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学科主题: 公共卫生
题名:
Exhaled carbon monoxide and its associations with smoking, indoor household air pollution and chronic respiratory diseases among 512 000 Chinese adults
作者: Zhang, Qiuli1,2; Li, Liming3,4; Smith, Margaret1,2; Guo, Yu4; Whitlock, Gary1,2; Bian, Zheng4; Kurmi, Om1,2; Collins, Rory1,2; Chen, Junshi5; Lv, Silu6; Pang, Zhigang7; Chen, Chunxing8; Chen, Naying9; Xiong, Youping10; Peto, Richard1,2; Chen, Zhengming1,2; China Kadoorie Biobank Study
关键词: Exhaled carbon monoxide ; smoking ; household air pollution ; epidemiology ; China
刊名: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
发表日期: 2013-10-01
DOI: 10.1093/ije/dyt158
卷: 42, 期:5, 页:1464-1475
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: CARBOXYHEMOGLOBIN LEVELS ; TOBACCO SMOKING ; HEALTH IMPACTS ; PREVALENCE ; EXPOSURE ; POPULATION ; NONSMOKERS ; SMOKERS ; BREATH ; THIOCYANATE
英文摘要:

Background Exhaled carbon monoxide (COex) level is positively associated with tobacco smoking and exposure to smoke from biomass/coal burning. Relatively little is known about its determinants in China despite the population having a high prevalence of smoking and use of biomass/coal.

Methods The China Kadoorie Biobank includes 512 000 participants aged 30-79 years recruited from 10 diverse regions. We used linear regression and logistic regression methods to assess the associations of COex level with smoking, exposures to indoor household air pollution and prevalent chronic respiratory conditions among never smokers, both overall and by seasons, regions and smoking status.

Results The overall COex level (ppm) was much higher in current smokers than in never smokers (men: 11.5 vs 3.7; women: 9.3 vs 3.2). Among current smokers, it was higher among those who smoked more and inhaled more deeply. Among never smokers, mean COex was positively associated with levels of exposures to passive smoking and to biomass/coal burning, especially in rural areas and during winter. The odds ratios (OR) and 95% confidence interval (CI) of air flow obstruction (FEV1/FVC ratio < 0.7) for never smokers with COex at 7-14 and epsilon 14 ppm, compared with those having COex < 7, were 1.38 (1.31-1.45) and 1.65 (1.52-1.80), respectively (P-trend < 0.001). Prevalence of other self-reported chronic respiratory conditions was also higher among people with elevated COex (P < 0.05).

Conclusion In adult Chinese, COex can be used as a biomarker for assessing current smoking and overall exposure to indoor household air pollution in combination with questionnaires.

语种: 英语
所属项目编号: 088158/Z/09/Z
项目资助者: Kadoorie Charitable Foundation in Hong Kong ; Wellcome Trust in the UK ; National Key Technology Research and Development Program in the 12th Five-Year Plan, Ministry of Science and Technology, China ; UK Medical Research Council ; British Heart Foundation ; Cancer Research UK
WOS记录号: WOS:000326726000038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62354
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Univ Oxford, Clin Trial Serv Unit, Oxford OX3 7LF, England
2.China Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China
3.Licang Ctr Dis Control & Prevent, Qingdao, Shandong, Peoples R China
4.Meilan Ctr Dis Control & Prevent, Haikou, Hainan, Peoples R China
5.Guangxi Ctr Dis Control & Prevent, Nanning, Guangxi, Peoples R China
6.Liuyang Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China
7.Univ Oxford, Epidemiol Studies Unit CTSU, Oxford OX3 7LF, England
8.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China
9.Chinese Acad Med Sci, Beijing 100730, Peoples R China
10.Heilongjiang Ctr Dis Control & Prevent, Harbin, Heilongjiang, Peoples R China

Recommended Citation:
Zhang, Qiuli,Li, Liming,Smith, Margaret,et al. Exhaled carbon monoxide and its associations with smoking, indoor household air pollution and chronic respiratory diseases among 512 000 Chinese adults[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2013,42(5):1464-1475.
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