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学科主题: 药学
题名:
Targeting Epirubicin Plus Quinacrine Liposomes Modified with DSPE-PEG(2000)-C(RGDfK) Conjugate for Eliminating Invasive Breast Cancer
作者: Sun, Meng-Ge; Shi, Ji-Feng; Li, Xiu-Ying; Zhao, Yao; Ju, Rui-Jun; Mu, Li-Min; Yan, Yan; Li, Xue-Tao; Zeng, Fan; Lu, Wan-Liang
关键词: Targeting Epirubicin Plus Quinacrine Liposomes ; Invasive Breast Cancer ; Vasculogenic Mimicry Channels ; Marker Molecules ; Efficacy
刊名: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
发表日期: 2015-08-01
DOI: 10.1166/jbn.2015.2079
卷: 11, 期:8, 页:1339-1353
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Biomaterials
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
关键词[WOS]: CELL VASCULOGENIC MIMICRY ; DRUG-INDUCED APOPTOSIS ; HUMAN-MELANOMA CELLS ; VE-CADHERIN ; STEM-CELLS ; TUMOR ; SURVIVAL ; INTEGRIN ; METASTASIS ; ACTIVATION
英文摘要:

Recurrence of invasive breast cancer could arise from the residual cancer cells after comprehensive treatment. It is possible that residual invasive cancer cells are capable of forming highly patterned vasculogenic mimicry (VM) channels, leading to relapse and metastasis. In the present study, a new type of targeting epirubicin plus quinacrine liposomes was developed by modifying functional DSPE-PEG(2000) with C(RGDfK), a cyclic peptide containing Arg-Gly-Asp. These liposomes could potentially eliminate invasive breast cancer and destroy VM channels. Evaluations were made in human invasive breast cancer cells and their xenografts in nude mice. The results showed that the targeting epirubicin plus quinacrine liposomes could enhance the accumulation and uptake of the drugs in cancer tissues, kill cancer cells directly, activate apoptotic enzymes, destroy the VM channels and downregulate the VM channel-forming marker molecules (EphA2, FAK, PI3K, MMP 9, MMP 14, VE-Cad and HIF-alpha), thereby exhibiting a strong overall anticancer efficacy. The targeting epirubicin plus quinacrine liposomes provided a promising strategy to treat invasive breast cancer and to prevent the relapse arising from VM channels after chemotherapy.

语种: 英语
所属项目编号: 2013CB932501 ; 7131009 ; 81373343 ; BMU20110263
项目资助者: National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China ; Innovation Team of Ministry of Education
WOS记录号: WOS:000351892100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62337
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Meng-Ge,Shi, Ji-Feng,Li, Xiu-Ying,et al. Targeting Epirubicin Plus Quinacrine Liposomes Modified with DSPE-PEG(2000)-C(RGDfK) Conjugate for Eliminating Invasive Breast Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2015,11(8):1339-1353.
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