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学科主题: 临床医学
题名:
Surgical treatment of complex malignant anterior mediastinal tumors invading the superior vena cava
作者: Chen, KN; Xu, SF; Gu, ZD; Zhang, WM; Pan, H; Su, WZ; Li, JY; Xu, GW
刊名: WORLD JOURNAL OF SURGERY
发表日期: 2006-02-01
DOI: 10.1007/s00268-005-0009-x
卷: 30, 期:2, 页:162-170
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: INVASIVE THYMOMA ; DIAGNOSIS
英文摘要:

Determining the appropriate surgery-based treatment for complicated anterior mediastinal malignancies (CAMM), especially those invading the superior vena cava (SVC) and its branches, remains a challenge for general thoracic surgeons. In this report, we summarize our experience and lessons regarding this issue in order to discuss a reasonable strategy for diagnosis and treatment of CAMM. Between January 2001 and April 2003, 15 patients with CAMM invading the SVC and/or its branches with or without invasion of other neighboring organs were surgically treated in our institution by a single surgeon team. We collected clinical data from the medical charts and from surgeons′ specific notes for complicated cases, and performed a comprehensive analysis. There were 9 patients with malignant thymoma. Thymic carcinoma, teratoma, embryonal carcinoma, Hodgkin′s lymphoma, non-Hodgkin′s lymphoma, and mixed teratoma with thymoma were diagnosed in 1 patient each. All procedures were performed via median sternotomy. Some angioplasty techniques were successfully used to resect and reconstruct the SVC. Ten of the 15 patients also underwent pulmonary resection due to involvement of pulmonary parenchyma. Four of the patients underwent perioperative chemotherapy. There were no perioperative deaths. Two patients suffered prolonged ventilation after surgery, and there were no other severe complications related to surgery. One patient died 10 months after surgery. The remaining 14 patients were still living and their progress is still monitored. As of August 2004, the median follow-up duration for all patients was 35 months, and the disease-free survival duration was 10-43 months. CAMM can be safely and completely resected via a median sternotomy, even if it has invaded other mediastinal structures. CAMM should be pathologically identified before initial treatment. A good outcome for patients with CAMM is possible if a suitable strategy combining accurate diagnosis and appropriate treatment, especially surgical resection, is established.

语种: 英语
WOS记录号: WOS:000234928300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62285
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Thorac Surg, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100036, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Gen Surg, Beijing 100036, Peoples R China
4.Beijing TB & Thorac Tumor Res Inst, Dept Thorac Surg, Beijing 101149, Peoples R China

Recommended Citation:
Chen, KN,Xu, SF,Gu, ZD,et al. Surgical treatment of complex malignant anterior mediastinal tumors invading the superior vena cava[J]. WORLD JOURNAL OF SURGERY,2006,30(2):162-170.
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