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学科主题: 临床医学
题名:
Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxide
作者: Sun Yun1; Wang Xin-mao2; Chen Ya-hong1; Zhu Rui-xia1; Liao Cheng-cheng1
关键词: chronic obstructive pulmonary disease ; nitric oxide ; hydrogen sulfide
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-09-05
DOI: 10.3760/cma.j.issn.0366-6999.20123064
卷: 126, 期:17, 页:3240-3244
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: OXIDATIVE STRESS ; SODIUM SULFIDE ; ASTHMA ; BREATH ; COPD ; SPUTUM ; RATS ; GAS
英文摘要:

Background Exhaled nitric oxide (NO) is a noninvasive biomarker of airway inflammation in pulmonary diseases. Hydrogen sulfide (H2S), as the third member of the gasotransmitter family, is involved in the pathophysiological process in lung diseases. H2S also exists in exhaled breath and can be sampled non-invasively. The study investigated the level of exhaled H2S in patients with chronic obstructive pulmonary disease (COPD) and its correlation with exhaled NO.

Methods Levels of exhaled NO and H2S, lung function, and cell differential counts in induced sputum were studied in 19 patients with acute exacerbation of COPD (AECOPD), 19 patients with stable COPD and seven healthy smoke controls.

Results Exhaled H2S levels were similar in patients with AECOPD (10.0 parts per billion (ppb), 8.0-13.0 ppb), stable COPD (10.0 ppb, 9.0-12.0 ppb), and healthy controls (9.0 ppb, 8.0-16.0 ppb) (P >0.05). Exhaled NO levels were similar in patients with AECOPD (155.0 ppb, 129.0-190.0 ppb), stable COPD (154.0 ppb, 133.0-175.0 ppb) and healthy controls (165.0 ppb, 112.0-188.0 ppb) (P >0.05). Exhaled H2S levels correlated positively with exhaled NO in all healthy controls and patients with COPD (r=0.467, P <0.01). No significant correlation was found between the exhaled H2S level and percentage of predicted FEV1 (P >0.05) and proportion of different cell types in induced sputum (P >0.05).

Conclusions There is a correlation between exhaled H2S and exhaled NO. The role of exhaled H2S in airway inflammation in COPD still needs further investigation.

语种: 英语
所属项目编号: 81170012
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000329015600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62352
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Resp Med, Beijing 100191, Peoples R China
2.Beijing Tongren Hosp, Dept Resp Med, Beijing 100730, Peoples R China

Recommended Citation:
Sun Yun,Wang Xin-mao,Chen Ya-hong,et al. Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxide[J]. CHINESE MEDICAL JOURNAL,2013,126(17):3240-3244.
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