|Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA|
|Sun, Yu1,2; Li, Zhong-Wu1,2; Feng, Guo-Shuang1,3; Li, Ji-You1,2|
|关键词||Intestinal metaplasia Subtype Follow-up Immunohistochemistry Gastric cancer|
|刊名||CHINESE JOURNAL OF CANCER RESEARCH|
|WOS标题词||Science & Technology|
|关键词[WOS]||HELICOBACTER-PYLORI INFECTION ; PRECANCEROUS LESIONS ; NATURAL-HISTORY ; CANCER ; MUCOSA ; CARCINOMA ; RISK ; STOMACH ; GENE ; CARCINOGENESIS|
To investigate the correlation of typies of gastric intestinal metaplasia(IM), expression of p53, bcl-2 and the proliferating cell nuclear antigen(PCNA), with the lesion′s evolution.
A total of 80 patients with IM(53 male and 27 female, 35-64 years old) from an area with high-risk of gastric cancer(GC) in China were enrolled into this prospective study, including 28 cases of type I (complete), 25 cases of type II (incomplete), and 27 cases of type III (incomplete). Of the 80 cases, 62 cases including 19 cases of type I, 22 type II and 21 type III, were followed up for 5-14 years(49 cases for 14 years, 6 for 10 years, and 7 for 5 years). All of the 80 cases were studied immunohistochemically for the expression of p53, bcl-2 and PCNA.
The rate of p53-expressing cases was higher in type III (25.9%) than in type I (10.7%) and type II (12.0%), but without statistical significance(P=0.3070). The positive rate of bcl-2 was obviously lower in type I (21.4%) and type II (24.0%) than in type III (37.0%), but not statistically significant(P=0.4223). We observed difference in PCNA labelling index (LI) between type II and type III (P=0.0037), and the difference was particularly significant in type I as compared with type III (P < 0.0001). There was no statistical significance between type I and type II (P=0.0616).
Evolution into GC was detected in 0%, 4.5%, and 14.3% of type I, type II, and type III IM cases, respectively. Progression to dysplasia was detected in 31.6%, 18.2%, and 14.3% of type I, type II, and type III IM cases, respectively. Persistence of IM was documented in 31.6%, 45.5%, and 42.9% of type I, type II, and type III IM cases, respectively. Regression of IM was documented in 36.8%, 31.8%, and 28.6% of type I, type II, and type III IM cases, respectively.
In progressive, persistent and regressive groups, the positive rates of p53 were 17.6%, 16.0% and 15.0%, bcl-2 were 29.4%, 36.0% and 25.0%, and PCNA LIs were 24.953 +/- 14.477, 23.752 +/- 12.934 and 25.105 +/- 10.055, respectively. There were no significant differences between the groups.
The present follow-up study indicated that type III had a higher risk for development of cancer than type I or II. PCNA LI was significantly higher in type III than in type I and II, suggesting that cell proliferation in type III was more active. Our data also indicated that the expression of p53 and bcl-2 had no apparent association with the particular type and the expression of p53, bcl-2 and PCNA had no apparent correlation with evolution of IM. Further studies with a larger sample size are needed to verify present observation.
|项目编号||2005B-44 ; 2006AA02A402 ; 2004CB518702|
|资助机构||Beijing Municipal Science & ; Technology commission NOVA program ; National "863" High-Tech Res & ; Dev program of China ; Major State Basic Research Program of china|
|作者单位||1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China|
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
3.Chaoyang Dist Ctr Dis Control & Prevent, Beijing, Peoples R China
|Sun, Yu,Li, Zhong-Wu,Feng, Guo-Shuang,et al. Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(4):272-277.|
|APA||Sun, Yu,Li, Zhong-Wu,Feng, Guo-Shuang,&Li, Ji-You.(2009).Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA.CHINESE JOURNAL OF CANCER RESEARCH,21(4),272-277.|
|MLA||Sun, Yu,et al."Long-term follow-up study on gastric intestinal metaplasia subtype and its relation to expression of P53, Bcl-2 and PCNA".CHINESE JOURNAL OF CANCER RESEARCH 21.4(2009):272-277.|