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学科主题: 精神卫生
题名:
Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors
作者: Su, Yun-Ai; Si, Tian-Mei; Zhou, Dong-Feng; Guo, Chun-Mei; Wang, Xiao-Dong; Yang, Yang; Shu, Liang; Liang, Jian-Hui
关键词: MK-801 ; risperidone ; hyperlocomotion ; serotonin ; (mice)
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2007-06-14
DOI: 10.1016/j.ejphar.2007.02.031
卷: 564, 期:1-3, 页:123-130
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ANTIPSYCHOTIC-DRUGS ; PREFRONTAL CORTEX ; DOPAMINE D-1 ; IN-VITRO ; PHENCYCLIDINE ; SCHIZOPHRENIA ; CLOZAPINE ; ANTAGONIST ; NEUROTRANSMISSION ; HALOPERIDOL
英文摘要:

Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists, like phencyclidine (PCP), elicit schizophrenia-like symptoms in humans and behavioral abnormalities in animals, such as hyperactivity. We investigated the effect of the atypical antipsychotic risperidone on hyperlocomotion produced in mice by 5,R,10S-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine hydrogen maleate (MK-801), an NMDA receptor antagonist. MK-801 (0.125, 0.25, 0.50 mg/kg) dose-dependently increased the total distance traveled in an open field during a 90 min period in mice. The increase in MK-801 (0.25 mg/kg)-induced total distance traveled was attenuated by pretreatment with risperidone at doses that alone had no effect on spontaneous locomotor activity. Furthermore, (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), a serotonin 5-HT2A/2C receptor agonist, at the doses that failed to change spontaneous locomotor activity or hyperlocomotion induced by MK-801, reversed the attenuation by risperidone. The serotonin 5-HT2A/2c receptor antagonist, ritanserin, enhanced the inhibitory effect of risperidone. These findings indicate that risperidone attenuates MK-801-induced hyperlocomotion in mice by blocking serotonin 5-HT2A/2c receptors. (c) 2007 Elsevier B.V All rights reserved.

语种: 英语
WOS记录号: WOS:000246998800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62333
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Su, Yun-Ai,Si, Tian-Mei,Zhou, Dong-Feng,et al. Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,564(1-3):123-130.
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