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Association of an Impaired Bone Marrow Microenvironment with Secondary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation
Kong, Yuan1; Chang, Ying-Jun1; Wang, Ya-Zhe1; Chen, Yu-Hong1; Han, Wei1; Wang, Yu1; Sun, Yu-Qian1; Yan, Chen-Hua1; Wang, Feng-Rong1; Liu, Yan-Rong1; Xu, Lan-Ping1; Liu, Dai-Hong1; Huang, Xiao-Jun1,2
关键词Poor graft function Secondary Allogeneic hematopoietic stem cell transplantation Bone marrow Microenvironment
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2013-10-01
DOI10.1016/j.bbmt.2013.07.014
19期:10页:1465-1473
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; ACUTE MYELOID-LEUKEMIA ; 1ST COMPLETE REMISSION ; RISK ACUTE-LEUKEMIA ; PROGENITOR CELLS ; NICHE ; CHEMOTHERAPY ; ENGRAFTMENT ; RECOVERY ; OUTCOMES
英文摘要

Poor graft function (PGF) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Whether abnormalities of the bone marrow (BM) microenvironment are involved in the pathogenesis of PGF is unclear. In the present prospective nested case-control study, 19 patients with secondary PGF, 38 matched patients with good graft function (GGF) after allo-HSCT, and 15 healthy donors (HDs) were enrolled. The cellular elements of the BM microenvironment, including endosteal cells, perivascular cells, and vascular cells, were analyzed by flow cytometry as well as hematoxylin and eosin and immunohistochemical staining in situ. The median time to occurrence of secondary PGF was 90 days post-transplantation (range, 58 to 264 days). The patients with PGF showed markedly hypocellular marrow (10% versus 45% versus 45%; P < .0001) with scattered hematopoietic cells and significantly lower CD34(+) cells (0.07% versus 0.26% versus 0.26%; P < .0001), endosteal cells (4 per high-power field [hpf] versus 16 per hpf versus 20 per hpf; P < .001), perivascular cells (0.008% versus 0.10% versus 0.12%; P < .0001), and endothelial progenitor cells (0.008% versus 0.16% versus 0.18%; P < .0001) compared with GGF allo-HSCT recipients and HDs, respectively. Multivariate analyses revealed that endothelial progenitor cells (odds ratio, 150.72; P = .001) and the underlying disease (odds ratio, 18.52; P = .007) were independent risk factors for secondary PGF. Our results suggest that the impaired BM microenvironment may contribute to the occurrence of secondary PGF post-HSCT. (C) 2013 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000324975000010
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62321
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位1.Peking Univ, Inst Hematol, Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Kong, Yuan,Chang, Ying-Jun,Wang, Ya-Zhe,et al. Association of an Impaired Bone Marrow Microenvironment with Secondary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2013,19(10):1465-1473.
APA Kong, Yuan.,Chang, Ying-Jun.,Wang, Ya-Zhe.,Chen, Yu-Hong.,Han, Wei.,...&Huang, Xiao-Jun.(2013).Association of an Impaired Bone Marrow Microenvironment with Secondary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,19(10),1465-1473.
MLA Kong, Yuan,et al."Association of an Impaired Bone Marrow Microenvironment with Secondary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19.10(2013):1465-1473.
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