IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Remineralizing Efficacy of Fluorohydroxyapatite Gel on Artificial Dentinal Caries Lesion
Wang, Qianqian1; Liu, Shize2; Gao, Xuejun3; Wei, Yan1; Deng, Xuliang1,4; Chen, Haifeng2; Zhang, Xuehui1,5
刊名JOURNAL OF NANOMATERIALS
2015
DOI10.1155/2015/380326
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]MINERAL TRIOXIDE AGGREGATE ; CALCIUM-PHOSPHATE ; IN-VITRO ; CEMENT ; HYDROXIDE ; FLUORIDE ; GROWTH
英文摘要

The aim was to evaluate the remineralizing efficacy of fluorohydroxyapatite (FHA) gel on artificial dentinal caries lesion in vitro. Artificial carious lesions were made on occlusal cavities of teeth by exposing the dentin surface to a demineralizing solution. Each cavity was capped with a 3mm thick FHA gel for 4 weeks. After the FHA gel was removed, the surface morphology and structure of the dentin were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The dentin mineral density (DMD) was measured by micro-computed tomography (Micro-CT). A layer of dense and orderly hexagonal crystal structure, with average diameter of 1 mu m and thickness of 4 similar to 5 mu m, could be observed on dentin surface. These crystals exhibited elemental peaks for calcium, phosphorus, carbon, and oxygen and characteristic peaks of hydroxyapatite (HA) and fluorapatite (FA) via XRD and FT-IR. The DMD of dentin surface layer significantly increased after it was capped with FHA gel (P < 0.05). In the present study, the FHA gel could rapidly construct apatite on the artificial dentin caries surface and significantly increase the mineral density, which suggests that FHA gel might be a proper IPT material with remineralizing function.

语种英语
WOS记录号WOS:000363621400001
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62307
专题北京大学口腔医学院
北京大学第一临床医学院_超声诊断中心
北京大学口腔医学院_牙体牙髓科
北京大学口腔医学院_特诊科
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Peking Univ, Dept Geriatr Dent, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100081, Peoples R China
3.Peking Univ, Dept Cariol & Endodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
5.Peking Univ, Dept Dent Mat, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, Qianqian,Liu, Shize,Gao, Xuejun,et al. Remineralizing Efficacy of Fluorohydroxyapatite Gel on Artificial Dentinal Caries Lesion[J]. JOURNAL OF NANOMATERIALS,2015.
APA Wang, Qianqian.,Liu, Shize.,Gao, Xuejun.,Wei, Yan.,Deng, Xuliang.,...&Zhang, Xuehui.(2015).Remineralizing Efficacy of Fluorohydroxyapatite Gel on Artificial Dentinal Caries Lesion.JOURNAL OF NANOMATERIALS.
MLA Wang, Qianqian,et al."Remineralizing Efficacy of Fluorohydroxyapatite Gel on Artificial Dentinal Caries Lesion".JOURNAL OF NANOMATERIALS (2015).
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