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Acute effect of ambient ozone on heart rate variability in healthy elderly subjects
Jia, Xiaofeng; Song, Xiaoming; Shima, Masayuki2; Tamura, Kenji3; Deng, Furong; Guo, Xinbiao1
关键词ozone fine particulate matter nitrogen oxides heart rate variability healthy elderly subject
刊名JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
2011-09-01
DOI10.1038/jes.2011.18
21期:5页:541-547
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
关键词[WOS]AIR-POLLUTION ; MYOCARDIAL-INFARCTION ; DAILY MORTALITY ; MEXICO-CITY ; DISEASE ; RISK ; ASSOCIATION ; POPULATION ; EXPOSURE ; ADULTS
英文摘要

Acute ambient ozone (O(3)) exposure is associated with the increased mortality and morbidity of cardiovascular diseases. The dysfunction of cardiac autonomic nervous system (ANS), indicated by the disturbed heart rate variability (HRV), may be the most important underlying mechanism. Previous studies reported the heterogeneous associations between O(3) within several hours′ exposure and HRV on general elderly subjects, in which poor surrogate of exposure evaluation and different health status of the subjects may be responsible for the heterogeneous associations. No studies were found focusing on the O(3)-mediated HRV effects within several minutes′ exposure on healthy older subjects until recently. We measured the real-time 5-min ambient O(3) concentration and HRV frequency indices in 20 healthy elderly subjects in two surveys, with the 1st and 2nd survey in summer and winter, respectively. Mixed-linear model was used to evaluate the associations between the ambient 5-min average O(3) and concurrent 5-min HRV frequency indices measured during the outdoor period. After adjusting the co-pollutants (ambient PM(2.5) and nitrogen oxides concentrations) and subject characteristics, high frequency (HF) changed -4.87% (95% CI -8.62 to -0.97%) per 10 ppb increment of O(3), whereas decreased low frequency (LF) and increased LFHFR were found to be marginally associated with the elevated O(3) (P values were 0.092 and 0.069). We concluded that the ambient O(3) exert transient decrease effects on HRV, which may induce acute cardiac events. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 541-547; doi: 10.1038/jes.2011.18; published online 27 April 2011

语种英语
WOS记录号WOS:000294158000011
项目编号2006BAI19B06 ; 81072267
资助机构National Key Technologies R&amp ; D Program of China ; National Natural Science Foundation of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62293
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
2.Hyogo Coll Med, Nishinomiya, Hyogo 6638501, Japan
3.Natl Inst Environm Studies, Tsukuba, Ibaraki, Japan
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GB/T 7714
Jia, Xiaofeng,Song, Xiaoming,Shima, Masayuki,et al. Acute effect of ambient ozone on heart rate variability in healthy elderly subjects[J]. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY,2011,21(5):541-547.
APA Jia, Xiaofeng,Song, Xiaoming,Shima, Masayuki,Tamura, Kenji,Deng, Furong,&Guo, Xinbiao.(2011).Acute effect of ambient ozone on heart rate variability in healthy elderly subjects.JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY,21(5),541-547.
MLA Jia, Xiaofeng,et al."Acute effect of ambient ozone on heart rate variability in healthy elderly subjects".JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 21.5(2011):541-547.
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