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Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors
Su, Yun-Ai; Si, Tian-Mei; Zhou, Dong-Feng; Guo, Chun-Mei; Wang, Xiao-Dong; Yang, Yang; Shu, Liang; Liang, Jian-Hui
关键词MK-801 risperidone hyperlocomotion serotonin (mice)
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2007-06-14
DOI10.1016/j.ejphar.2007.02.031
564期:1-3页:123-130
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ANTIPSYCHOTIC-DRUGS ; PREFRONTAL CORTEX ; DOPAMINE D-1 ; IN-VITRO ; PHENCYCLIDINE ; SCHIZOPHRENIA ; CLOZAPINE ; ANTAGONIST ; NEUROTRANSMISSION ; HALOPERIDOL
英文摘要

Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists, like phencyclidine (PCP), elicit schizophrenia-like symptoms in humans and behavioral abnormalities in animals, such as hyperactivity. We investigated the effect of the atypical antipsychotic risperidone on hyperlocomotion produced in mice by 5,R,10S-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine hydrogen maleate (MK-801), an NMDA receptor antagonist. MK-801 (0.125, 0.25, 0.50 mg/kg) dose-dependently increased the total distance traveled in an open field during a 90 min period in mice. The increase in MK-801 (0.25 mg/kg)-induced total distance traveled was attenuated by pretreatment with risperidone at doses that alone had no effect on spontaneous locomotor activity. Furthermore, (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), a serotonin 5-HT2A/2C receptor agonist, at the doses that failed to change spontaneous locomotor activity or hyperlocomotion induced by MK-801, reversed the attenuation by risperidone. The serotonin 5-HT2A/2c receptor antagonist, ritanserin, enhanced the inhibitory effect of risperidone. These findings indicate that risperidone attenuates MK-801-induced hyperlocomotion in mice by blocking serotonin 5-HT2A/2c receptors. (c) 2007 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000246998800016
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62333
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
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Su, Yun-Ai,Si, Tian-Mei,Zhou, Dong-Feng,et al. Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,564(1-3):123-130.
APA Su, Yun-Ai.,Si, Tian-Mei.,Zhou, Dong-Feng.,Guo, Chun-Mei.,Wang, Xiao-Dong.,...&Liang, Jian-Hui.(2007).Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors.EUROPEAN JOURNAL OF PHARMACOLOGY,564(1-3),123-130.
MLA Su, Yun-Ai,et al."Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors".EUROPEAN JOURNAL OF PHARMACOLOGY 564.1-3(2007):123-130.
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