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学科主题: 药物依赖
题名:
Conditioned drug reward enhances subsequent spatial learning and memory in rats
作者: Zhai, Hai-feng; Zhang, Zhang-Yin; Zhao, Mei; Qiu, Yi; Ghitza, Udi E.; Lu, Lin
关键词: morphine ; cocaine ; sucrose ; conditioned reward ; conditioned aversion ; spatial learning
刊名: PSYCHOPHARMACOLOGY
发表日期: 2007-12-01
DOI: 10.1007/s00213-007-0893-x
卷: 195, 期:2, 页:193-201
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: INTRACRANIAL SELF-STIMULATION ; VENTRAL TEGMENTAL AREA ; PLACE-PREFERENCE ; D-AMPHETAMINE ; OPIATE WITHDRAWAL ; INTRAACCUMBENS AMPHETAMINE ; INCENTIVE-SENSITIZATION ; REPEATED PRETREATMENT ; HIPPOCAMPAL-LESIONS ; NUCLEUS-ACCUMBENS
英文摘要:

Rationale Chronic exposure to drugs of abuse alters neural processes that normally promote learning and memory. A context that is repeatedly paired with reinforcing drugs will acquire secondary reinforcing properties (conditioned reward). However, the effects of conditioned reward on spatial learning are unknown.

Objective Using the conditioned place preference procedure and Morris water maze task, we examined the role of conditioned reward or aversion in spatial learning.

Materials and methods Groups of rats acquired morphine (10 mg/kg), cocaine (10 mg/kg), or oral sucrose (15%) conditioned place preference (CPP). Another group of morphine-dependent rats acquired conditioned place aversion (CPA) to a context paired with precipitated opiate withdrawal induced by naloxone injections (1 mg/kg). To examine the role of conditioned reward or aversion in spatial learning, rats were then exposed to the previously morphine-, cocaine-, sucrose- or naloxone-paired context for 10 min before training of spatial learning in the Morris water maze.

Results Exposure to the morphine- or cocaine- paired but not the sucrose- or the naloxone-paired context decreased the latency to find the platform in the Morris water maze test.

Conclusions Our results provide the first evidence that conditioned drug reward promotes spatial learning. We speculate that this enhancement of spatial learning by the drug-paired context may promote contextual-cue-induced relapse to drug taking by facilitating exploratory drugseeking behaviors.

语种: 英语
WOS记录号: WOS:000250594200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62299
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA
3.Natl Inst Drug Abuse, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Zhai, Hai-feng,Zhang, Zhang-Yin,Zhao, Mei,et al. Conditioned drug reward enhances subsequent spatial learning and memory in rats[J]. PSYCHOPHARMACOLOGY,2007,195(2):193-201.
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