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学科主题: 药学
题名:
Synthesis and analgesic effects of kyotorphin - steroid linkers
作者: Wang, C; Zhao, M; Yang, J; Peng, SQ
关键词: hydrocortisone ; estrone ; kyotorphin ; linker ; analgesia
刊名: STEROIDS
发表日期: 2001-11-01
卷: 66, 期:11, 页:811-815
收录类别: IC ; SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: DERIVATIVES
英文摘要:

Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher than that of KTP and the mixture of KTP and hydrocortisone or estrone in the CNS and/or the periphery administration. (C) 2001 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000171679800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62270
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, C,Zhao, M,Yang, J,et al. Synthesis and analgesic effects of kyotorphin - steroid linkers[J]. STEROIDS,2001,66(11):811-815.
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