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学科主题: 临床医学
题名:
De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients
作者: Fan, Xiao-Hong1; Geng, Jian-Zhang2; Wang, Li-Fen1; Zheng, Ying-Ying1; Lu, Hai-Ying1; Li, Jing2; Xu, Xiao-Yuan1
关键词: Hepatitis B ; Chronic ; Cirrhosis ; Decompensated ; De novo combination ; Lamivudine ; Adefovir dipivoxil
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2011-11-21
DOI: 10.3748/wjg.v17.i43.4804
卷: 17, 期:43, 页:4804-4809
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: LIVER-DISEASE ; E-ANTIGEN ; VIRUS ; CIRRHOSIS ; RESISTANT ; SURVIVAL ; SEROCONVERSION ; CHILD ; MELD ; HBE
英文摘要:

AIM: To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B (CHB) patients with decompensated cirrhosis.

METHODS: Thirty HBeAg positive CHB patients with decompensated cirrhosis were enrolled in the study. All of the patients were given 48 wk combination therapy with lamivudine (LAM) and adefovir dipivoxil (ADV). Briefly, 10 patients were given the de novo combination therapy with LAM and ADV, whereas the other 20 patients received ADV in addition to LAM after hepatitis B virus (HBV) genetic mutation.

RESULTS: Serum alanine aminotransferase and total bilirubin were both improved in the two groups at 4, 12, 24 and 48 wk after treatment. Serum albumin was also improved at 24 and 48 wk after combination therapy in both groups. The serum HBV DNA level was still detectable in every patient in the two groups at 4 and 12 wk after combination treatment. However, in the de novo combination group, serum HBV DNA levels in 4 (40%) and 9 (90%) patients was decreased to below 1x10(3) copies/mL at 24 and 48 wk after the combination treatment, respectively. In parallel, serum HBV DNA levels in 2 (20%) and 8 (40%) patients in the add-on combination group became undetectable at 24 and 48 wk after combination treatment, respectively. Furthermore, 6 (60%) patients in the de novo combination group achieved HBeAg seroconversion after 48 wk treatment, whereas only 4 (20%) patients in the add-on combination group achieved seroconversion. Child-Pugh score of patients in the de novo combination group was better than that of patients in the add-on combination group after 48 wk treatment. Moreover, patients in the de novo combination group had a significantly decreased serum creatinine level and elevated red blood cell counts.

CONCLUSION: De novo combination therapy with LAM and ADV was better than add-on combination therapy in terms of Child-Pugh score, virus inhibition and renal function. (C) 2011 Baishideng. All rights reserved.

语种: 英语
所属项目编号: GHF2010205
项目资助者: Chinese foundation for hepatitis prevention and control
WOS记录号: WOS:000298004000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62291
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Shijiazhuang Fifth Hosp, Dept Infect Dis, Shijiazhuang 050021, Hebei Province, Peoples R China

Recommended Citation:
Fan, Xiao-Hong,Geng, Jian-Zhang,Wang, Li-Fen,et al. De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(43):4804-4809.
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