IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells
Liu, XY; Sun, Y; Guo, JP; Ma, H; Li, JY; Dong, B; Jin, GL; Zhang, JZ; Wu, J; Meng, L; Shou, CC
关键词hiwi expression gastric cancer proliferation
刊名INTERNATIONAL JOURNAL OF CANCER
2006-04-15
DOI10.1002/ijc.21575
118期:8页:1922-1929
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]STEM-CELL ; PIWI ; FAMILY
英文摘要

Stem cell genetics research may be critical to our understanding of carcinogenesis, as both stem cells and cancer cells possess the ability to self-renew. Recent discoveries have indicated that the piwi family of genes plays an essential role in stem cell self-renewal in diverse organisms. The hiwi gene, the human homolog of the piwi family, participates in germ cell proliferation and its overexpression may cause the development of germ cell malignancy, but its expression and function in epithelial solid cancers have not been explored. In the present study, we investigated whether there was an association between hiwi expression and human gastric cancer and its potential mechanism. RT-PCR findings demonstrated that hiwi was expressed in different gastric cancer cell lines. To identify the HIWI protein in gastric cancer, we developed a specific monoclonal antibody against HIWI and immunohistochemistry was performed on various gastric tissues. We found that the expression ratio of hiwi in normal gastric tissues, atrophic gastritis, intestinal metaplasia and gastric cancers was 10% (5/50), 36% (18/50), 36% (18/50) and 76% (38/50), respectively, which was consistent with precancerous development. Notably, the expression pattern of hiwi in gastric cancer tissues was similar to that of Ki67, which was used as a marker of proliferation. Moreover, the suppression of hiwi by antisense or RNAi inhibited the growth of gastric cancer cells and induced cell cycle arrest in G(2)/M phase. These results suggest that hiwi may be involved in the development of gastric cancer and is a potential target for cancer therapy. (c) 2005 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000236397200010
引用统计
被引频次:110[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62298
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Inc Canc Res, Dept Biochem & Mol Biol, Beijing 100034, Peoples R China
2.Peking Univ, Dept Pathol, Sch Oncol, Beijing Canc Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, XY,Sun, Y,Guo, JP,et al. Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells[J]. INTERNATIONAL JOURNAL OF CANCER,2006,118(8):1922-1929.
APA Liu, XY.,Sun, Y.,Guo, JP.,Ma, H.,Li, JY.,...&Shou, CC.(2006).Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells.INTERNATIONAL JOURNAL OF CANCER,118(8),1922-1929.
MLA Liu, XY,et al."Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells".INTERNATIONAL JOURNAL OF CANCER 118.8(2006):1922-1929.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, XY]的文章
[Sun, Y]的文章
[Guo, JP]的文章
百度学术
百度学术中相似的文章
[Liu, XY]的文章
[Sun, Y]的文章
[Guo, JP]的文章
必应学术
必应学术中相似的文章
[Liu, XY]的文章
[Sun, Y]的文章
[Guo, JP]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。