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Submacular DL-alpha-Aminoadipic Acid Eradicates Primate Photoreceptors but Does Not Affect Luteal Pigment or the Retinal Vasculature
Shen, Weiyong1; Zhang, Jun2; Chung, Sook Hyun1; Hu, Yuntao2; Ma, Zhizhong2; Gillies, Mark C.1
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2011
DOI10.1167/iovs.10-6033
52期:1页:119-127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]IDIOPATHIC MACULAR TELANGIECTASIA ; OPTICAL COHERENCE TOMOGRAPHY ; CYSTINE-GLUTAMATE ANTIPORTER ; MULLER GLIAL-CELL ; PERIFOVEAL TELANGIECTASIA ; INTRAVITREAL BEVACIZUMAB ; BINDING PROTEIN ; FOVEA CENTRALIS ; TRANSGENIC MICE ; IN-VIVO
英文摘要

PURPOSE. Macular telangiectasia type 2 (MT2) is a condition of uncertain etiology characterized by retinal vascular abnormalities, depletion of luteal pigment, and photoreceptor loss. To model this condition, the authors recently used a purportedly glial-selective toxin, DL-alpha-aminoadipic acid (DL-alpha-AAA), to test the effect of Muller cell disruption on the blood-retinal barrier in rats. In this study, they investigated macular changes after subretinal injection of DL-alpha-AAA in monkeys.

METHODS. Various doses of DL-alpha-AAA were injected beneath the macula in eight monkey eyes. Eyes were examined by multifocal electroretinography (mfERG), optical coherence tomography (OCT), fundus autofluorescence, color photography, and fluorescein angiography. Five months after injection, eyes were examined by histology and immunohistochemistry for changes in photoreceptors and the retinal glia. In vitro studies evaluated the effect of DL-alpha-AAA on 661W cone photoreceptor viability.

RESULTS. Subretinal injection of DL-alpha-AAA resulted in virtually complete ablation of photoreceptors in the injected area, as shown by OCT and histology, and severely impaired mfERG responses. Muller cells, albeit activated, survived the injury. Macular pigment remained unchanged in the central fovea. Subretinal injection of DL-alpha-AAA did not induce vascular leakage, though it increased the fundus autofluorescence. DL-alpha-AAA had a dose-dependent toxic effect on 661W photoreceptors.

CONCLUSIONS. Submacular injection of DL-alpha-AAA induced severe damage to photoreceptors but failed to eliminate Muller cells in monkeys. Central macular pigment persisted despite loss of photoreceptors, and the retinal vasculature was unaffected. These observations may have significance in studying the roles of different cellular components in the pathogenesis of MT2. (Invest Ophthalmol Vis Sci. 2011; 52: 119-127) DOI: 10.1167/iovs.10-6033

语种英语
WOS记录号WOS:000285925000017
资助机构Lowy Medical Research Institute, Australia ; University of Sydney
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62286
专题北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Ctr Eye, Hosp 3, Beijing 100871, Peoples R China
2.Univ Sydney, Retinal Therapeut Res Grp, Save Sight Inst, Sydney, NSW 2000, Australia
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Shen, Weiyong,Zhang, Jun,Chung, Sook Hyun,et al. Submacular DL-alpha-Aminoadipic Acid Eradicates Primate Photoreceptors but Does Not Affect Luteal Pigment or the Retinal Vasculature[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2011,52(1):119-127.
APA Shen, Weiyong,Zhang, Jun,Chung, Sook Hyun,Hu, Yuntao,Ma, Zhizhong,&Gillies, Mark C..(2011).Submacular DL-alpha-Aminoadipic Acid Eradicates Primate Photoreceptors but Does Not Affect Luteal Pigment or the Retinal Vasculature.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,52(1),119-127.
MLA Shen, Weiyong,et al."Submacular DL-alpha-Aminoadipic Acid Eradicates Primate Photoreceptors but Does Not Affect Luteal Pigment or the Retinal Vasculature".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52.1(2011):119-127.
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