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学科主题: 公共卫生
题名:
A Longitudinal Study of Carotid Plaque and Risk of Ischemic Cardiovascular Disease in the Chinese Population
作者: Xie, Wuxiang1; Wu, Yangfeng1; Wang, Wei2; Zhao, Dong2; Liang, Lirong3; Wang, Miao2; Yang, Ying4; Sun, Jiayi2; Shi, Ping5; Huo, Yong4
关键词: Carotid plaque ; Ischemic cardiovascular disease ; Chinese
刊名: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
发表日期: 2011-07-01
DOI: 10.1016/j.echo.2011.02.011
卷: 24, 期:7, 页:729-737
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: INTIMA-MEDIA THICKNESS ; CORONARY-HEART-DISEASE ; REPUBLIC-OF-CHINA ; MYOCARDIAL-INFARCTION ; ATHEROSCLEROSIS RISK ; PREDICTIVE-VALUE ; WALL THICKNESS ; MONICA PROJECT ; ARTERY INTIMA ; STROKE
英文摘要:

Background: The aim of this study was to investigate the role of carotid plaque in predicting ischemic cardiovascular risk, which has been intensively reported in Western populations but not yet in the Chinese population, in which the cardiovascular disease profile is significantly different.

Methods: Cox proportional-hazards regression was used to analyze associations between the presence of carotid plaque and the number of segments of carotid arteries with plaque (total plaque score) and the risk for subsequent ischemic cardiovascular disease (ICVD) events, including ischemic stroke and coronary heart disease, in 3,258 Chinese men and women aged 38 to 79 years at baseline. During 5 years of follow-up, 137 ICVD events were identified.

Results: The person-year incidence was 10.6 per 1,000 for ICVD, 6.7 per 1,000 for ischemic stroke, and 4.4 per 1,000 for coronary heart disease. After adjustment for conventional cardiovascular risk factors, the risk for ICVD was significantly associated with the presence of carotid plaque (hazard ratio, 1.49; 95% confidence interval [CI], 1.05-2.14) and total plaque score (hazard ratio per 1-score increase, 1.25; 95% CI, 1.04-1.50). Further analysis showed that the multivariate-adjusted hazard ratio of ICVD associated with plaque in common carotid arteries was 1.90 (95% CI, 1.15-3.13) and that with plaque in bifurcations was 1.26 (95% CI, 0.86-1.85). The results of separate analyses for ischemic stroke and coronary heart disease paralleled those for ICVD. The addition of total plaque score to the risk prediction model resulted in a significant improvement in risk estimation when measured by net reclassification improvement index.

Conclusions: Carotid plaque adds significant additional information for predicting the risk for ICVD events in the Chinese population. (J Am Soc Echocardiogr 2011;24:729-37.)

语种: 英语
所属项目编号: 2001BA703B01 ; 2006BAI01A02
项目资助者: People&prime ; s Republic of China Ministry of Science and Technology ; Ministry of Health
WOS记录号: WOS:000291975000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62323
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China
3.Capital Med Univ, Beijing Chaoyang Hosp, Beijing, Peoples R China
4.Peking Univ First Hosp, Dept Cardiol, Beijing, Peoples R China
5.Shijingshan Ctr Dis Prevent & Control, Shijingshan Chron Dis Prevent & Control Inst, Beijing, Peoples R China

Recommended Citation:
Xie, Wuxiang,Wu, Yangfeng,Wang, Wei,et al. A Longitudinal Study of Carotid Plaque and Risk of Ischemic Cardiovascular Disease in the Chinese Population[J]. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY,2011,24(7):729-737.
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