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Targeting Epirubicin Plus Quinacrine Liposomes Modified with DSPE-PEG(2000)-C(RGDfK) Conjugate for Eliminating Invasive Breast Cancer
Sun, Meng-Ge; Shi, Ji-Feng; Li, Xiu-Ying; Zhao, Yao; Ju, Rui-Jun; Mu, Li-Min; Yan, Yan; Li, Xue-Tao; Zeng, Fan; Lu, Wan-Liang
关键词Targeting Epirubicin Plus Quinacrine Liposomes Invasive Breast Cancer Vasculogenic Mimicry Channels Marker Molecules Efficacy
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
2015-08-01
DOI10.1166/jbn.2015.2079
11期:8页:1339-1353
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Biomaterials
资助者National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China ; Innovation Team of Ministry of Education ; National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China ; Innovation Team of Ministry of Education
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]CELL VASCULOGENIC MIMICRY ; DRUG-INDUCED APOPTOSIS ; HUMAN-MELANOMA CELLS ; VE-CADHERIN ; STEM-CELLS ; TUMOR ; SURVIVAL ; INTEGRIN ; METASTASIS ; ACTIVATION
英文摘要

Recurrence of invasive breast cancer could arise from the residual cancer cells after comprehensive treatment. It is possible that residual invasive cancer cells are capable of forming highly patterned vasculogenic mimicry (VM) channels, leading to relapse and metastasis. In the present study, a new type of targeting epirubicin plus quinacrine liposomes was developed by modifying functional DSPE-PEG(2000) with C(RGDfK), a cyclic peptide containing Arg-Gly-Asp. These liposomes could potentially eliminate invasive breast cancer and destroy VM channels. Evaluations were made in human invasive breast cancer cells and their xenografts in nude mice. The results showed that the targeting epirubicin plus quinacrine liposomes could enhance the accumulation and uptake of the drugs in cancer tissues, kill cancer cells directly, activate apoptotic enzymes, destroy the VM channels and downregulate the VM channel-forming marker molecules (EphA2, FAK, PI3K, MMP 9, MMP 14, VE-Cad and HIF-alpha), thereby exhibiting a strong overall anticancer efficacy. The targeting epirubicin plus quinacrine liposomes provided a promising strategy to treat invasive breast cancer and to prevent the relapse arising from VM channels after chemotherapy.

语种英语
所属项目编号2013CB932501 ; 7131009 ; 81373343 ; BMU20110263
资助者National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China ; Innovation Team of Ministry of Education ; National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China ; Innovation Team of Ministry of Education
WOS记录号WOS:000351892100004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62337
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sun, Meng-Ge,Shi, Ji-Feng,Li, Xiu-Ying,et al. Targeting Epirubicin Plus Quinacrine Liposomes Modified with DSPE-PEG(2000)-C(RGDfK) Conjugate for Eliminating Invasive Breast Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2015,11(8):1339-1353.
APA Sun, Meng-Ge.,Shi, Ji-Feng.,Li, Xiu-Ying.,Zhao, Yao.,Ju, Rui-Jun.,...&Lu, Wan-Liang.(2015).Targeting Epirubicin Plus Quinacrine Liposomes Modified with DSPE-PEG(2000)-C(RGDfK) Conjugate for Eliminating Invasive Breast Cancer.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,11(8),1339-1353.
MLA Sun, Meng-Ge,et al."Targeting Epirubicin Plus Quinacrine Liposomes Modified with DSPE-PEG(2000)-C(RGDfK) Conjugate for Eliminating Invasive Breast Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11.8(2015):1339-1353.
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