081, Peoples R China
7.Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
8.Peking Univ, Dept Oral & Maxillofacial Surg, Hosp Stomatol, Beijing 100081, Peoples R China
9.Natl Univ Singapore, Fac Dent Res Labs, Singapore 119083, Singapore
推荐引用方式
GB/T 7714
Peng, Hui,Zhang, Xuehui,Wei, Yan,et al. Cytotoxicity of Silver Nanoparticles in Human Embryonic Stem Cell-Derived Fibroblasts and an L-929 Cell Line[J]. JOURNAL OF NANOMATERIALS,2012.
APA Peng, Hui.,Zhang, Xuehui.,Wei, Yan.,Liu, Wentao.,Li, Shenglin.,...&Deng, Xuliang.(2012).Cytotoxicity of Silver Nanoparticles in Human Embryonic Stem Cell-Derived Fibroblasts and an L-929 Cell Line.JOURNAL OF NANOMATERIALS.
MLA Peng, Hui,et al."Cytotoxicity of Silver Nanoparticles in Human Embryonic Stem Cell-Derived Fibroblasts and an L-929 Cell Line".JOURNAL OF NANOMATERIALS (2012).
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