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Strategies on the Quality Control and DMPK Studies of Traditional Chinese Medicine
Min, Ye; Dean, Guo
关键词traditional Chinese medicines quality control DMPK studies fingerprinting
刊名PROGRESS IN CHEMISTRY
2009
21期:1页:100-104
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION MASS-SPECTROMETRY ; CYTOTOXIC BUFADIENOLIDES ; MICROBIAL HYDROXYLATION ; ALTERNARIA-ALTERNATA ; CATHARANTHUS-ROSEUS ; PHENOLIC-COMPOUNDS ; CINOBUFAGIN ; BIOTRANSFORMATION ; CHANSU
英文摘要

Quality control is critically important for the safety and efficacy of traditional Chinese medicine. DMPK (drug metabolism and pharmacokinetic) studies facilitate the clarification of tire mechanism of action of traditional Chinese medicine. In this paper, we discuss the current barriers in the quality control and DMPK studies of traditional Chinese medicine by using our studies on toad venom (Chan-Su) as example. It is concluded that the combination of full assignments of the chemical finger-print and the simultaneous quantitation of multiple compounds is a feasible way for the comprehensive quality control of traditional Chinese medicines. Liquid chromatography/mass spectrometry (LC/MS) will play an important role in chemistry and DMPK studies of traditional Chinese medicine. The chemical fingerprints of traditional Chinese medicines should be correlated with their pharmacological activities so as to establish a reasonable traditional Chinese medicine quality evaluation system. Structural modification could be valuable for natural product-based drug discovery.

语种中文
WOS记录号WOS:000262685700011
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62275
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Min, Ye,Dean, Guo. Strategies on the Quality Control and DMPK Studies of Traditional Chinese Medicine[J]. PROGRESS IN CHEMISTRY,2009,21(1):100-104.
APA Min, Ye,&Dean, Guo.(2009).Strategies on the Quality Control and DMPK Studies of Traditional Chinese Medicine.PROGRESS IN CHEMISTRY,21(1),100-104.
MLA Min, Ye,et al."Strategies on the Quality Control and DMPK Studies of Traditional Chinese Medicine".PROGRESS IN CHEMISTRY 21.1(2009):100-104.
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