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The Clinical Profile and Prognosis of Chinese Children with Melamine-Induced Kidney Disease: A Systematic Review and Meta-Analysis
Wang, Pei-Xin1,2,3; Li, Hong-Tian1,2; Zhang, Long1,2; Liu, Jian-Meng1,2
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/868202
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]FOLLOW-UP ; URINARY STONES ; YOUNG-CHILDREN ; OUTCOMES ; UROLITHIASIS ; DEPRESSION ; PRODUCTS ; FORMULA ; RISK
英文摘要

Introduction. Studies have reported inconsistent results regarding clinical feature and the prognosis status of the affected children in China melamine-contamination event. We summarized available literatures by performing a review and meta-analysis. Methods. Statistical pooling was performed using random-effects model; the sources of heterogeneity were explored through subgroup analyses. Results. Twenty-six studies involving 2164 patients with kidney abnormalities were identified; 94.4% of the patients had urinary calculi and 95.8% of the calculi were <10mm in diameter. Of 2040 patients with known types of treatment, 5.6% underwent surgical treatment. The pooled recovery rates at 1, 3, 6, and 12 months after diagnosis or treatment initiation were 67.1%, 76.3%, 85.4%, and 92.3%, respectively; these pooled rates did not differ between the study subgroups stratified by mean age at diagnosis, mean duration of melamine exposure, types of patients (inpatient/outpatient), and treatment types (specific/nonspecific), except that the 1-month recovery rate for studies involving a specific treatment (71.9%) was higher than that for studies involving nonspecific treatment (46.2%). Conclusion. The majority of patients had small calculi and could recover without surgical treatment. Kidney abnormalities remained in about 8% of the patients at 12-month followup, indicating a need for longer-term followup.

语种英语
WOS记录号WOS:000323353300001
项目编号81072372
资助机构National Nature Science Foundation of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62343
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学第三临床医学院_介入血管外科
作者单位1.Guangxi Adm Work Safety, Nanning 530022, Peoples R China
2.Peking Univ, Sch Publ Hlth, Inst Reprod & Child Hlth, Minist Hlth,Key Lab Reprod Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Pei-Xin,Li, Hong-Tian,Zhang, Long,et al. The Clinical Profile and Prognosis of Chinese Children with Melamine-Induced Kidney Disease: A Systematic Review and Meta-Analysis[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Wang, Pei-Xin,Li, Hong-Tian,Zhang, Long,&Liu, Jian-Meng.(2013).The Clinical Profile and Prognosis of Chinese Children with Melamine-Induced Kidney Disease: A Systematic Review and Meta-Analysis.BIOMED RESEARCH INTERNATIONAL.
MLA Wang, Pei-Xin,et al."The Clinical Profile and Prognosis of Chinese Children with Melamine-Induced Kidney Disease: A Systematic Review and Meta-Analysis".BIOMED RESEARCH INTERNATIONAL (2013).
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