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学科主题: 临床医学
题名:
Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth
作者: Toernkvist, Maria1; Natalishvili, Natalia1; Xie, Yuntao1,2; Girnita, Ada1; D′ Arcy, Padraig1; Brodin, Bertha1; Axelson, Magnus3; Girnita, Leonard1
关键词: synovial sarcoma ; SS18-SSX ; IGF-1 receptor ; growth ; apoptosis
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2008-04-11
DOI: 10.1016/j.bbrc.2008.01.162
卷: 368, 期:3, 页:793-800
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: SYT-SSX ; CYCLOLIGNAN PPP ; INSULIN-LIKE-GROWTH-FACTOR-1 RECEPTOR ; INCREASED EXPRESSION ; TYROSINE KINASE ; BETA-ARRESTIN ; INHIBITION ; CANCER ; IGF-1 ; IDENTIFICATION
英文摘要:

Recently we demonstrated that the synovial sarcoma specific fusion gene SS18-SSX is crucial for cyclin D1 expression and is linked to cell proliferation. In this report we explore the role of SS18-SSX and IGF-1R for their potential functions in cellular proliferation and survival in cultured synovial sarcoma cells. We found that targeting of SS18-SSX mRNA by antisense oligonucleotide treatment drastically and rapidly decreased cell proliferation but caused only a slight increase of apoptosis. The synovial sarcoma cells were confirmed to express IGF-1R, and treatment with an IGF-1R inhibitor resulted in substantially reduced cell viability by inducing apoptosis in these cells. Conversely, inhibition of the IGF-1R resulted only in a slight to moderate decrease in DNA synthesis. In conclusion, SS18-SSX and IGF-1R seem to play important but different roles in maintaining malignant growth of synovial sarcoma cells. Whereas SS18-SSX maintains cyclin D1 and cell proliferation, IGF-1R protects from apoptosis. (c) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000253925900054
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62332
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Karolinska Inst, Dept Pathol & Oncol, CCK, S-17176 Stockholm, Sweden
2.Peking Univ, Beijing Canc Hosp, Dept Surg, Beijing 100871, Peoples R China
3.Karolinska Hosp, Dept Clin Chem, S-10401 Stockholm, Sweden

Recommended Citation:
Toernkvist, Maria,Natalishvili, Natalia,Xie, Yuntao,et al. Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,368(3):793-800.
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