IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress
Cai, Huaiqiu1; Zhang, Gaigai2; Chen, Wenjia1; Zhang, Bo1; Zhang, Jinsheng3; Chang, Jinrui3; Tang, Chaoshu3; Qi, Yongfen3; Yin, Xinhua1
刊名PHARMAZIE
2014
DOI10.1691/ph.2014.3663
69期:1页:64-69
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]BRAIN NATRIURETIC PEPTIDE ; IMPROVES CARDIAC-FUNCTION ; HEART-FAILURE ; ISCHEMIA/REPERFUSION INJURY ; INTERMEDIN(1-53) PROTECTS ; GHRELIN PROTECTS ; ISCHEMIC-HEART ; IN-VIVO ; KINASE ; ACTIVATION
英文摘要

Clinical studies have suggested that metformin, a widely used antidiabetic agent, exerts a direct cardioprotective effect on cardiovascular disease in addition to its blood glucose-lowering activity. This study was designed to identify the role of metformin in rats with isoproterenol (ISO)-induced myocardial injury and to investigate its underlying mechanism. A rat model of myocardial ischemic injury was established by the subcutaneous injection of a high dose of ISO, a p-adrenergic agonist. The results showed that pretreatment of metformin significantly reduced rat mortality induced by ISO, attenuated the increased plasma lactate dehydrogenase activity and myocardium malondialdehyde level, alleviated the hemodynamic disturbance, inhibited the upregulated gene expression of myocardial probrain natriuretic peptide and alleviated the myocardial morphological injury and apoptosis induced by ISO. Furthermore, western blot analysis showed that metformin suppressed the overexpression of the endoplasmic reticulum stress (ERS) markers cleaved caspase-12 and CEBP-homologous protein induced by ISO and increased the phosphorylation of AMP-activated protein kinase (AMPK). In conclusion, these data suggest that metformin might protect the myocardium against acute ischemic injury in rats at least partially by activating AMPK and alleviating aberrant ERS. These findings might provide further experimental evidence for treating patients at risk of ischemic heart disease with mefformin.

语种英语
WOS记录号WOS:000334259500013
项目编号81000046 ; 81170082
资助机构National Natural Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62347
专题北京大学基础医学院_心血管所
作者单位1.Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150086, Peoples R China
2.Tsinghua Univ, Affiliated Hosp 1, Beijing Huaxin Hosp, Dept Geriatr & Gerontol, Beijing 100016, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China
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GB/T 7714
Cai, Huaiqiu,Zhang, Gaigai,Chen, Wenjia,et al. Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress[J]. PHARMAZIE,2014,69(1):64-69.
APA Cai, Huaiqiu.,Zhang, Gaigai.,Chen, Wenjia.,Zhang, Bo.,Zhang, Jinsheng.,...&Yin, Xinhua.(2014).Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress.PHARMAZIE,69(1),64-69.
MLA Cai, Huaiqiu,et al."Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress".PHARMAZIE 69.1(2014):64-69.
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