IR@PKUHSC  > 北京大学公共卫生学院
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Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012
Zhang, Xiao-Ai1; Lu, Qing-Bin2; Wo, Ying1; Zhao, Jin1; Huang, Dou-Dou1,3; Guo, Chen-Tao1,3; Xu, Hong-Mei4; Liu, En-Mei4; Liu, Wei1; Cao, Wu-Chun1
刊名SCIENTIFIC REPORTS
2015-01-09
DOI10.1038/srep07704
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SAFV GENOTYPE 3 ; PHYLOGENETIC ANALYSES ; VIRUS-INFECTION ; THEILERS VIRUS ; VILYUISK VIRUS ; RT-PCR ; CHILDREN ; JAPAN ; IDENTIFICATION ; SEROEPIDEMIOLOGY
英文摘要

The epidemiology and clinical features of the Saffold cardiovirus (SAFV) remain ambiguous. The present study was designed to systematically and intensively investigate the epidemiological features of SAFV in pediatric patients in China. Three cohorts of pediatric patients were recruited from 2009 to 2012. Cohort 1 comprised patients with acute respiratory tract infections. Cohort 2 comprised patients with diarrhea. Cohort 3 comprised hand, foot, and mouth disease (HFMD) patients. A total of 115 patients (1.6%) among 6052 (17/1647, 12/2013, and 86/2392 in cohorts 1, 2, and 3, respectively) were SAFV-positive. The samples from 82 SAFV-positive patients were successfully sequenced, and four genotypes were identified: 8 SAFV-1, 41 SAFV-2, 29 SAFV-3, and 4 SAFV-6. A significantly higher detection rate was found in the HFMD patients than in other two cohorts (both P<0.001). A higher frequency of severe clinical outcome and nervous system manifestation were also observed in the SAFV-positive HFMD patients. Additionally, 6 (3.5%) cerebrospinal fluid and 7 (2.2%) serum samples from the HFMD-associated encephalitis patients were SAFV-positive. Based on the VP1 sequences, all four genotypes displayed distinct geographical clustering. SAFV infection might be associated with a wide clinical spectrum and contribute to HFMD.

语种英语
WOS记录号WOS:000354222900006
项目编号2013ZX10004202 ; 81222037 ; BWS11C073
资助机构China Mega-Project on Infectious Disease Prevention ; National Natural Science Foundation ; Military Medical and Technology Twelfth Five-Year Science and Research Key Plan
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62355
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China
3.Chongqing Med Univ, Childrens Hosp, Chongqing 400014, Peoples R China
4.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiao-Ai,Lu, Qing-Bin,Wo, Ying,et al. Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012[J]. SCIENTIFIC REPORTS,2015,5.
APA Zhang, Xiao-Ai.,Lu, Qing-Bin.,Wo, Ying.,Zhao, Jin.,Huang, Dou-Dou.,...&Cao, Wu-Chun.(2015).Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012.SCIENTIFIC REPORTS,5.
MLA Zhang, Xiao-Ai,et al."Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012".SCIENTIFIC REPORTS 5(2015).
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