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学科主题: 药学
题名:
Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen
作者: Zheng, Xiu-Jing1,2; Yang, Fan1,2; Zheng, Mingwei1,2; Huo, Chang-Xin1,2; Zhang, Ye3; Ye, Xin-Shan1,2
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2015
DOI: 10.1039/c5ob00405e
卷: 13, 期:22, 页:6399-6406
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: MUC1 GLYCOPEPTIDE ANTIGENS ; T-CELL EPITOPE ; CONJUGATE VACCINE ; SYNTHETIC VACCINES ; GANGLIOSIDE GM3 ; POLYSIALIC ACID ; MELANOMA-CELLS ; TUMOR-CELLS ; CHEMOENZYMATIC SYNTHESIS ; LIMPET HEMOCYANIN
英文摘要:

Tumor cells often display aberrant levels and patterns of cell surface glycosylation, which provides a potential opportunity to develop carbohydrate-based anticancer vaccines for cancer immunotherapy. However, one of the most addressed challenges in this field is the low efficiency of the carbohydrate vaccination due to poor immunogenicity of carbohydrate antigens. In this article, a number of structure-modified GM3 antigen analogues were designed and chemically synthesized. The modified GM3 antigens were conjugated to protein carriers for vaccination. The vaccination results on mice show that the modification on the GM3 antigen could improve the efficiency of the vaccination, and in particular, two glycoconjugates (3-KLH and 8-KLH) elicited higher titers of anti-GM3 antibodies than the unmodified GM3-protein conjugate (2-KLH) did.

语种: 英语
所属项目编号: 2012CB822100 ; 2013CB910700 ; 2012ZX09103301-048 ; 21232002 ; 81172916 ; BMU20140476
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Center for Molecular and Translational Medicine
WOS记录号: WOS:000355489600030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62295
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Mol & Translat Med, Beijing 100191, Peoples R China

Recommended Citation:
Zheng, Xiu-Jing,Yang, Fan,Zheng, Mingwei,et al. Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(22):6399-6406.
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