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学科主题基础医学
DPP6 Establishes the A-Type K+ Current Gradient Critical for the Regulation of Dendritic Excitability in CA1 Hippocampal Neurons
Sun, Wei1,2,3; Maffie, Jon K.4,5; Lin, Lin1; Petralia, Ronald S.6; Rudy, Bernardo4,5; Hoffman, Dax A.1
刊名NEURON
2011-09-22
DOI10.1016/j.neuron.2011.08.008
71期:6页:1102-1115
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PYRAMIDAL NEURONS ; POTASSIUM CHANNELS ; ACTION-POTENTIALS ; APICAL DENDRITES ; DOWN-REGULATION ; ALPHA-SUBUNITS ; KV4.2 CHANNELS ; PROTEIN DPPX ; RAT-BRAIN ; MODULATION
英文摘要

Subthreshold-activating A-type K+ currents are essential for the proper functioning of the brain, where they act to delay excitation and regulate firing frequency. In CA1 hippocampal pyramidal neuron dendrites, the density of A-type K+ current increases with distance from the soma, playing an important role in synaptic integration and plasticity. The mechanism underlying this gradient has, however, remained elusive. Here, dendritic recordings from mice lacking the Kv4 transmembrane auxiliary subunit DPP6 revealed that this protein is critical for generating the A-current gradient. Loss of DPP6 led to a decrease in A-type current, specifically in distal dendrites. Decreased current density was accompanied by a depolarizing shift in the voltage dependence of channel activation. Together these changes resulted in hyperexcitable dendrites with enhanced dendritic AP back-propagation, calcium electrogenesis, and induction of synaptic long-term potentiation. Despite enhanced dendritic excitability, firing behavior evoked by somatic current injection was mainly unaffected in DPP6-KO recordings, indicating compartmentalized regulation of neuronal excitability.

语种英语
WOS记录号WOS:000295556500014
项目编号NS045217 ; 5F30NS071660
资助机构NICHD ; NIDCD ; NINDS ; NIH
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被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62338
专题北京大学基础医学院_神经生物学系
作者单位1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Mol Neurophysiol & Biophys Unit, NIH, Bethesda, MD 20892 USA
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 01082801114, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 01082801114, Peoples R China
4.NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA
5.NYU, Sch Med, Smilow Neurosci Program, New York, NY 10016 USA
6.Natl Inst Deafness & Other Commun Disorders, Neurochem Lab, NIH, Bethesda, MD 20892 USA
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GB/T 7714
Sun, Wei,Maffie, Jon K.,Lin, Lin,et al. DPP6 Establishes the A-Type K+ Current Gradient Critical for the Regulation of Dendritic Excitability in CA1 Hippocampal Neurons[J]. NEURON,2011,71(6):1102-1115.
APA Sun, Wei,Maffie, Jon K.,Lin, Lin,Petralia, Ronald S.,Rudy, Bernardo,&Hoffman, Dax A..(2011).DPP6 Establishes the A-Type K+ Current Gradient Critical for the Regulation of Dendritic Excitability in CA1 Hippocampal Neurons.NEURON,71(6),1102-1115.
MLA Sun, Wei,et al."DPP6 Establishes the A-Type K+ Current Gradient Critical for the Regulation of Dendritic Excitability in CA1 Hippocampal Neurons".NEURON 71.6(2011):1102-1115.
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