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学科主题: 临床医学
题名:
Effect of passive cigarette smoking on colonic alpha 7-nicotinic acetylcholine receptors in TNBS-induced colitis in rats
作者: Sun, Ya P.1; Wang, Hua H.1; He, Qun2; Cho, Chi H.3
关键词: passive cigarette smoking ; experimental colitis ; 2,4,6-trinitrobenzenesulfonic acid ; alpha 7-nicotinic acetylcholine receptor
刊名: DIGESTION
发表日期: 2007
DOI: 10.1159/000112643
卷: 76, 期:3-4, 页:181-187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INFLAMMATORY-BOWEL-DISEASE ; AGGRAVATES EXPERIMENTAL COLITIS ; ACTIVE ULCERATIVE-COLITIS ; TUMOR-NECROSIS-FACTOR ; TRANSDERMAL NICOTINE ; CLINICAL-COURSE ; BINDING SITES ; CELL-LINE ; TNF-ALPHA ; EXPRESSION
英文摘要:

Background and Aims: Cigarette smoking affects colonic inflammation, but the exact mechanism by which it does so is unclear. The aim of this study was to investigate the underlying mechanism by examining the effect of cigarette smoking on 2,4,6-trinitrobenzenesulfonic acid ( TNBS)-induced colitis in rats. Method: Experimental colitis was induced by administrating TNBS enema in Sprague-Dawley rats. The effect of cigarette smoking was assessed by measuring the colonic edema, mucosal lesion area, histopathological score, mucosal myeloperoxidase ( MPO) activity and tumor necrosis factor-alpha ( TNF-alpha). The expression of alpha 7-nicotinic acetylcholine receptor (alpha 7nAChR) was examined after cigarette smoking to identify whether the alpha 7nAChR is involved in inflammation. Results: TNBS induced severe colitis as evidenced by increased colonic edema, mucosal lesion area, histopathological score, MPO activity, and TNF-alpha level. Inflammation was aggravated by cigarette smoke exposure. Colonic tissue expressed alpha 7nAChR ( 0.41 +/- 0.11), and TNBS up-regulated the receptor expression ( 0.46 +/- 0.11), but the difference was not significant ( p 1 0.05). Cigarette smoking with 2 and 4% respectively significantly increased the expression of alpha 7nAChR ( 0.55 +/- 0.05 and 0.64 +/- 0.08) ( p < 0.05). Conclusions: The up-regulated expression of alpha 7nAChR after exposure to cigarette smoking indicates that alpha 7nAChR in colonic tissue may be involved in cigarette smoking damage in TNBS-induced colitis in rats. Copyright (C) 2007 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000253013600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62279
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Dept Gastroenterol, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Lab Urol Pathol, Beijing 100034, Peoples R China
3.Univ Hong Kong, Fac Med, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Sun, Ya P.,Wang, Hua H.,He, Qun,et al. Effect of passive cigarette smoking on colonic alpha 7-nicotinic acetylcholine receptors in TNBS-induced colitis in rats[J]. DIGESTION,2007,76(3-4):181-187.
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