IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心
学科主题临床医学
Surgical Treatment for Patients with Krukenberg Tumor of Stomach Origin: Clinical Outcome and Prognostic Factors Analysis
Peng, Wei1,6; Hua, Rui-Xi1,5,6; Jiang, Rong2,6; Ren, Chao3; Jia, Yong-Nin4; Li, Jin1,6; Guo, Wei-Jian1,6
刊名PLOS ONE
2013-07-09
DOI10.1371/journal.pone.0068227
8期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CANCER STEM-CELLS ; HUMAN OVARIAN-CANCER ; GASTRIC-CANCER ; CD133 EXPRESSION ; SELF-RENEWAL ; PHASE-III ; CARCINOMA ; CARCINOGENESIS ; IDENTIFICATION ; FLUOROURACIL
英文摘要

Krukenberg tumor originated from stomach in female patients is common in clinical practice, but it is still uncertain whether surgical resection of ovarian metastases could improve the outcome. Some studies suggested that a certain group of patients could benefit from the resection of ovarian metastases. However, conclusions were different between studies and there was no data to illustrate if certain molecular markers were associated with patients′ survival. In this study, we analyzed the effects of resection of ovarian metastases, and investigated prognostic factors in 133 patients with ovarian metastases originated from stomach. Furthermore, we examined the expression of some cancer stem cells (CSCs) markers or related molecules in 64 ovarian metastases specimens and analyzed the correlation between these molecules and patients′ survival. We found that the median overall survival (mOS) of all 133 patients was 16 months, and "gastrectomy" and "without ascites" were two independent prognostic factors associated with longer survival. The mOS of the patients with gastrectomy was longer than that of patients had not undergone gastrectomy (19 vs. 9 months, p = 0.048). Patients without ascites survived longer than those with ascites (mOS: 21 vs. 13 months, p = 0.008). We also found that Sox2, CD44 or CD133 positive expression in ovarian metastases were risk factors correlated with poor survival, and Sox2 expression was an independent prognostic indicator. These results suggested that ovarian metastasectomy might help to prolong the survivor of some patients with Krukenberg tumor originated from stomach. Patients without ascites, and with resected or resectable primary gastric cancer lesion could get benefit from and be potential candidate for surgical treatment. The expression of Sox2 might serve as a prognostic indicator for predicting patients′ survival and be helpful for selecting patients in future.

语种英语
WOS记录号WOS:000321736900071
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62342
Collection北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Fudan Univ, Shanghai Canc Ctr, Dept Med Oncol, Shanghai 200433, Peoples R China
2.Fudan Univ, Shanghai Canc Ctr, Ovarian Canc Program, Dept Gynecol, Shanghai 200433, Peoples R China
3.Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Gastrointestinal Surg, Beijing 100871, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Oncol, Guangzhou 510275, Guangdong, Peoples R China
6.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China
Recommended Citation
GB/T 7714
Peng, Wei,Hua, Rui-Xi,Jiang, Rong,et al. Surgical Treatment for Patients with Krukenberg Tumor of Stomach Origin: Clinical Outcome and Prognostic Factors Analysis[J]. PLOS ONE,2013,8(7).
APA Peng, Wei.,Hua, Rui-Xi.,Jiang, Rong.,Ren, Chao.,Jia, Yong-Nin.,...&Guo, Wei-Jian.(2013).Surgical Treatment for Patients with Krukenberg Tumor of Stomach Origin: Clinical Outcome and Prognostic Factors Analysis.PLOS ONE,8(7).
MLA Peng, Wei,et al."Surgical Treatment for Patients with Krukenberg Tumor of Stomach Origin: Clinical Outcome and Prognostic Factors Analysis".PLOS ONE 8.7(2013).
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