北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Strategies on the Quality Control and DMPK Studies of Traditional Chinese Medicine
作者: Min, Ye; Dean, Guo
关键词: traditional Chinese medicines ; quality control ; DMPK studies ; fingerprinting
刊名: PROGRESS IN CHEMISTRY
发表日期: 2009
卷: 21, 期:1, 页:100-104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION MASS-SPECTROMETRY ; CYTOTOXIC BUFADIENOLIDES ; MICROBIAL HYDROXYLATION ; ALTERNARIA-ALTERNATA ; CATHARANTHUS-ROSEUS ; PHENOLIC-COMPOUNDS ; CINOBUFAGIN ; BIOTRANSFORMATION ; CHANSU
英文摘要:

Quality control is critically important for the safety and efficacy of traditional Chinese medicine. DMPK (drug metabolism and pharmacokinetic) studies facilitate the clarification of tire mechanism of action of traditional Chinese medicine. In this paper, we discuss the current barriers in the quality control and DMPK studies of traditional Chinese medicine by using our studies on toad venom (Chan-Su) as example. It is concluded that the combination of full assignments of the chemical finger-print and the simultaneous quantitation of multiple compounds is a feasible way for the comprehensive quality control of traditional Chinese medicines. Liquid chromatography/mass spectrometry (LC/MS) will play an important role in chemistry and DMPK studies of traditional Chinese medicine. The chemical fingerprints of traditional Chinese medicines should be correlated with their pharmacological activities so as to establish a reasonable traditional Chinese medicine quality evaluation system. Structural modification could be valuable for natural product-based drug discovery.

语种: 中文
WOS记录号: WOS:000262685700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62275
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Min, Ye,Dean, Guo. Strategies on the Quality Control and DMPK Studies of Traditional Chinese Medicine[J]. PROGRESS IN CHEMISTRY,2009,21(1):100-104.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Min, Ye]'s Articles
[Dean, Guo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Min, Ye]‘s Articles
[Dean, Guo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace