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学科主题: 口腔医学
题名:
Remineralizing Efficacy of Fluorohydroxyapatite Gel on Artificial Dentinal Caries Lesion
作者: Wang, Qianqian1; Liu, Shize2; Gao, Xuejun3; Wei, Yan1; Deng, Xuliang1,4; Chen, Haifeng2; Zhang, Xuehui1,5
刊名: JOURNAL OF NANOMATERIALS
发表日期: 2015
DOI: 10.1155/2015/380326
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
关键词[WOS]: MINERAL TRIOXIDE AGGREGATE ; CALCIUM-PHOSPHATE ; IN-VITRO ; CEMENT ; HYDROXIDE ; FLUORIDE ; GROWTH
英文摘要:

The aim was to evaluate the remineralizing efficacy of fluorohydroxyapatite (FHA) gel on artificial dentinal caries lesion in vitro. Artificial carious lesions were made on occlusal cavities of teeth by exposing the dentin surface to a demineralizing solution. Each cavity was capped with a 3mm thick FHA gel for 4 weeks. After the FHA gel was removed, the surface morphology and structure of the dentin were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The dentin mineral density (DMD) was measured by micro-computed tomography (Micro-CT). A layer of dense and orderly hexagonal crystal structure, with average diameter of 1 mu m and thickness of 4 similar to 5 mu m, could be observed on dentin surface. These crystals exhibited elemental peaks for calcium, phosphorus, carbon, and oxygen and characteristic peaks of hydroxyapatite (HA) and fluorapatite (FA) via XRD and FT-IR. The DMD of dentin surface layer significantly increased after it was capped with FHA gel (P < 0.05). In the present study, the FHA gel could rapidly construct apatite on the artificial dentin caries surface and significantly increase the mineral density, which suggests that FHA gel might be a proper IPT material with remineralizing function.

语种: 英语
所属项目编号: 2012CB933900 ; 2011DFA32190 ; 2012BAI07B01 ; PKUSS20130103
项目资助者: National Basic Research Program of China ; Key International S&amp ; T Cooperation Projects ; Key Technologies R&amp ; D Program of China ; Science Foundation of Peking University School and Hospital of Stomatology
WOS记录号: WOS:000363621400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62307
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Geriatr Dent, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100081, Peoples R China
3.Peking Univ, Dept Cariol & Endodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
5.Peking Univ, Dept Dent Mat, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Wang, Qianqian,Liu, Shize,Gao, Xuejun,et al. Remineralizing Efficacy of Fluorohydroxyapatite Gel on Artificial Dentinal Caries Lesion[J]. JOURNAL OF NANOMATERIALS,2015.
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