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学科主题临床医学
Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxide
Sun Yun1; Wang Xin-mao2; Chen Ya-hong1; Zhu Rui-xia1; Liao Cheng-cheng1
关键词chronic obstructive pulmonary disease nitric oxide hydrogen sulfide
刊名CHINESE MEDICAL JOURNAL
2013-09-05
DOI10.3760/cma.j.issn.0366-6999.20123064
126期:17页:3240-3244
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]OXIDATIVE STRESS ; SODIUM SULFIDE ; ASTHMA ; BREATH ; COPD ; SPUTUM ; RATS ; GAS
英文摘要

Background Exhaled nitric oxide (NO) is a noninvasive biomarker of airway inflammation in pulmonary diseases. Hydrogen sulfide (H2S), as the third member of the gasotransmitter family, is involved in the pathophysiological process in lung diseases. H2S also exists in exhaled breath and can be sampled non-invasively. The study investigated the level of exhaled H2S in patients with chronic obstructive pulmonary disease (COPD) and its correlation with exhaled NO.

Methods Levels of exhaled NO and H2S, lung function, and cell differential counts in induced sputum were studied in 19 patients with acute exacerbation of COPD (AECOPD), 19 patients with stable COPD and seven healthy smoke controls.

Results Exhaled H2S levels were similar in patients with AECOPD (10.0 parts per billion (ppb), 8.0-13.0 ppb), stable COPD (10.0 ppb, 9.0-12.0 ppb), and healthy controls (9.0 ppb, 8.0-16.0 ppb) (P >0.05). Exhaled NO levels were similar in patients with AECOPD (155.0 ppb, 129.0-190.0 ppb), stable COPD (154.0 ppb, 133.0-175.0 ppb) and healthy controls (165.0 ppb, 112.0-188.0 ppb) (P >0.05). Exhaled H2S levels correlated positively with exhaled NO in all healthy controls and patients with COPD (r=0.467, P <0.01). No significant correlation was found between the exhaled H2S level and percentage of predicted FEV1 (P >0.05) and proportion of different cell types in induced sputum (P >0.05).

Conclusions There is a correlation between exhaled H2S and exhaled NO. The role of exhaled H2S in airway inflammation in COPD still needs further investigation.

语种英语
WOS记录号WOS:000329015600008
项目编号81170012
资助机构National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62352
专题北京大学第三临床医学院_呼吸科
作者单位1.Peking Univ Third Hosp, Dept Resp Med, Beijing 100191, Peoples R China
2.Beijing Tongren Hosp, Dept Resp Med, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Sun Yun,Wang Xin-mao,Chen Ya-hong,et al. Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxide[J]. CHINESE MEDICAL JOURNAL,2013,126(17):3240-3244.
APA Sun Yun,Wang Xin-mao,Chen Ya-hong,Zhu Rui-xia,&Liao Cheng-cheng.(2013).Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxide.CHINESE MEDICAL JOURNAL,126(17),3240-3244.
MLA Sun Yun,et al."Exhaled hydrogen sulfide in patients with chronic obstructive pulmonary disease and its correlation with exhaled nitric oxide".CHINESE MEDICAL JOURNAL 126.17(2013):3240-3244.
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