IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA
Sun, Yu1,2; Li, Zhong-Wu1,2; Feng, Guo-Shuang1,3; Li, Ji-You1,2
关键词Intestinal metaplasia Subtype Follow-up Immunohistochemistry Gastric cancer
刊名CHINESE JOURNAL OF CANCER RESEARCH
2009-12-01
DOI10.1007/s11670-009-0272-8
21期:4页:272-277
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Beijing Municipal Science &amp ; Technology commission NOVA program ; National "863" High-Tech Res &amp ; Dev program of China ; Major State Basic Research Program of china ; Beijing Municipal Science &amp ; Technology commission NOVA program ; National "863" High-Tech Res &amp ; Dev program of China ; Major State Basic Research Program of china
研究领域[WOS]Oncology
关键词[WOS]HELICOBACTER-PYLORI INFECTION ; PRECANCEROUS LESIONS ; NATURAL-HISTORY ; CANCER ; MUCOSA ; CARCINOMA ; RISK ; STOMACH ; GENE ; CARCINOGENESIS
英文摘要

To investigate the correlation of typies of gastric intestinal metaplasia(IM), expression of p53, bcl-2 and the proliferating cell nuclear antigen(PCNA), with the lesion′s evolution.

A total of 80 patients with IM(53 male and 27 female, 35-64 years old) from an area with high-risk of gastric cancer(GC) in China were enrolled into this prospective study, including 28 cases of type I (complete), 25 cases of type II (incomplete), and 27 cases of type III (incomplete). Of the 80 cases, 62 cases including 19 cases of type I, 22 type II and 21 type III, were followed up for 5-14 years(49 cases for 14 years, 6 for 10 years, and 7 for 5 years). All of the 80 cases were studied immunohistochemically for the expression of p53, bcl-2 and PCNA.

The rate of p53-expressing cases was higher in type III (25.9%) than in type I (10.7%) and type II (12.0%), but without statistical significance(P=0.3070). The positive rate of bcl-2 was obviously lower in type I (21.4%) and type II (24.0%) than in type III (37.0%), but not statistically significant(P=0.4223). We observed difference in PCNA labelling index (LI) between type II and type III (P=0.0037), and the difference was particularly significant in type I as compared with type III (P < 0.0001). There was no statistical significance between type I and type II (P=0.0616).

Evolution into GC was detected in 0%, 4.5%, and 14.3% of type I, type II, and type III IM cases, respectively. Progression to dysplasia was detected in 31.6%, 18.2%, and 14.3% of type I, type II, and type III IM cases, respectively. Persistence of IM was documented in 31.6%, 45.5%, and 42.9% of type I, type II, and type III IM cases, respectively. Regression of IM was documented in 36.8%, 31.8%, and 28.6% of type I, type II, and type III IM cases, respectively.

In progressive, persistent and regressive groups, the positive rates of p53 were 17.6%, 16.0% and 15.0%, bcl-2 were 29.4%, 36.0% and 25.0%, and PCNA LIs were 24.953 +/- 14.477, 23.752 +/- 12.934 and 25.105 +/- 10.055, respectively. There were no significant differences between the groups.

The present follow-up study indicated that type III had a higher risk for development of cancer than type I or II. PCNA LI was significantly higher in type III than in type I and II, suggesting that cell proliferation in type III was more active. Our data also indicated that the expression of p53 and bcl-2 had no apparent association with the particular type and the expression of p53, bcl-2 and PCNA had no apparent correlation with evolution of IM. Further studies with a larger sample size are needed to verify present observation.

语种英语
所属项目编号2005B-44 ; 2006AA02A402 ; 2004CB518702
资助者Beijing Municipal Science &amp ; Technology commission NOVA program ; National "863" High-Tech Res &amp ; Dev program of China ; Major State Basic Research Program of china ; Beijing Municipal Science &amp ; Technology commission NOVA program ; National "863" High-Tech Res &amp ; Dev program of China ; Major State Basic Research Program of china
WOS记录号WOS:000272158500004
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62315
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
3.Chaoyang Dist Ctr Dis Control & Prevent, Beijing, Peoples R China
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GB/T 7714
Sun, Yu,Li, Zhong-Wu,Feng, Guo-Shuang,et al. Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(4):272-277.
APA Sun, Yu,Li, Zhong-Wu,Feng, Guo-Shuang,&Li, Ji-You.(2009).Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA.CHINESE JOURNAL OF CANCER RESEARCH,21(4),272-277.
MLA Sun, Yu,et al."Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA".CHINESE JOURNAL OF CANCER RESEARCH 21.4(2009):272-277.
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