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Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats
Bao, Lei; Zhang, Zhaofeng; Dai, Xiaoqian; Ding, Ye; Jiang, Yanfei; Li, Yujie; Li, Yong
关键词diabetic nephropathy antioxidative activities rats inflammatory grape seed proanthocyanidin extract
刊名MOLECULAR MEDICINE REPORTS
2015
DOI10.3892/mmr.2014.2768
11期:1页:645-652
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]OXIDATIVE STRESS ; DB/DB MICE ; NEPHROPATHY ; INFLAMMATION ; COMPLICATIONS ; EXPRESSION ; KIDNEY ; MATRIX ; ANTIOXIDANT ; INDUCTION
英文摘要

Grape seed proanthocyanidin extract (GSPE) is known to be an effective natural polyphenol capable of removing free radicals in vivo. It has been reported that GSPE has biological functions including antioxidant, anti-cancer, anti-hyperglycemic, anti-radiation, and prevention and treatment of cardiovascular diseases. This study aims to investigate the effects of GSPE on renal injury in type 2 diabetic rats induced with low-dose streptozotocin and a high-carbohydrate/high-fat diet. Rats (n=12 per group) were administered GSPE at either a low (125 mg/kg.bw), medium (250 mg/kg.bw) or high (500 mg/kg.bw) dose, while control rats and diabetes mellitus group rats received no specific treatment. After 16 weeks, GSPE slightly increased body weight and decreased food consumption, water intake and urine volume in rats. Diabetic rats treated with GSPE demonstrated decreased fasting blood glucose, serum insulin, HbA1c and systolic blood pressure (P<0.05). GSPE significantly improved renal function parameters, reduced the expression of tissue inhibitor of metalloproteinase-1 and also increased the activity of matrix metalloproteinase-9. Moreover, GSPE (particularly at a dose of 500 mg/kg.bw) increased the activity of antioxidant enzymes and reduced the levels of c-reactive proteins (P<0.01) in serum and the expression of tumor necrosis factor-, monocyte chemoattractant protein-1 and intercellular adhesion molecule-1 (P<0.05) in the kidney. These findings suggest that GSPE ameliorates renal injury in type 2 diabetic rats through its antioxidative activity and anti-inflammatory effects.

语种英语
所属项目编号81102116 ; 81072293
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000346651100094
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62345
Collection北京大学公共卫生学院
作者单位Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Bao, Lei,Zhang, Zhaofeng,Dai, Xiaoqian,et al. Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats[J]. MOLECULAR MEDICINE REPORTS,2015,11(1):645-652.
APA Bao, Lei.,Zhang, Zhaofeng.,Dai, Xiaoqian.,Ding, Ye.,Jiang, Yanfei.,...&Li, Yong.(2015).Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats.MOLECULAR MEDICINE REPORTS,11(1),645-652.
MLA Bao, Lei,et al."Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats".MOLECULAR MEDICINE REPORTS 11.1(2015):645-652.
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