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学科主题: 公共卫生
题名:
Acute effect of ambient ozone on heart rate variability in healthy elderly subjects
作者: Jia, Xiaofeng; Song, Xiaoming; Shima, Masayuki2; Tamura, Kenji3; Deng, Furong; Guo, Xinbiao1
关键词: ozone ; fine particulate matter ; nitrogen oxides ; heart rate variability ; healthy elderly subject
刊名: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
发表日期: 2011-09-01
DOI: 10.1038/jes.2011.18
卷: 21, 期:5, 页:541-547
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
关键词[WOS]: AIR-POLLUTION ; MYOCARDIAL-INFARCTION ; DAILY MORTALITY ; MEXICO-CITY ; DISEASE ; RISK ; ASSOCIATION ; POPULATION ; EXPOSURE ; ADULTS
英文摘要:

Acute ambient ozone (O(3)) exposure is associated with the increased mortality and morbidity of cardiovascular diseases. The dysfunction of cardiac autonomic nervous system (ANS), indicated by the disturbed heart rate variability (HRV), may be the most important underlying mechanism. Previous studies reported the heterogeneous associations between O(3) within several hours′ exposure and HRV on general elderly subjects, in which poor surrogate of exposure evaluation and different health status of the subjects may be responsible for the heterogeneous associations. No studies were found focusing on the O(3)-mediated HRV effects within several minutes′ exposure on healthy older subjects until recently. We measured the real-time 5-min ambient O(3) concentration and HRV frequency indices in 20 healthy elderly subjects in two surveys, with the 1st and 2nd survey in summer and winter, respectively. Mixed-linear model was used to evaluate the associations between the ambient 5-min average O(3) and concurrent 5-min HRV frequency indices measured during the outdoor period. After adjusting the co-pollutants (ambient PM(2.5) and nitrogen oxides concentrations) and subject characteristics, high frequency (HF) changed -4.87% (95% CI -8.62 to -0.97%) per 10 ppb increment of O(3), whereas decreased low frequency (LF) and increased LFHFR were found to be marginally associated with the elevated O(3) (P values were 0.092 and 0.069). We concluded that the ambient O(3) exert transient decrease effects on HRV, which may induce acute cardiac events. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 541-547; doi: 10.1038/jes.2011.18; published online 27 April 2011

语种: 英语
所属项目编号: 2006BAI19B06 ; 81072267
项目资助者: National Key Technologies R&amp ; D Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000294158000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62293
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
2.Hyogo Coll Med, Nishinomiya, Hyogo 6638501, Japan
3.Natl Inst Environm Studies, Tsukuba, Ibaraki, Japan

Recommended Citation:
Jia, Xiaofeng,Song, Xiaoming,Shima, Masayuki,et al. Acute effect of ambient ozone on heart rate variability in healthy elderly subjects[J]. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY,2011,21(5):541-547.
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