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学科主题临床医学
Effect of passive cigarette smoking on colonic alpha 7-nicotinic acetylcholine receptors in TNBS-induced colitis in rats
Sun, Ya P.1; Wang, Hua H.1; He, Qun2; Cho, Chi H.3
关键词passive cigarette smoking experimental colitis 2,4,6-trinitrobenzenesulfonic acid alpha 7-nicotinic acetylcholine receptor
刊名DIGESTION
2007
DOI10.1159/000112643
76期:3-4页:181-187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]INFLAMMATORY-BOWEL-DISEASE ; AGGRAVATES EXPERIMENTAL COLITIS ; ACTIVE ULCERATIVE-COLITIS ; TUMOR-NECROSIS-FACTOR ; TRANSDERMAL NICOTINE ; CLINICAL-COURSE ; BINDING SITES ; CELL-LINE ; TNF-ALPHA ; EXPRESSION
英文摘要

Background and Aims: Cigarette smoking affects colonic inflammation, but the exact mechanism by which it does so is unclear. The aim of this study was to investigate the underlying mechanism by examining the effect of cigarette smoking on 2,4,6-trinitrobenzenesulfonic acid ( TNBS)-induced colitis in rats. Method: Experimental colitis was induced by administrating TNBS enema in Sprague-Dawley rats. The effect of cigarette smoking was assessed by measuring the colonic edema, mucosal lesion area, histopathological score, mucosal myeloperoxidase ( MPO) activity and tumor necrosis factor-alpha ( TNF-alpha). The expression of alpha 7-nicotinic acetylcholine receptor (alpha 7nAChR) was examined after cigarette smoking to identify whether the alpha 7nAChR is involved in inflammation. Results: TNBS induced severe colitis as evidenced by increased colonic edema, mucosal lesion area, histopathological score, MPO activity, and TNF-alpha level. Inflammation was aggravated by cigarette smoke exposure. Colonic tissue expressed alpha 7nAChR ( 0.41 +/- 0.11), and TNBS up-regulated the receptor expression ( 0.46 +/- 0.11), but the difference was not significant ( p 1 0.05). Cigarette smoking with 2 and 4% respectively significantly increased the expression of alpha 7nAChR ( 0.55 +/- 0.05 and 0.64 +/- 0.08) ( p < 0.05). Conclusions: The up-regulated expression of alpha 7nAChR after exposure to cigarette smoking indicates that alpha 7nAChR in colonic tissue may be involved in cigarette smoking damage in TNBS-induced colitis in rats. Copyright (C) 2007 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000253013600003
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62279
专题北京大学第一临床医学院_消化科
北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, First Hosp, Dept Gastroenterol, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Lab Urol Pathol, Beijing 100034, Peoples R China
3.Univ Hong Kong, Fac Med, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Sun, Ya P.,Wang, Hua H.,He, Qun,et al. Effect of passive cigarette smoking on colonic alpha 7-nicotinic acetylcholine receptors in TNBS-induced colitis in rats[J]. DIGESTION,2007,76(3-4):181-187.
APA Sun, Ya P.,Wang, Hua H.,He, Qun,&Cho, Chi H..(2007).Effect of passive cigarette smoking on colonic alpha 7-nicotinic acetylcholine receptors in TNBS-induced colitis in rats.DIGESTION,76(3-4),181-187.
MLA Sun, Ya P.,et al."Effect of passive cigarette smoking on colonic alpha 7-nicotinic acetylcholine receptors in TNBS-induced colitis in rats".DIGESTION 76.3-4(2007):181-187.
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