北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
RGD-modified polymeric micelles as potential carriers for targeted delivery to integrin-overexpressing tumor vasculature and tumor cells
作者: Wang, Yiguang; Wang, Xun; Zhang, Yifei; Yang, Shijin; Wang, Jiancheng; Zhang, Xuan; Zhang, Qiang
关键词: Tumor vasculature ; tumor cells ; polymeric micelles ; integrin ; targeting
刊名: JOURNAL OF DRUG TARGETING
发表日期: 2009-07-01
DOI: 10.1080/10611860902974085
卷: 17, 期:6, 页:459-467
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: STERICALLY STABILIZED LIPOSOMES ; IMPROVED ANTITUMOR EFFICACY ; BLOCK-COPOLYMER MICELLES ; IN-VIVO ; DRUG-DELIVERY ; INTRACELLULAR DELIVERY ; BREAST-CANCER ; DOXORUBICIN ; INTERNALIZATION ; NANOPARTICLES
英文摘要:

Integrins alpha v beta 3 and alpha v beta 5 are overexpressed in angiogenic tumor endothelial cells and malignant tumor cells, making them attractive targets for cancer therapy. In this study, an integrin alpha v beta 3 and alpha v beta 5 binding tripeptide, RGD (Arg-Gly-Asp), was conjugated with the surface of poly(ethylene glycol)-block-poly(D,L-lactide) (PEG-PLA) micelles. A lipophilic fluorescent probe, Dil, was loaded into both the nontargeted methoxy PEG-PLA (mPEG-PLA) micelles and the targeted RGD-modified PEG-PLA micelles. The Dil-loaded targeted micelles had a size of 24.2 nm. The targeted micelles were stable in phosphate buffered saline and exhibited a negligible leakage in culture medium. Transmission electron microscopy analysis showed that targeted micelles were spherical in shape. Cell uptake of Dil-labeled targeted micelles by human umbilical vein endothelial cells and melanoma B16 cells was investigated by spectrophotofluorometry and confocal microscopy techniques. Results revealed that RGD-modified micelles significantly facilitated the intracellular delivery of the encapsulated agents via integrin-mediated endocytosis. This study suggests that RGD-modified PEG-PLA micelles are promising drug carriers for targeted delivery to both angiogenic tumor endothelial cells and tumor cells and that the targeted micelles may be attractive carriers for combination cancer therapy against both targets.

语种: 英语
WOS记录号: WOS:000268243200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62317
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Yiguang,Wang, Xun,Zhang, Yifei,et al. RGD-modified polymeric micelles as potential carriers for targeted delivery to integrin-overexpressing tumor vasculature and tumor cells[J]. JOURNAL OF DRUG TARGETING,2009,17(6):459-467.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Yiguang]'s Articles
[Wang, Xun]'s Articles
[Zhang, Yifei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Yiguang]‘s Articles
[Wang, Xun]‘s Articles
[Zhang, Yifei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace