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学科主题: 公共卫生
题名:
Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012
作者: Zhang, Xiao-Ai1; Lu, Qing-Bin2; Wo, Ying1; Zhao, Jin1; Huang, Dou-Dou1,3; Guo, Chen-Tao1,3; Xu, Hong-Mei4; Liu, En-Mei4; Liu, Wei1; Cao, Wu-Chun1
刊名: SCIENTIFIC REPORTS
发表日期: 2015-01-09
DOI: 10.1038/srep07704
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SAFV GENOTYPE 3 ; PHYLOGENETIC ANALYSES ; VIRUS-INFECTION ; THEILERS VIRUS ; VILYUISK VIRUS ; RT-PCR ; CHILDREN ; JAPAN ; IDENTIFICATION ; SEROEPIDEMIOLOGY
英文摘要:

The epidemiology and clinical features of the Saffold cardiovirus (SAFV) remain ambiguous. The present study was designed to systematically and intensively investigate the epidemiological features of SAFV in pediatric patients in China. Three cohorts of pediatric patients were recruited from 2009 to 2012. Cohort 1 comprised patients with acute respiratory tract infections. Cohort 2 comprised patients with diarrhea. Cohort 3 comprised hand, foot, and mouth disease (HFMD) patients. A total of 115 patients (1.6%) among 6052 (17/1647, 12/2013, and 86/2392 in cohorts 1, 2, and 3, respectively) were SAFV-positive. The samples from 82 SAFV-positive patients were successfully sequenced, and four genotypes were identified: 8 SAFV-1, 41 SAFV-2, 29 SAFV-3, and 4 SAFV-6. A significantly higher detection rate was found in the HFMD patients than in other two cohorts (both P<0.001). A higher frequency of severe clinical outcome and nervous system manifestation were also observed in the SAFV-positive HFMD patients. Additionally, 6 (3.5%) cerebrospinal fluid and 7 (2.2%) serum samples from the HFMD-associated encephalitis patients were SAFV-positive. Based on the VP1 sequences, all four genotypes displayed distinct geographical clustering. SAFV infection might be associated with a wide clinical spectrum and contribute to HFMD.

语种: 英语
所属项目编号: 2013ZX10004202 ; 81222037 ; BWS11C073
项目资助者: China Mega-Project on Infectious Disease Prevention ; National Natural Science Foundation ; Military Medical and Technology Twelfth Five-Year Science and Research Key Plan
WOS记录号: WOS:000354222900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62355
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China
3.Chongqing Med Univ, Childrens Hosp, Chongqing 400014, Peoples R China
4.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

Recommended Citation:
Zhang, Xiao-Ai,Lu, Qing-Bin,Wo, Ying,et al. Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012[J]. SCIENTIFIC REPORTS,2015,5.
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