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学科主题: 基础医学
题名:
Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress
作者: Cai, Huaiqiu1; Zhang, Gaigai2; Chen, Wenjia1; Zhang, Bo1; Zhang, Jinsheng3; Chang, Jinrui3; Tang, Chaoshu3; Qi, Yongfen3; Yin, Xinhua1
刊名: PHARMAZIE
发表日期: 2014
DOI: 10.1691/ph.2014.3663
卷: 69, 期:1, 页:64-69
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: BRAIN NATRIURETIC PEPTIDE ; IMPROVES CARDIAC-FUNCTION ; HEART-FAILURE ; ISCHEMIA/REPERFUSION INJURY ; INTERMEDIN(1-53) PROTECTS ; GHRELIN PROTECTS ; ISCHEMIC-HEART ; IN-VIVO ; KINASE ; ACTIVATION
英文摘要:

Clinical studies have suggested that metformin, a widely used antidiabetic agent, exerts a direct cardioprotective effect on cardiovascular disease in addition to its blood glucose-lowering activity. This study was designed to identify the role of metformin in rats with isoproterenol (ISO)-induced myocardial injury and to investigate its underlying mechanism. A rat model of myocardial ischemic injury was established by the subcutaneous injection of a high dose of ISO, a p-adrenergic agonist. The results showed that pretreatment of metformin significantly reduced rat mortality induced by ISO, attenuated the increased plasma lactate dehydrogenase activity and myocardium malondialdehyde level, alleviated the hemodynamic disturbance, inhibited the upregulated gene expression of myocardial probrain natriuretic peptide and alleviated the myocardial morphological injury and apoptosis induced by ISO. Furthermore, western blot analysis showed that metformin suppressed the overexpression of the endoplasmic reticulum stress (ERS) markers cleaved caspase-12 and CEBP-homologous protein induced by ISO and increased the phosphorylation of AMP-activated protein kinase (AMPK). In conclusion, these data suggest that metformin might protect the myocardium against acute ischemic injury in rats at least partially by activating AMPK and alleviating aberrant ERS. These findings might provide further experimental evidence for treating patients at risk of ischemic heart disease with mefformin.

语种: 英语
所属项目编号: 81000046 ; 81170082
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000334259500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62347
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150086, Peoples R China
2.Tsinghua Univ, Affiliated Hosp 1, Beijing Huaxin Hosp, Dept Geriatr & Gerontol, Beijing 100016, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China

Recommended Citation:
Cai, Huaiqiu,Zhang, Gaigai,Chen, Wenjia,et al. Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress[J]. PHARMAZIE,2014,69(1):64-69.
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