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Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen
Zheng, Xiu-Jing1,2; Yang, Fan1,2; Zheng, Mingwei1,2; Huo, Chang-Xin1,2; Zhang, Ye3; Ye, Xin-Shan1,2
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
2015
DOI10.1039/c5ob00405e
13期:22页:6399-6406
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]MUC1 GLYCOPEPTIDE ANTIGENS ; T-CELL EPITOPE ; CONJUGATE VACCINE ; SYNTHETIC VACCINES ; GANGLIOSIDE GM3 ; POLYSIALIC ACID ; MELANOMA-CELLS ; TUMOR-CELLS ; CHEMOENZYMATIC SYNTHESIS ; LIMPET HEMOCYANIN
英文摘要

Tumor cells often display aberrant levels and patterns of cell surface glycosylation, which provides a potential opportunity to develop carbohydrate-based anticancer vaccines for cancer immunotherapy. However, one of the most addressed challenges in this field is the low efficiency of the carbohydrate vaccination due to poor immunogenicity of carbohydrate antigens. In this article, a number of structure-modified GM3 antigen analogues were designed and chemically synthesized. The modified GM3 antigens were conjugated to protein carriers for vaccination. The vaccination results on mice show that the modification on the GM3 antigen could improve the efficiency of the vaccination, and in particular, two glycoconjugates (3-KLH and 8-KLH) elicited higher titers of anti-GM3 antibodies than the unmodified GM3-protein conjugate (2-KLH) did.

语种英语
WOS记录号WOS:000355489600030
项目编号2012CB822100 ; 2013CB910700 ; 2012ZX09103301-048 ; 21232002 ; 81172916 ; BMU20140476
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Center for Molecular and Translational Medicine
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62295
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_药物化学系
作者单位1.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Mol & Translat Med, Beijing 100191, Peoples R China
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GB/T 7714
Zheng, Xiu-Jing,Yang, Fan,Zheng, Mingwei,et al. Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(22):6399-6406.
APA Zheng, Xiu-Jing,Yang, Fan,Zheng, Mingwei,Huo, Chang-Xin,Zhang, Ye,&Ye, Xin-Shan.(2015).Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen.ORGANIC & BIOMOLECULAR CHEMISTRY,13(22),6399-6406.
MLA Zheng, Xiu-Jing,et al."Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen".ORGANIC & BIOMOLECULAR CHEMISTRY 13.22(2015):6399-6406.
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