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学科主题: 药学
题名:
Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease
作者: Sun, QZ; Chen, DF; Ding, PL; Ma, CM; Kakuda, H; Nakamura, N; Hattori, M
关键词: longipedunin ; Kadsura longipedunculata ; HIV-1 protease ; lignan ; X-ray crystal structure
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2006
卷: 54, 期:1, 页:129-132
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: DIBENZOCYCLOOCTADIENE LIGNANS ; CONSTITUENTS ; CHINENSIS
英文摘要:

Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedtunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 mu M, respectively.

语种: 英语
WOS记录号: WOS:000234790900029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62288
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Toyama Med & Pharmaceut Univ, Chem Lab, Toyama 9300194, Japan
2.Toyama Med & Pharmaceut Univ, Inst Nat Med, Dept Metab Engn, Toyama 9300194, Japan
3.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

Recommended Citation:
Sun, QZ,Chen, DF,Ding, PL,et al. Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2006,54(1):129-132.
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